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Science 8 December 1989:
Vol. 246. no. 4935, pp. 1309 - 1312
DOI: 10.1126/science.2479987
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Articles

Science, Vol 246, Issue 4935, 1309-1312
Copyright © 1989 by American Association for the Advancement of Science

articles

Vascular permeability factor, an endothelial cell mitogen related to PDGF

PJ Keck, SD Hauser, G Krivi, K Sanzo, T Warren, J Feder, and DT Connolly

Department of Cell Culture and Biochemistry, Monsanto Company, St. Louis, MO 63167.

Vascular permeability factor (VPF) is a 40-kilodalton disulfide-linked dimeric glycoprotein that is active in increasing blood vessel permeability, endothelial cell growth, and angiogenesis. These properties suggest that the expression of VPF by tumor cells could contribute to the increased neovascularization and vessel permeability that are associated with tumor vasculature. The cDNA sequence of VPF from human U937 cells was shown to code for a 189-amino acid polypeptide that is similar in structure to the B chain of platelet-derived growth factor (PDGF-B) and other PDGF-B-related proteins. The overall identity with PDGF-B is 18%. However, all eight of the cysteines in PDGF-B were found to be conserved in human VPF, an indication that the folding of the two proteins is probably similar. Clusters of basic amino acids in the COOH-terminal halves of human VPF and PDGF-B are also prevalent. Thus, VPF appears to be related to the PDGF/v-sis family of proteins.


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Vascular Endothelial Growth Factor Isoform Expression as a Determinant of Blood Vessel Patterning in Human Melanoma Xenografts.
J. L. Yu, J. W. Rak, G. Klement, and R. S. Kerbel (2002)
Cancer Res. 62, 1838-1846
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Antiangiogenic Effect by SU5416 Is Partly Attributable to Inhibition of Flt-1 Receptor Signaling.
T. Itokawa, H. Nokihara, Y. Nishioka, S. Sone, Y. Iwamoto, Y. Yamada, J. Cherrington, G. McMahon, M. Shibuya, M. Kuwano, et al. (2002)
Mol. Cancer Ther. 1, 295-302
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Exaggerated Hypotensive Effect of Vascular Endothelial Growth Factor in Spontaneously Hypertensive Rats.
R. Yang, A. K. Ogasawara, T. F. Zioncheck, Z. Ren, G.-W. He, G. G. DeGuzman, N. Pelletier, B.-Q. Shen, S. Bunting, and H. Jin (2002)
Hypertension 39, 815-820
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Localization of VEGF Receptor-2 (KDR/Flk-1) and Effects of Blocking It in Oxygen-Induced Retinopathy.
D. S. McLeod, M. Taomoto, J. Cao, Z. Zhu, L. Witte, and G. A. Lutty (2002)
Invest. Ophthalmol. Vis. Sci. 43, 474-482
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Differential Effects of Bactericidal/Permeability-Increasing Protein (BPI) Analogues on Retinal Neovascularization and Retinal Pericyte Growth.
R. K. Rauniyar, K. Suzuma, A. L. King, L. P. Aiello, and G. L. King (2002)
Invest. Ophthalmol. Vis. Sci. 43, 503-509
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