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Science 14 September 1990:
Vol. 249. no. 4974, pp. 1295 - 1297
DOI: 10.1126/science.1697984
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Articles

Science, Vol 249, Issue 4974, 1295-1297
Copyright © 1990 by American Association for the Advancement of Science

articles

LFA-3, CD44, and CD45: physiologic triggers of human monocyte TNF and IL-1 release

DS Webb, Y Shimizu, GA Van Seventer, S Shaw, and TL Gerrard

Food and Drug Administration, Division of Cytokine Biology, Bethesda, MD 20892.

The monocyte-derived cytokines, tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta), are central regulators of the immune response, but the physiologic stimuli for their release remain largely undefined. Engagement of three monocyte glycoproteins, LFA-3, CD44, and CD45, by specific monoclonal antibodies immobilized on plastic induced TNF-alpha and IL-1 beta release. In addition, TNF-alpha was released when monocyte LFA-3 bound immobilized, purified CD2, which is its physiologic receptor. Thus, a receptor-ligand interaction that mediates cell-cell adhesion can transmit the necessary signals for the release of monokines.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Tumor Necrosis Factor-{alpha} Induces Functionally Active Hyaluronan-adhesive CD44 by Activating Sialidase through p38 Mitogen-activated Protein Kinase in Lipopolysaccharide-stimulated Human Monocytic Cells.
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CD44-stimulated human B cells express transcripts specifically involved in immunomodulation and inflammation as analyzed by DNA microarrays.
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Cutting Edge: An Inducible Sialidase Regulates the Hyaluronic Acid Binding Ability of CD44-Bearing Human Monocytes.
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J. Immunol. 162, 5058-5061
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K. Fujii, Y. Tanaka, S. Hubscher, K. Saito, T. Ota, and S. Eto (1999)
J. Immunol. 162, 2391-2398
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Regulation of CD44 Gene Expression by the Proinflammatory Cytokine Interleukin-1beta in Vascular Smooth Muscle Cells.
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.
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Epitope Specificity of CD44 for Monoclonal Antibody-Dependent Facilitation of Marrow Engraftment in a Canine Model.
B. M. Sandmaier, R. Storb, K. L. Bennett, F. R. Appelbaum, and E. B. Santos (1998)
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Overlapping but nonidentical binding sites on CD2 for CD58 and a second ligand CD59.
W. Hahn, E Menu, A. Bothwell, P. Sims, and B. Bierer (1992)
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Science. ISSN 0036-8075 (print), 1095-9203 (online)