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Science 24 August 1990:
Vol. 249. no. 4971, pp. 921 - 923
DOI: 10.1126/science.2118273
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Articles

Science, Vol 249, Issue 4971, 921-923
Copyright © 1990 by American Association for the Advancement of Science

articles

The role of B cells for in vivo T cell responses to a Friend virus-induced leukemia

KR Schultz, JP Klarnet, RS Gieni, KT HayGlass, and PD Greenberg

Department of Pediatrics, University of Washington, Seattle 98195.

B cells can function as antigen-presenting cells and accessory cells for T cell responses. This study evaluated the role of B cells in the induction of protective T cell immunity to a Friend murine leukemia virus (F-MuLV)-induced leukemia (FBL). B cell-deficient mice exhibited significantly reduced tumor-specific CD4+ helper and CD8+ cytotoxic T cell responses after priming with FBL or a recombinant vaccinia virus containing F-MuLV antigens. Moreover, these mice had diminished T cell responses to the vaccinia viral antigens. Tumor-primed T cells transferred into B cell-deficient mice effectively eradicated disseminated FBL. Thus, B cells appear necessary for efficient priming but not expression of tumor and viral T cell immunity.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Helper B Cells Promote Cytotoxic T Cell Survival and Proliferation Independently of Antigen Presentation through CD27/CD70 Interactions.
S. Deola, M. C. Panelli, D. Maric, S. Selleri, N. I. Dmitrieva, C. Y. Voss, H. Klein, D. Stroncek, E. Wang, and F. M. Marincola (2008)
J. Immunol. 180, 1362-1372
   Abstract »    Full Text »    PDF »
Activation of thymic T cells by MHC alloantigen requires syngeneic, activated CD4+ T cells and B cells as APC.
T. M Strutt, J. Uzonna, K. K McKinstry, and P. A Bretscher (2006)
Int. Immunol. 18, 719-728
   Abstract »    Full Text »    PDF »
TACI-BLyS signaling via B-cell-dendritic cell cooperation is required for naive CD8+ T-cell priming in vivo.
Y. Diaz-de-Durana, G. T. Mantchev, R. J. Bram, and A. Franco (2006)
Blood 107, 594-601
   Abstract »    Full Text »    PDF »
Essential role for virus-neutralizing antibodies in sterilizing immunity against Friend retrovirus infection.
R. J. Messer, U. Dittmer, K. E. Peterson, and K. J. Hasenkrug (2004)
PNAS 101, 12260-12265
   Abstract »    Full Text »    PDF »
CD4+ T cells eliminate MHC class II-negative cancer cells in vivo by indirect effects of IFN-gamma.
D. Mumberg, P. A. Monach, S. Wanderling, M. Philip, A. Y. Toledano, R. D. Schreiber, and H. Schreiber (1999)
PNAS 96, 8633-8638
   Abstract »    Full Text »    PDF »
Immunity to retroviral infection: The Friend virus model.
K. J. Hasenkrug and B. Chesebro (1997)
PNAS 94, 7811-7816
   Abstract »    Full Text »    PDF »


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