Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 17 August 1990:
Vol. 249. no. 4970, pp. 796 - 798
DOI: 10.1126/science.1697103
Prev | Table of Contents | Next

Articles

Science, Vol 249, Issue 4970, 796-798
Copyright © 1990 by American Association for the Advancement of Science

articles

Expression of gene rrg is associated with reversion of NIH 3T3 transformed by LTR-c-H-ras

S Contente, K Kenyon, D Rimoldi, and RM Friedman

Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4799.

A partial complementary DNA was isolated for a gene (rrg) that is normally expressed in mouse NIH 3T3 cells, but is down-regulated after cellular transformation by long terminal repeat (LTR)-activated c-H-ras (LTR-c-H-ras). This gene was reexpressed in a nontumorigenic persistent revertant cell line created by prolonged treatment of the transformed cells with mouse interferon alpha/beta. Persistent revertants stably transfected with rrg complementary DNA antisense expression vectors appeared transformed, had decreased amounts of rrg messenger RNA, and were tumorigenic in nude mice. Stable transfection with sense constructs did not alter the normal morphology, message level, or nontumorigenicity of the persistent revertant cell line.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Tumor Suppressive Protein Gene Associated with Retinoid-Interferon-Induced Mortality (GRIM)-19 Inhibits src-Induced Oncogenic Transformation at Multiple Levels.
S. Kalakonda, S. C. Nallar, P. Gong, D. J. Lindner, S. E. Goldblum, S. P. Reddy, and D. V. Kalvakolanu (2007)
Am. J. Pathol. 171, 1352-1368
   Abstract »    Full Text »    PDF »
Repression of BCL2 by the Tumor Suppressor Activity of the Lysyl Oxidase Propeptide Inhibits Transformed Phenotype of Lung and Pancreatic Cancer Cells.
M. Wu, C. Min, X. Wang, Z. Yu, K. H. Kirsch, P. C. Trackman, and G. E. Sonenshein (2007)
Cancer Res. 67, 6278-6285
   Abstract »    Full Text »    PDF »
Intracellular distribution of the lysyl oxidase propeptide in osteoblastic cells.
Y. Guo, N. Pischon, A. H. Palamakumbura, and P. C. Trackman (2007)
Am J Physiol Cell Physiol 292, C2095-C2102
   Abstract »    Full Text »    PDF »
LOXL1 and LOXL4 Are Epigenetically Silenced and Can Inhibit Ras/Extracellular Signal-Regulated Kinase Signaling Pathway in Human Bladder Cancer.
G. Wu, Z. Guo, X. Chang, M. S. Kim, J. K. Nagpal, J. Liu, J. M. Maki, K. I. Kivirikko, S. P. Ethier, B. Trink, et al. (2007)
Cancer Res. 67, 4123-4129
   Abstract »    Full Text »    PDF »
The Tumor Suppressor Activity of the Lysyl Oxidase Propeptide Reverses the Invasive Phenotype of Her-2/neu-Driven Breast Cancer.
C. Min, K. H. Kirsch, Y. Zhao, S. Jeay, A. H. Palamakumbura, P. C. Trackman, and G. E. Sonenshein (2007)
Cancer Res. 67, 1105-1112
   Abstract »    Full Text »    PDF »
The Lysyl Oxidase LOX Is Absent in Basal and Squamous Cell Carcinomas and Its Knockdown Induces an Invading Phenotype in a Skin Equivalent Model.
C. Bouez, C. Reynaud, E. Noblesse, A. Thepot, C. Gleyzal, J. Kanitakis, E. Perrier, O. Damour, and P. Sommer (2006)
Clin. Cancer Res. 12, 1463-1469
   Abstract »    Full Text »    PDF »
Drosophila Lysyl Oxidases Dmloxl-1 and Dmloxl-2 Are Differentially Expressed and the Active DmLOXL-1 Influences Gene Expression and Development.
J. Molnar, Z. Ujfaludi, S. F. T. Fong, J. A. Bollinger, G. Waro, B. Fogelgren, D. M. Dooley, M. Mink, and K. Csiszar (2005)
J. Biol. Chem. 280, 22977-22985
   Abstract »    Full Text »    PDF »
The Propeptide Domain of Lysyl Oxidase Induces Phenotypic Reversion of Ras-transformed Cells.
A. H. Palamakumbura, S. Jeay, Y. Guo, N. Pischon, P. Sommer, G. E. Sonenshein, and P. C. Trackman (2004)
J. Biol. Chem. 279, 40593-40600
   Abstract »    Full Text »    PDF »
Lysyl Oxidase Is a Tumor Suppressor Gene Inactivated by Methylation and Loss of Heterozygosity in Human Gastric Cancers.
A. Kaneda, K. Wakazono, T. Tsukamoto, N. Watanabe, Y. Yagi, M. Tatematsu, M. Kaminishi, T. Sugimura, and T. Ushijima (2004)
Cancer Res. 64, 6410-6415
   Abstract »    Full Text »    PDF »
Autocrine Growth Factor Regulation of Lysyl Oxidase Expression in Transformed Fibroblasts.
A. H. Palamakumbura, P. Sommer, and P. C. Trackman (2003)
J. Biol. Chem. 278, 30781-30787
   Abstract »    Full Text »    PDF »
Genomic profiles and predictive biological networks in oxidant-induced atherogenesis.
C. D. Johnson, Y. Balagurunathan, K. P. Lu, M. Tadesse, M. H. Falahatpisheh, R. J. Carroll, E. R. Dougherty, C. A. Afshari, and K. S. Ramos (2003)
Physiol Genomics 13, 263-275
   Abstract »    Full Text »    PDF »
Lysyl Oxidase Inhibits Ras-Mediated Transformation by Preventing Activation of NF-{kappa}B.
S. Jeay, S. Pianetti, H. M. Kagan, and G. E. Sonenshein (2003)
Mol. Cell. Biol. 23, 2251-2263
   Abstract »    Full Text »    PDF »
Lysyl Oxidase-related Protein-1 Promotes Tumor Fibrosis and Tumor Progression in Vivo.
G. Akiri, E. Sabo, H. Dafni, Z. Vadasz, Y. Kartvelishvily, N. Gan, O. Kessler, T. Cohen, M. Resnick, M. Neeman, et al. (2003)
Cancer Res. 63, 1657-1666
   Abstract »    Full Text »    PDF »
Identification of Silencing of Nine Genes in Human Gastric Cancers.
A. Kaneda, M. Kaminishi, K. Yanagihara, T. Sugimura, and T. Ushijima (2002)
Cancer Res. 62, 6645-6650
   Abstract »    Full Text »    PDF »
Low Density Lipoproteins Downregulate Lysyl Oxidase in Vascular Endothelial Cells and the Arterial Wall.
C. Rodriguez, B. Raposo, J. Martinez-Gonzalez, L. Casani, and L. Badimon (2002)
Arterioscler. Thromb. Vasc. Biol. 22, 1409-1414
   Abstract »    Full Text »    PDF »
A Molecular Role for Lysyl Oxidase in Breast Cancer Invasion.
D. A. Kirschmann, E. A. Seftor, S. F. T. Fong, D. R. C. Nieva, C. M. Sullivan, E. M. Edwards, P. Sommer, K. Csiszar, and M. J. C. Hendrix (2002)
Cancer Res. 62, 4478-4483
   Abstract »    Full Text »    PDF »
The LOXL2 Gene Encodes a New Lysyl Oxidase-like Protein and Is Expressed at High Levels in Reproductive Tissues.
C. J.-L. Saux, H. Tronecker, L. Bogic, G. D. Bryant-Greenwood, C. D. Boyd, and K. Csiszar (1999)
J. Biol. Chem. 274, 12939-12944
   Abstract »    Full Text »    PDF »
Localization and activity of lysyl oxidase within nuclei of fibrogenic cells.
W. Li, K. Nellaiappan, T. Strassmaier, L. Graham, K. M. Thomas, and H. M. Kagan (1997)
PNAS 94, 12817-12822
   Abstract »    Full Text »    PDF »
Growth-inhibitory Activity and Downregulation of the Class II Tumor-suppressor Gene H-rev107 in Tumor Cell Lines and Experimental Tumors.
C. Sers, U. Emmenegger, K. Husmann, K. Bucher, A.-C. Andres, and R. Schafer (1997)
J. Cell Biol. 136, 935-944
   Abstract »    Full Text »    PDF »
Lysyl Oxidase (ras Recision Gene) Expression in Human Amnion: Ontogeny and Cellular Localization.
M. L. Casey and P. C. MacDonald (1997)
J. Clin. Endocrinol. Metab. 82, 167-172
   Abstract »    Full Text »    PDF »
Metalloproteinase Activity Secreted by Fibrogenic Cells in the Processing of Prolysyl Oxidase.
M. V. Panchenko, W. G. Stetler-Stevenson, O. V. Trubetskoy, S. N. Gacheru, and H. M. Kagan (1996)
J. Biol. Chem. 271, 7113-7119
   Abstract »    Full Text »    PDF »
Quantitative Polymerase Chain Reaction of Lysyl Oxidase mRNA in Malignantly Transformed Human Cell Lines Demonstrates That Their Low Lysyl Oxidase Activity Is Due to Low Quantities of Its mRNA and Low Levels of Transcription of the Respective Gene.
E.-R. Hämäläinen, R. Kemppainen, H. Kuivaniemi, G. Tromp, A. Vaheri, T. Pihlajaniemi, and K. I. Kivirikko (1995)
J. Biol. Chem. 270, 21590-21593
   Abstract »    Full Text »    PDF »
A New Gene with Sequence and Structural Similarity to the Gene Encoding Human Lysyl Oxidase.
Y. Kim and K. Csiszar (1995)
J. Biol. Chem. 270, 7176-7182
   Abstract »    Full Text »    PDF »
Lysyl oxidase and rrg messenger RNA.
K Kenyon, S Contente, P. Trackman, J Tang, H. Kagan, and R. Friedman (1991)
Science 253, 802
   PDF »
Lysyl Oxidase Activates the Transcription Activity of Human Collagene III Promoter. POSSIBLE INVOLVEMENT OF Ku ANTIGEN.
M. Giampuzzi, G. Botti, M. Di Duca, L. Arata, G. Ghiggeri, R. Gusmano, R. Ravazzolo, and A. Di Donato (2000)
J. Biol. Chem. 275, 36341-36349
   Abstract »    Full Text »    PDF »
Down-regulation of Lysyl Oxidase-induced Tumorigenic Transformation in NRK-49F Cells Characterized by Constitutive Activation of Ras Proto-oncogene.
M. Giampuzzi, G. Botti, M. Cilli, R. Gusmano, A. Borel, P. Sommer, and A. Di Donato (2001)
J. Biol. Chem. 276, 29226-29232
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)