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Science 29 June 1990:
Vol. 248. no. 4963, pp. 1646 - 1650
DOI: 10.1126/science.2194289
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Articles

Science, Vol 248, Issue 4963, 1646-1650
Copyright © 1990 by American Association for the Advancement of Science

articles

Cloning of a transcriptionally active human TATA binding factor

CC Kao, PM Lieberman, MC Schmidt, Q Zhou, R Pei, and AJ Berk

Department of Microbiology, Molecular Biology Institute, University of California, Los Angeles 90024-1570.

Transcription factor IID (TFIID) binds to the TATA box promoter element and regulates the expression of most eukaryotic genes transcribed by RNA polymerase II. Complementary DNA (cDNA) encoding a human TFIID protein has been cloned. The human TFIID polypeptide has 339 amino acids and a molecular size of 37,745 daltons. The carboxyl-terminal 181 amino acids of the human TFIID protein shares 80% identity with the TFIID protein from Saccharomyces cerevisiae. The amino terminus contains an unusual repeat of 38 consecutive glutamine residues and an X-Thr-Pro repeat. Expression of DNA in reticulocyte lysates or in Escherichia coli yielded a protein that was competent for both DNA binding and transcription activation.


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Q Zhou, T G Boyer, and A J Berk (1993)
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Holo-TFIID supports transcriptional stimulation by diverse activators and from a TATA-less promoter..
Q Zhou, P M Lieberman, T G Boyer, and A J Berk (1992)
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Cloning of the 62-kilodalton component of basic transcription factor BTF2.
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A protein-binding site in the c-myc promoter functions as a terminator of RNA polymerase II transcription..
S Roberts, T Purton, and D L Bentley (1992)
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Transcription factor IID mutants defective for interaction with transcription factor IIA.
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Yeast and human TFIIDs are interchangeable for the response to acidic transcriptional activators in vitro..
R J Kelleher, P M Flanagan, D I Chasman, A S Ponticelli, K Struhl, and R D Kornberg (1992)
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TFIID can be rate limiting in vivo for TATA-containing, but not TATA-lacking, RNA polymerase II promoters..
J Colgan and J L Manley (1992)
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Coactivators for a proline-rich activator purified from the multisubunit human TFIID complex..
N Tanese, B F Pugh, and R Tjian (1991)
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The Zta trans-activator protein stabilizes TFIID association with promoter DNA by direct protein-protein interaction..
P M Lieberman and A J Berk (1991)
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Transcription from a TATA-less promoter requires a multisubunit TFIID complex..
B F Pugh and R Tjian (1991)
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The mammalian TFIID protein is present in two functionally distinct complexes..
H T Timmers and P A Sharp (1991)
Genes & Dev. 5, 1946-1956
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The cloned RNA polymerase II transcription factor IID selects RNA polymerase III to transcribe the human U6 gene in vitro..
S M Lobo, J Lister, M L Sullivan, and N Hernandez (1991)
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The Binding Interaction of HMG-1 with the TATA-binding Protein/TATA Complex.
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