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Science 7 September 1990:
Vol. 249. no. 4973, pp. 1129 - 1133
DOI: 10.1126/science.2204114
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Articles
Science, Vol 249, Issue 4973, 1129-1133
Copyright © 1990 by American Association for the Advancement of Science
Replicative senescence: the human fibroblast comes of age
S Goldstein
Department of Medicine, University of Arkansas for Medical Sciences, Little Rock.
Human diploid fibroblasts undergo replicative senescence predominantly because of arrest at the G1/S boundary of the cell cycle. Senescent arrest resembles a process of terminal differentiation that appears to involve repression of proliferation-promoting genes with reciprocal new expression of antiproliferative genes, although post-transcriptional factors may also be involved. Identification of participating genes and clarification of their mechanisms of action will help to elucidate the universal cellular decline of biological aging and an important obverse manifestation, the rare escape of cells from senescence leading to immortalization and oncogenesis.
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