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Science 28 September 1990:
Vol. 249. no. 4976, pp. 1577 - 1580
DOI: 10.1126/science.2218500
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Articles

Science, Vol 249, Issue 4976, 1577-1580
Copyright © 1990 by American Association for the Advancement of Science

articles

Molecular analysis of acute promyelocytic leukemia breakpoint cluster region on chromosome 17

J Borrow, AD Goddard, D Sheer, and E Solomon

Solomon, Somatic Cell Genetics Laboratory, Imperial Cancer Research Fund, London, United Kingdom.

Acute promyelocytic leukemia (APL; FAB M3) is characterized by a predominance of malignant promyelocytes that carry a reciprocal translocation between the long arms of chromosomes 15 and 17, t(15;17) (q22;q11.2-q12). This translocation has become diagnostic for APL, as it is present in almost 100 percent of cases. A Not I linking clone was used to detect this translocation initially on pulsed-field gel electrophoresis and subsequently with conventional Southern (DNA) analysis. The breakpoints in ten APL cases examined were shown to cluster in a 12-kb region of chromosome 17, containing two CpG-rich islands. The region is the first intron of the retinoic acid receptor alpha gene (RARA).


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Acute Promyelocytic Leukemia.
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N. Engl. J. Med. 329, 177-189
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A mutated retinoic acid receptor-alpha exhibiting dominant-negative activity alters the lineage development of a multipotent hematopoietic cell line..
S Tsai, S Bartelmez, R Heyman, K Damm, R Evans, and S J Collins (1992)
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Characterization of a zinc finger gene disrupted by the t(15;17) in acute promyelocytic leukemia.
A. Goddard, J Borrow, P. Freemont, and E Solomon (1991)
Science 254, 1371-1374
   Abstract »    PDF »
Chromosome aberrations and cancer.
E Solomon, J Borrow, and A. Goddard (1991)
Science 254, 1153-1160
   Abstract »    PDF »
RET Finger Protein Is a Transcriptional Repressor and Interacts with Enhancer of Polycomb That Has Dual Transcriptional Functions.
Y. Shimono, H. Murakami, Y. Hasegawa, and M. Takahashi (2000)
J. Biol. Chem. 275, 39411-39419
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