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Science 6 September 1991:
Vol. 253. no. 5024, pp. 1129 - 1132
DOI: 10.1126/science.1653454
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Articles

Science, Vol 253, Issue 5024, 1129-1132
Copyright © 1991 by American Association for the Advancement of Science

articles

Inhibition of neointimal smooth muscle accumulation after angioplasty by an antibody to PDGF

GA Ferns, EW Raines, KH Sprugel, AS Motani, MA Reidy, and R Ross

William Harvey Research Institute, St. Bartholomew's Hospital Medical College, London, United Kingdom.

Approximately 30 to 40 percent of atherosclerotic coronary arteries treated by angioplasty or by bypass surgery occlude as a result of restenosis. This restenosis is due principally to the accumulation of neointimal smooth muscle cells, which is also a prominent feature of the advanced lesions of atherosclerosis. The factors responsible for the accumulation of intimal smooth muscle cells have not been identified. Platelet-derived growth factor (PDGF) is a potent smooth muscle chemoattractant and mitogen. It is present in platelets and can be formed by endothelium, smooth muscle, and monocyte-derived macrophages. The development of an intimal lesion in the carotid artery of athymic nude rats induced by intraarterial balloon catheter deendothelialization was inhibited by a polyclonal antibody to PDGF. These data demonstrate that endogenous PDGF is involved in the accumulation of neointimal smooth muscle cells associated with balloon injury and may be involved in restenosis after angioplasty, and perhaps in atherogenesis as well.


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Increased Rate of Apoptosis in Intimal Arterial Smooth Muscle Cells Through Endogenous Activation of TNF Receptors.
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   Abstract »    Full Text »    PDF »
Intimal Hyperplasia Recurs After Removal of PDGF-AB and -BB Inhibition in the Rat Carotid Artery Injury Model.
O. Leppanen, N. Janjic, M.-A. Carlsson, K. Pietras, M. Levin, C. Vargeese, L. S. Green, D. Bergqvist, A. Ostman, and C.-H. Heldin (2000)
Arterioscler. Thromb. Vasc. Biol. 20 , e89-e95
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Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors.
E. Buchdunger, C. L. Cioffi, N. Law, D. Stover, S. Ohno-Jones, B. J. Druker, and N. B. Lydon (2000)
J. Pharmacol. Exp. Ther. 295, 139-145
   Abstract »    Full Text »
Induction of Lung Fibroblast Apoptosis by Soluble Fibronectin Peptides.
H. L. HADDEN and C. A. HENKE (2000)
Am. J. Respir. Crit. Care Med. 162, 1553-1560
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Increased migration in late G1 phase in cultured smooth muscle cells.
R. Fukui, M. Amakawa, M. Hoshiga, N. Shibata, E. Kohbayashi, M. Seto, Y. Sasaki, T. Ueno, N. Negoro, T. Nakakoji, et al. (2000)
Am J Physiol Cell Physiol 279, C999-C1007
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Novel Embryonic Genes Are Preferentially Expressed by Autonomously Replicating Rat Embryonic and Neointimal Smooth Muscle Cells.
M. C. M. Weiser-Evans, P. E. Schwartz, N. A. Grieshaber, B. E. Quinn, S. S. Grieshaber, J. K. Belknap, P. M. Mourani, R. A. Majack, and K. R. Stenmark (2000)
Circ. Res. 87, 608-615
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Bolus Endovascular PDGFR-{beta} Antisense Treatment Suppressed Intimal Hyperplasia in a Rat Carotid Injury Model.
N. Noiseux, C. H. Boucher, R. Cartier, and M. G. Sirois (2000)
Circulation 102, 1330-1336
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Attenuation of Experimental Proliferative Vitreoretinopathy by Inhibiting the Platelet-Derived Growth Factor Receptor.
Y. Ikuno, F.-L. Leong, and A. Kazlauskas (2000)
Invest. Ophthalmol. Vis. Sci. 41, 3107-3116