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Science 14 September 1990:
Vol. 249. no. 4974, pp. 1293 - 1295
DOI: 10.1126/science.2119056
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Articles

Science, Vol 249, Issue 4974, 1293-1295
Copyright © 1990 by American Association for the Advancement of Science

articles

Induction of donor-specific unresponsiveness by intrathymic islet transplantation

AM Posselt, CF Barker, JE Tomaszewski, JF Markmann, MA Choti, and A Naji

Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia 19104.

The application of isolated pancreatic islet transplantation for treatment of diabetes mellitus has been hampered by the vulnerability of islet allografts to immunologic rejection. Rat islet allografts that were transplanted into the thymus of recipients treated with a single injection of anti-lymphocyte serum survived indefinitely. A state of donor-specific unresponsiveness was achieved that permitted survival of a second donor strain islet allograft transplanted to an extrathymic site. Maturation of T cell precursors in a thymic microenvironment that is harboring foreign alloantigen may induce the selective unresponsiveness. This model provides an approach for pancreatic islet transplantation and a potential strategy for specific modification of the peripheral immune repertoire.


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