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Science 24 August 1990:
Vol. 249. no. 4971, pp. 926 - 928
DOI: 10.1126/science.2118274
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Articles

Science, Vol 249, Issue 4971, 926-928
Copyright © 1990 by American Association for the Advancement of Science

articles

Cell alignment required in differentiation of Myxococcus xanthus

SK Kim and D Kaiser

Department of Biochemistry, Stanford University School of Medicine, CA 94305.

During fruiting body morphogenesis of Myxococcus xanthus, cell movement is required for transmission of C-factor, a short range intercellular signaling protein necessary for sporulation and developmental gene expression. Nonmotile cells fail to sporulate and to express C-factor-dependent genes, but both defects were rescued by a simple manipulation of cell position that oriented the cells in aligned, parallel groups. A similar pattern of aligned cells normally results from coordinated recruitment of wildtype cells into multicellular aggregates, which later form mature fruiting bodies. It is proposed that directed cell movement establishes critical contacts between adjacent cells, which are required for efficient intercellular C-factor transmission.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
EspA, an Orphan Hybrid Histidine Protein Kinase, Regulates the Timing of Expression of Key Developmental Proteins of Myxococcus xanthus.
P. I. Higgs, S. Jagadeesan, P. Mann, and D. R. Zusman (2008)
J. Bacteriol. 190, 4416-4426
   Abstract »    Full Text »    PDF »
The Myxococcus xanthus Nla4 Protein Is Important for Expression of Stringent Response-Associated Genes, ppGpp Accumulation, and Fruiting Body Development.
F. Ossa, M. E. Diodati, N. B. Caberoy, K. M. Giglio, M. Edmonds, M. Singer, and A. G. Garza (2007)
J. Bacteriol. 189, 8474-8483
   Abstract »    Full Text »    PDF »
Regulation of dev, an Operon That Includes Genes Essential for Myxococcus xanthus Development and CRISPR-Associated Genes and Repeats.
P. Viswanathan, K. Murphy, B. Julien, A. G. Garza, and L. Kroos (2007)
J. Bacteriol. 189, 3738-3750
   Abstract »    Full Text »    PDF »
Combinatorial regulation of genes essential for Myxococcus xanthus development involves a response regulator and a LysR-type regulator.
P. Viswanathan, T. Ueki, S. Inouye, and L. Kroos (2007)
PNAS 104, 7969-7974
   Abstract »    Full Text »    PDF »
Mutations of the Act Promoter in Myxococcus xanthus.
T. M. A. Gronewold and D. Kaiser (2007)
J. Bacteriol. 189, 1836-1844
   Abstract »    Full Text »    PDF »
A three-dimensional model of myxobacterial fruiting-body formation.
O. Sozinova, Y. Jiang, D. Kaiser, and M. Alber (2006)
PNAS 103, 17255-17259
   Abstract »    Full Text »    PDF »
The Selective Value of Bacterial Shape.
K. D. Young (2006)
Microbiol. Mol. Biol. Rev. 70, 660-703
   Abstract »    Full Text »    PDF »
Regulation of the Myxococcus xanthus C-Signal-Dependent {Omega}4400 Promoter by the Essential Developmental Protein FruA..
D. R. Yoder-Himes and L. Kroos (2006)
J. Bacteriol. 188, 5167-5176
   Abstract »    Full Text »    PDF »
Nla18, a Key Regulatory Protein Required for Normal Growth and Development of Myxococcus xanthus..
M. E. Diodati, F. Ossa, N. B. Caberoy, I. R. Jose, W. Hiraiwa, M. M. Igo, M. Singer, and A. G. Garza (2006)
J. Bacteriol. 188, 1733-1743
   Abstract »    Full Text »    PDF »
A three-dimensional model of myxobacterial aggregation by contact-mediated interactions.
O. Sozinova, Y. Jiang, D. Kaiser, and M. Alber (2005)
PNAS 102, 11308-11312
   Abstract »    Full Text »    PDF »
A biochemical oscillator explains several aspects of Myxococcus xanthus behavior during development.
O. A. Igoshin, A. Goldbeter, D. Kaiser, and G. Oster (2004)
PNAS 101, 15760-15765
   Abstract »    Full Text »    PDF »
Mutational Analysis of the fruA Promoter Region Demonstrates that C-Box and 5-Base-Pair Elements Are Important for Expression of an Essential Developmental Gene of Myxococcus xanthus.
D. Srinivasan and L. Kroos (2004)
J. Bacteriol. 186, 5961-5967
   Abstract »    Full Text »    PDF »
Waves and aggregation patterns in myxobacteria.
O. A. Igoshin, R. Welch, D. Kaiser, and G. Oster (2004)
PNAS 101, 4256-4261
   Abstract »    Full Text »    PDF »
Mutational Analysis of the Myxococcus xanthus {Omega}4400 Promoter Region Provides Insight into Developmental Gene Regulation by C Signaling.
D. R. Yoder and L. Kroos (2004)
J. Bacteriol. 186, 661-671
   Abstract »    Full Text »    PDF »
Global Mutational Analysis of NtrC-Like Activators in Myxococcus xanthus: Identifying Activator Mutants Defective for Motility and Fruiting Body Development.
N. B. Caberoy, R. D. Welch, J. S. Jakobsen, S. C. Slater, and A. G. Garza (2003)
J. Bacteriol. 185, 6083-6094
   Abstract »    Full Text »    PDF »
TodK, a Putative Histidine Protein Kinase, Regulates Timing of Fruiting Body Morphogenesis in Myxococcus xanthus.
A. A. Rasmussen and L. Sogaard-Andersen (2003)
J. Bacteriol. 185, 5452-5464
   Abstract »    Full Text »    PDF »
cis Elements Necessary for Developmental Expression of a Myxococcus xanthus Gene That Depends on C Signaling.
P. Viswanathan and L. Kroos (2003)
J. Bacteriol. 185, 1405-1414
   Abstract »    Full Text »    PDF »
Autolysis and Autoaggregation in Pseudomonas aeruginosa Colony Morphology Mutants.
D. A. D'Argenio, M. W. Calfee, P. B. Rainey, and E. C. Pesci (2002)
J. Bacteriol. 184, 6481-6489
   Abstract »    Full Text »    PDF »
act Operon Control of Developmental Gene Expression in Myxococcus xanthus.
T. M. A. Gronewold and D. Kaiser (2002)
J. Bacteriol. 184, 1172-1179
   Abstract »    Full Text »    PDF »
Cell behavior in traveling wave patterns of myxobacteria.
R. Welch and D. Kaiser (2001)
PNAS 98, 14907-14912
   Abstract »    Full Text »    PDF »
Spatial control of cell differentiation in Myxococcus xanthus.
B. Julien, A. D. Kaiser, and A. Garza (2000)
PNAS 97, 9098-9103
   Abstract »    Full Text »    PDF »
A sigma 54 Activator Protein Necessary for Spore Differentiation within the Fruiting Body of Myxococcus xanthus.
L. Gorski, T. Gronewold, and D. Kaiser (2000)
J. Bacteriol. 182, 2438-2444
   Abstract »    Full Text »
The stringent response in Myxococcus xanthus is regulated by SocE and the CsgA C-signaling protein.
E. W. Crawford Jr. and L. J. Shimkets (2000)
Genes & Dev. 14, 483-492
   Abstract »    Full Text »
Identification of the Omega 4499 Regulatory Region Controlling Developmental Expression of a Myxococcus xanthus Cytochrome P-450 System.
M. Fisseha, D. Biran, and L. Kroos (1999)
J. Bacteriol. 181, 5467-5475
   Abstract »    Full Text »
The cell surface-associated intercellular C-signal induces behavioral changes in individual Myxococcus xanthus cells during fruiting body morphogenesis.
L. Jelsbak and L. Sogaard-Andersen (1999)
PNAS 96, 5031-5036
   Abstract »    Full Text »    PDF »
Alignment enhances the cell-to-cell transfer of pilus phenotype.
D. Wall and D. Kaiser (1998)
PNAS 95, 3054-3058
   Abstract »    Full Text »    PDF »
Propagation of traveling waves in excitable media..
B M Sager (1996)
Genes & Dev. 10, 2237-2250
   PDF »
Intercellular C-signaling in Myxococcus xanthus involves a branched signal transduction pathway..
L Sogaard-Andersen, F J Slack, H Kimsey, and D Kaiser (1996)
Genes & Dev. 10, 740-754
   Abstract »    PDF »
A tactile sensory system of Myxococcus xanthus involves an extracellular NAD(P)(+)-containing protein..
B U Lee, K Lee, J Mendez, and L J Shimkets (1995)
Genes & Dev. 9, 2964-2973
   Abstract »    PDF »
Intercellular C-signaling and the traveling waves of Myxococcus..
B Sager and D Kaiser (1994)
Genes & Dev. 8, 2793-2804
   Abstract »    PDF »
Spatial restriction of cellular differentiation..
B Sager and D Kaiser (1993)
Genes & Dev. 7, 1645-1653
   Abstract »    PDF »
Pattern formation by a cell surface-associated morphogen in Myxococcus xanthus.
L. Jelsbak and L. Sogaard-Andersen (2002)
PNAS 99, 2032-2037
   Abstract »    Full Text »    PDF »


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