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Science 4 October 1991:
Vol. 254. no. 5028, pp. 51 - 58
DOI: 10.1126/science.1925561
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Articles

Science, Vol 254, Issue 5028, 51-58
Copyright © 1991 by American Association for the Advancement of Science

articles

Determination of macromolecular structures from anomalous diffraction of synchrotron radiation

WA Hendrickson

Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032.

Resonance between beams of x-ray waves and electronic transitions from bound atomic orbitals leads to a phenomenon known as anomalous scattering. This effect can be exploited in x-ray crystallographic studies on biological macromolecules by making diffraction measurements at selected wavelengths associated with a particular resonant transition. In this manner the problem of determining the three-dimensional structure of thousands of atoms is reduced to that of initially solving for a few anomalous scattering centers that can then be used as a reference for developing the entire structure. This method of multiwavelength anomalous diffraction has now been applied in a number of structure determinations. Optimal experiments require appropriate synchrotron instrumentation, careful experimental design, and sophisticated analytical procedures. There are rich opportunities for future applications.


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Science 282, 2215-2220
   Abstract »    Full Text »
X-ray Crystal Structure of the Fe-Only Hydrogenase (CpI) from Clostridium pasteurianum to 1.8 Angstrom Resolution.
J. W. Peters, W. N. Lanzilotta, B. J. Lemon, and L. C. Seefeldt (1998)
Science 282, 1853-1858
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Crystal structures of eukaryotic translation initiation factor 5A from Methanococcus jannaschii at 1.8 A resolution.
K. K. Kim, L.-W. Hung, H. Yokota, R. Kim, and S.-H. Kim (1998)
PNAS 95, 10419-10424
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The structure of the two amino-terminal domains of human ICAM-1 suggests how it functions as a rhinovirus receptor and as an LFA-1 integrin ligand.
J. Bella, P. R. Kolatkar, C. W. Marlor, J. M. Greve, and M. G. Rossmann (1998)
PNAS 95, 4140-4145
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Crystal structure of MTCP-1: Implications for role of TCL-1 and MTCP-1 in T cell malignancies.
Z.-Q. Fu, G. C. Du Bois, S. P. Song, I. Kulikovskaya, L. Virgilio, J. L. Rothstein, C. M. Croce, I. T. Weber, and R. W. Harrison (1998)
PNAS 95, 3413-3418
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Amidation of Bioactive Peptides: The Structure of Peptidylglycine alpha -Hydroxylating Monooxygenase.
S. T. Prigge, A. S. Kolhekar, B. A. Eipper, R. E. Mains, and L. M. Amzel (1997)
Science 278, 1300-1305
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Structure of Pit-1 POU domain bound to DNA as a dimer: unexpected arrangement and flexibility..
E M Jacobson, P Li, A Leon-del-Rio, M G Rosenfeld, and A K Aggarwal (1997)
Genes & Dev. 11, 198-212
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