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Science 28 September 1990:
Vol. 249. no. 4976, pp. 1533 - 1544
DOI: 10.1126/science.1699273
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Articles

Science, Vol 249, Issue 4976, 1533-1544
Copyright © 1990 by American Association for the Advancement of Science

articles

Molecular targets for AIDS therapy

H Mitsuya, R Yarchoan, and S Broder

National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.

The development of antiretroviral therapy against acquired immunodeficiency syndrome (AIDS) has been an intense research effort since the discovery of the causative agent, human immunodeficiency virus (HIV). A large array of drugs and biologic substances can inhibit HIV replication in vitro. Nucleoside analogs--particularly those belonging to the dideoxynucleoside family--can inhibit reverse transcriptase after anabolic phosphorylation. 3'-Azido-2',3'-dideoxythymidine (AZT) was the first such drug tested in individuals with AIDS, and considerable knowledge of structure-activity relations has emerged for this class of drugs. However, virtually every step in the replication of HIV could serve as a target for a new therapeutic intervention. In the future, non-nucleoside-type drugs will likely become more important in the experimental therapy of AIDS, and antiretroviral therapy will exert major effects against the morbidity and mortality caused by HIV.


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