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Science 7 September 1990:
Vol. 249. no. 4973, pp. 1157 - 1161
DOI: 10.1126/science.2118682
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Articles

Science, Vol 249, Issue 4973, 1157-1161
Copyright © 1990 by American Association for the Advancement of Science

articles

Redox regulation of fos and jun DNA-binding activity in vitro

C Abate, L Patel, FJ Rauscher 3rd, and T Curran

Department of Molecular Oncology and Virology, Roche Institute of Molecular Biology, Nutley, NJ 07110.

The proto-oncogenes c-fos and c-jun function cooperatively as inducible transcription factors in signal transduction processes. Their protein products, Fos and Jun, form a heterodimeric complex that interacts with the DNA regulatory element known as the activator protein-1 (AP-1) binding site. Dimerization occurs via interaction between leucine zipper domains and serves to bring into proper juxtaposition a region in each protein that is rich in basic amino acids and that forms a DNA-binding domain. DNA binding of the Fos-Jun heterodimer was modulated by reduction-oxidation (redox) of a single conserved cysteine residue in the DNA-binding domains of the two proteins. Furthermore, a nuclear protein was identified that reduced Fos and Jun and stimulated DNA-binding activity in vitro. These results suggest that transcriptional activity mediated by AP-1 binding factors may be regulated by a redox mechanism.


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G. Tell, A. Pines, I. Paron, A. D'Elia, A. Bisca, M. R. Kelley, G. Manzini, and G. Damante (2002)
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In Utero Ethanol Suppresses Cerebellar Activator Protein-1 and Nuclear Factor-kappa B Transcriptional Activation in a Rat Fetal Alcohol Syndrome Model.
G. K. Acquaah-Mensah, J. P. Kehrer, and S. W. Leslie (2002)
J. Pharmacol. Exp. Ther. 301, 277-283
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The Roles of Thioredoxin in Protection against Oxidative Stress-induced Apoptosis in SH-SY5Y Cells.
T. Andoh, P. B. Chock, and C. C. Chiueh (2002)
J. Biol. Chem. 277, 9655-9660
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Mutation in the Glucose-6-phosphate Dehydrogenase Gene Leads to Inactivation of Ku DNA End Binding during Oxidative Stress.
I. S. Ayene, T. D. Stamato, S. K. Mauldin, J. E. Biaglow, S. W. Tuttle, S. F. Jenkins, and C. J. Koch (2002)
J. Biol. Chem. 277, 9929-9935
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