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Science 29 June 1990:
Vol. 248. no. 4963, pp. 1619 - 1624
DOI: 10.1126/science.2114039
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Articles

Science, Vol 248, Issue 4963, 1619-1624
Copyright © 1990 by American Association for the Advancement of Science

articles

Comparison of two forms of long-term potentiation in single hippocampal neurons

RA Zalutsky and RA Nicoll

Department of Pharmacology and Physiology, University of California, San Francisco, CA 94114-0450.

In invertebrate nervous systems, some long-lasting increases in synaptic efficacy result from changes in the presynaptic cell. In the vertebrate nervous system, the best understood long-lasting change in synaptic strength is long-term potentiation (LTP) in the CA1 region of the hippocampus. Here the process is initiated postsynaptically, but the site of the persistent change is unresolved. Single CA3 hippocampal pyramidal cells receive excitatory inputs from associational-commissural fibers and from the mossy fibers of dentate granule cells and both pathways exhibit LTP. Although the induction of associational-commissural LTP requires in the postsynaptic cell N-methyl-D-aspartate (NMDA) receptor activation, membrane depolarization, and a rise in calcium, mossy fiber LTP does not. Paired-pulse facilitation, which is an index of increased transmitter release, is unaltered during associational-commissural LTP but is reduced during mossy fiber LTP. Thus, both the induction and the persistent change may be presynaptic in mossy fiber LTP but not in associational-commissural LTP.


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Differing Mechanisms of Expression for Short- and Long-Term Potentiation.
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Long-term potentiation involves increases in the probability of neurotransmitter release.
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