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Science 24 August 1990:
Vol. 249. no. 4971, pp. 908 - 912
DOI: 10.1126/science.2392681
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Articles

Science, Vol 249, Issue 4971, 908-912
Copyright © 1990 by American Association for the Advancement of Science

articles

Increased life-span of age-1 mutants in Caenorhabditis elegans and lower Gompertz rate of aging

TE Johnson

Department of Psychology, University of Colorado, Boulder 80309.

A mutation in the age-1 gene of the nematode Caenorhabditis elegans has been shown to result in a 65 percent increase in mean life-span and a 110 percent increase in maximum life-span at 25 degrees. One of the hallmarks of organismic aging and senescent processes is an exponential acceleration of age-specific mortality rate with chronological age. This exponential acceleration is under genetic control: age-1 mutant hermaphrodites show a 50 percent slower rate of acceleration of mortality with chronological age than wild-type strains. Mutant males also show a lengthening of life and a slowing of the rate of acceleration of mortality, although age-1 mutant males still have significantly shorter life-spans than do hermaphrodites of the same genotype. The slower rates of acceleration of mortality are recessive characteristics of the age-1 mutant alleles examined.


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