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Science 11 October 1991:
Vol. 254. no. 5029, pp. 293 - 295
DOI: 10.1126/science.1656527
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Articles
Science, Vol 254, Issue 5029, 293-295
Copyright © 1991 by American Association for the Advancement of Science
Suppression of tumorigenicity in Wilms tumor by the p15.5-p14 region of chromosome 11
SF Dowdy,
CL Fasching,
D Araujo,
KM Lai,
E Livanos,
BE Weissman,
and
EJ Stanbridge
Department of Microbiology and Molecular Genetics, University of California, Irvine 92717.
Wilms tumor has been associated with genomic alterations at both the 11p13 and 11p15 regions. To differentiate between the involvement of these two loci, a chromosome 11 was constructed that had one or the other region deleted, and this chromosome was introduced into the tumorigenic Wilms tumor cell line G401. When assayed for tumor-forming activity in nude mice, the 11p13-deleted, but not the 11p15.5-p14.1-deleted chromosome, retained its ability to suppress tumor formation. These results provide in vivo functional evidence for the existence of a second genetic locus (WT2) involved in suppressing the tumorigenic phenotype of Wilms tumor.
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