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Science 22 December 1989:
Vol. 246. no. 4937, pp. 1632 - 1634
DOI: 10.1126/science.2480644
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Articles

Science, Vol 246, Issue 4937, 1632-1634
Copyright © 1989 by American Association for the Advancement of Science

articles

RNA editing in plant mitochondria

R Hiesel, B Wissinger, W Schuster, and A Brennicke

Institut fur Genbiologische Forschung, Berlin, Federal Republic of Germany.

Comparative sequence analysis of genomic and complementary DNA clones from several mitochondrial genes in the higher plant Oenothera revealed nucleotide sequence divergences between the genomic and the messenger RNA-derived sequences. These sequence alterations could be most easily explained by specific post-transcriptional nucleotide modifications. Most of the nucleotide exchanges in coding regions lead to altered codons in the mRNA that specify amino acids better conserved in evolution than those encoded by the genomic DNA. Several instances show that the genomic arginine codon CGG is edited in the mRNA to the tryptophan codon TGG in amino acid positions that are highly conserved as tryptophan in the homologous proteins of other species. This editing suggests that the standard genetic code is used in plant mitochondria and resolves the frequent coincidence of CGG codons and tryptophan in different plant species. The apparently frequent and non-species-specific equivalency of CGG and TGG codons in particular suggests that RNA editing is a common feature of all higher plant mitochondria.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Computational Analysis of RNA Editing Sites in Plant Mitochondrial Genomes Reveals Similar Information Content and a Sporadic Distribution of Editing Sites.
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cis Recognition Elements in Plant Mitochondrion RNA Editing.
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Editing of transfer RNAs in Acanthamoeba castellanii mitochondria.
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The Texas Cytoplasm of Maize: Cytoplasmic Male Sterility and Disease Susceptibility.
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