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Science 17 August 1990:
Vol. 249. no. 4970, pp. 790 - 793
DOI: 10.1126/science.2167514
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Articles

Science, Vol 249, Issue 4970, 790-793
Copyright © 1990 by American Association for the Advancement of Science

articles

Hypertriglyceridemia as a result of human apo CIII gene expression in transgenic mice

Y Ito, N Azrolan, A O'Connell, A Walsh, and JL Breslow

Rockefeller University, New York, NY 10021.

Primary and secondary hypertriglyceridemia is common in the general population, but the biochemical basis for this disease is largely unknown. With the use of transgenic technology, two lines of mice were created that express the human apolipoprotein CIII gene. One of these mouse lines with 100 copies of the gene was found to express large amounts of the protein and to be severely hypertriglyceridemic. The other mouse line with one to two copies of the gene expressed low amounts of the protein, but nevertheless manifested mild hypertriglyceridemia. Thus, overexpression of apolipoprotein CIII can be a primary cause of hypertriglyceridemia in vivo and may provide one possible etiology for this common disorder in humans.


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Arterioscler. Thromb. Vasc. Biol. 18, 1780-1789
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Overexpression and Accumulation of Apolipoprotein E as a Cause of Hypertriglyceridemia.
Y. Huang, X. Q. Liu, S. C. Rall Jr., J. M. Taylor, A. von Eckardstein, G. Assmann, and R. W. Mahley (1998)
J. Biol. Chem. 273, 26388-26393
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Evidence Against Linkage of Familial Combined Hyperlipidemia to the Apolipoprotein AI-CIII-AIV Gene Complex.
E. M. Wijsman, J. D. Brunzell, G. P. Jarvik, M. A. Austin, A. G. Motulsky, and S. S. Deeb (1998)
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Altered Myocardial Vasodilatation in Patients With Hypertriglyceridemia in Anatomically Normal Coronary Arteries.
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Inhibitory Effects of Specific Apolipoprotein C-III Isoforms on the Binding of Triglyceride-rich Lipoproteins to the Lipolysis-stimulated Receptor.
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Common Genomic Variation in the APOC3 Promoter Associated With Variation in Plasma Lipoproteins.
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Circulation 94, 2046-2051
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