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Science 14 September 1990:
Vol. 249. no. 4974, pp. 1266 - 1272
DOI: 10.1126/science.2119054
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Articles

Science, Vol 249, Issue 4974, 1266-1272
Copyright © 1990 by American Association for the Advancement of Science

articles

Transcription factor interactions: selectors of positive or negative regulation from a single DNA element

MI Diamond, JN Miner, SK Yoshinaga, and KR Yamamoto

Department of Biochemistry and Biophysics, University of California, San Francisco 94143-0448.

The mechanism by which a single factor evokes opposite regulatory effects from a specific DNA sequence is not well understood. In this study, a 25-base pair element that resides upstream of the mouse proliferin gene was examined; it conferred on linked promoters either positive or negative glucocorticoid regulation, depending upon physiological context. This sequence, denoted a "composite" glucocorticoid response element (GRE), was bound selectively in vitro both by the glucocorticoid receptor and by c-Jun and c-Fos, components of the phorbol ester-activated AP-1 transcription factor. Indeed, c-Jun and c-Fos served as selectors of hormone responsiveness: the composite GRE was inactive in the absence of c-Jun, whereas it conferred a positive glucocorticoid effect in the presence of c-Jun, and a negative glucocorticoid effect in the presence of c-Jun and relatively high levels of c-Fos. The receptor also interacted selectively with c-Jun in vitro. A general model for composite GRE action is proposed that invokes both DNA binding and protein-protein interactions by receptor and nonreceptor factors.


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Mol. Endocrinol. 13, 1183-1196
   Abstract »    Full Text »
Receptor Interacting Protein RIP140 Inhibits Both Positive and Negative Gene Regulation by Glucocorticoids.
N. Subramaniam, E. Treuter, and S. Okret (1999)
J. Biol. Chem. 274, 18121-18127
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A Two-Hit Mechanism for Vitamin D3-Mediated Transcriptional Repression of the Granulocyte-Macrophage Colony-Stimulating Factor Gene: Vitamin D Receptor Competes for DNA Binding with NFAT1 and Stabilizes c-Jun.
T. L. Towers, T. P. Staeva, and L. P. Freedman (1999)
Mol. Cell. Biol. 19, 4191-4199
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The Hepatitis B pX Protein Promotes Dimerization and DNA Binding of Cellular Basic Region/Leucine Zipper Proteins by Targeting the Conserved Basic Region.
G. Perini, E. Oetjen, and M. R. Green (1999)
J. Biol. Chem. 274, 13970-13977
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Cyclic Adenosine-3',5'-Monophosphate-Mediated Activation of a Glutamine Synthetase Composite Glucocorticoid Response Element.
J. Richardson, C. Vinson, and J. Bodwell (1999)
Mol. Endocrinol. 13, 546-554
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Turning a Negative into a Positive: Vitamin D Receptor Interactions with the Avian Parathyroid Hormone Response Element.
N. J. Koszewski, S. Ashok, and J. Russell (1999)
Mol. Endocrinol. 13, 455-465
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An Additional Region of Coactivator GRIP1 Required for Interaction with the Hormone-binding Domains of a Subset of Nuclear Receptors.
H. Hong, B. D. Darimont, H. Ma, L. Yang, K. R. Yamamoto, and M. R. Stallcup (1999)
J. Biol. Chem. 274, 3496-3502
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Ligand-Activated Retinoic Acid Receptor Inhibits AP-1 Transactivation by Disrupting c-Jun/c-Fos Dimerization.
X.-F. Zhou, X.-Q. Shen, and L. Shemshedini (1999)
Mol. Endocrinol. 13, 276-285
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