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Science 9 August 1991:
Vol. 253. no. 5020, pp. 669 - 673
DOI: 10.1126/science.1871601
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Articles

Science, Vol 253, Issue 5020, 669-673
Copyright © 1991 by American Association for the Advancement of Science

articles

Genes for epilepsy mapped in the mouse

ML Rise, WN Frankel, JM Coffin, and TN Seyfried

Department of Biology, Boston College, Chestnut Hill 02167.

The neurological mutant mouse strain E1 is a model for complex partial seizures in humans. The inheritance of epileptic seizures with seven conventional chromosomal markers and over 60 endogenous proviral markers was studied by means of back-crosses of E1 with two seizure-resistant strains, DBA/2J and ABP/LeJ. The major gene responsible for this epileptic phenotype (El-1) was localized to a region distal with respect to the centromere on chromosome 9. At least one other gene, El-2, linked to proviral markers on chromosome 2, also influences the seizure phenotype. In addition, a potential modifier of seizures was detected in the DBA/2J background. The location of El-1 on distal chromosome 9 may allow identification of an epilepsy candidate gene in humans on the basis of conserved synteny with human chromosome 3.


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Genetic dissection of complex traits.
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Forward and reverse genetic approaches to behavior in the mouse.
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Science. ISSN 0036-8075 (print), 1095-9203 (online)