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Science 15 December 1989:
Vol. 246. no. 4936, pp. 1406 - 1412
DOI: 10.1126/science.2574499
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Articles

Science, Vol 246, Issue 4936, 1406-1412
Copyright © 1989 by American Association for the Advancement of Science

articles

Tumor suppressor genes: the puzzle and the promise

R Sager

Division of Cancer Genetics, Dana-Farber Cancer Institute, Boston, MA.

Tumor suppressor genes are wild-type alleles of genes that play regulatory roles in cell proliferation, differentiation, and other cellular and systemic processes. It is their loss or inactivation that is oncogenic. The first evidence of tumor suppressor genes appeared in the early 1970s, but only within the past few years has a wealth of new information illuminated the central importance of these genes. Two or more different suppressor genes may be inactivated in the same tumors, and the same suppressors may be inactive in different tumor types (for example, lung, breast, and colon). The suppressor genes already identified are involved in cell cycle control, signal transduction, angiogenesis, and development, indicating that they contribute to a broad array of normal and tumor-related functions. It is proposed that tumor suppressor genes provide a vast untapped resource for anticancer therapy.


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