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Science 20 July 1990:
Vol. 249. no. 4966, pp. 283 - 287
DOI: 10.1126/science.1695760
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Articles

Science, Vol 249, Issue 4966, 283-287
Copyright © 1990 by American Association for the Advancement of Science

articles

Characterization of naturally occurring minor histocompatibility peptides including H-4 and H-Y

O Rotzschke, K Falk, HJ Wallny, S Faath, and HG Rammensee

Max-Planck-Institut fur Biologie, Abteilung Immungenetik, Tubingen, Federal Republic of Germany.

Minor histocompatibility (H) antigens can be peptides derived from cellular proteins that are presented on the cell surface by major histocompatibility complex (MHC) class I molecules. This is similar to viral antigens, because in both cases cytotoxic T lymphocytes (CTLs) recognize artificially produced peptides loaded on target cells. Naturally processed minor H peptides were found to be similar to those artificial CTL-epitopes, as far as size and hydrophobicity is concerned. The peptides studied were isolated from a transfectant that expressed a model CTL-defined antigen, beta-galactosidase, from male cells that express H-Y, which has been known operationally since 1955, and from cells that express H-4, known since 1961.


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