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Science 27 July 1990:
Vol. 249. no. 4967, pp. 414 - 417
DOI: 10.1126/science.1696029
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Articles

Science, Vol 249, Issue 4967, 414-417
Copyright © 1990 by American Association for the Advancement of Science

articles

Prevention of activated neutrophil adhesion to endothelium by soluble adhesion protein GMP140

Gamble JR, MP Skinner, MC Berndt, and MA Vadas

Division of Human Immunology, Institute of Medical and Veterinary Science, Adelaide, South Australia.

Neutrophils and monocytes, but not lymphocytes, adhered strongly to plastic surfaces coated with GMP140, a protein of endothelial cells and platelets. This adhesion of neutrophils was mediated by GMP140 and not by the CD18 integrin complex. By contrast, GMP140 in solution inhibited the CD18-dependent adhesion of tumor necrosis factor-alpha-activated neutrophils to plastic surfaces and resting endothelium, but not of resting neutrophils to tumor necrosis factor-alpha-activated endothelium. Thus, the binding of a soluble form of an adhesion protein selectively inhibited another set of adhesive events. Soluble GMP140 may be important in maintaining the nonadhesiveness of neutrophils in the circulation and may serve to limit inflammatory reactions.


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