Science 18 October 1991: Vol. 254. no. 5030, pp. 421 - 423 DOI: 10.1126/science.1925600

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Articles

Corticotropin-Releasing Hormone Deficiency Is Associated with Reduced Local Inflammation in a Mouse Model of Experimental Colitis.

J. Gay, E. Kokkotou, M. O'Brien, C. Pothoulakis, and K. P. Karalis (2008)
Endocrinology 149, 3403-3409
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Abortion is associated with increased expression of FasL in decidual leukocytes and apoptosis of extravillous trophoblasts: a role for CRH and urocortin.

V. Minas, U. Jeschke, S.N. Kalantaridou, D.U. Richter, T. Reimer, I. Mylonas, K. Friese, and A. Makrigiannakis (2007)
Mol. Hum. Reprod. 13, 663-673
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Gastric Vagal Efferent Inhibition Evoked by Intravenous CRF Is Unrelated to Simultaneously Recorded Vagal Afferent Activity in Urethane-Anesthetized Rats.

D. W. Adelson, H. P. Kosoyan, Y. Wang, J. Z. Steinberg, and Y. Tache (2007)
J Neurophysiol 97, 3004-3014
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Corticotropin releasing hormone and the immune/inflammatory response.

G. Mastorakos, E. I Karoutsou, and M. Mizamtsidi (2006)
Eur. J. Endocrinol. 155, S77-S84
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Corticotropin-releasing hormone receptor antagonists.

E Zoumakis, D K Grammatopoulos, and G P Chrousos (2006)
Eur. J. Endocrinol. 155, S85-S91
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Expression of urocortin in rat lung and its effect on pulmonary vascular permeability..

Y. Wu, Y. Xu, H. Zhou, J. Tao, and S. Li (2006)
J. Endocrinol. 189, 167-178
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Corticotropin-Releasing Factor and the Urocortins Induce the Expression of TLR4 in Macrophages via Activation of the Transcription Factors PU.1 and AP-1.

C. Tsatsanis, A. Androulidaki, T. Alissafi, I. Charalampopoulos, E. Dermitzaki, T. Roger, A. Gravanis, and A. N. Margioris (2006)
J. Immunol. 176, 1869-1877
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Regulation of corticotropin-releasing hormone receptor-2 expression in human cord blood-derived cultured mast cells.

N. G Papadopoulou, L. Oleson, D. Kempuraj, J. Donelan, C. L Cetrulo, and T. C Theoharides (2005)
J. Mol. Endocrinol. 35, R1-R8
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The role of nuclear factor kappa B in human labour.

T. M Lindstrom and P. R Bennett (2005)
Reproduction 130, 569-581
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Human Mast Cells Express Corticotropin-Releasing Hormone (CRH) Receptors and CRH Leads to Selective Secretion of Vascular Endothelial Growth Factor.

J. Cao, N. Papadopoulou, D. Kempuraj, W. S. Boucher, K. Sugimoto, C. L. Cetrulo, and T. C. Theoharides (2005)
J. Immunol. 174, 7665-7675
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From the Cover: Role of peripheral corticotropin-releasing factor and urocortin II in intestinal inflammation and motility in terminal ileum.

S. E. la Fleur, E. C. Wick, P. S. Idumalla, E. F. Grady, and A. Bhargava (2005)
PNAS 102, 7647-7652
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Corticotropin-Releasing Hormone Contributes to the Peripheral Inflammatory Response in Experimental Autoimmune Encephalomyelitis.

C. Benou, Y. Wang, J. Imitola, L. VanVlerken, C. Chandras, K. P. Karalis, and S. J. Khoury (2005)
J. Immunol. 174, 5407-5413
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Degranulation of mast cells located in median eminence in response to compound 48/80 evokes adrenocortical secretion via histamine and CRF in dogs.

I. Matsumoto, Y. Inoue, K. Tsuchiya, T. Shimada, and T. Aikawa (2004)
Am J Physiol Regulatory Integrative Comp Physiol 287, R969-R980
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Corticotropin-releasing hormone (CRH) requirement in Clostridium difficile toxin A-mediated intestinal inflammation.

P. M. Anton, J. Gay, A. Mykoniatis, A. Pan, M. O'Brien, D. Brown, K. Karalis, and C. Pothoulakis (2004)
PNAS 101, 8503-8508
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Corticotropin-Releasing Hormone and Its Structurally Related Urocortin Are Synthesized and Secreted by Human Mast Cells.

D. Kempuraj, N. G. Papadopoulou, M. Lytinas, M. Huang, K. Kandere-Grzybowska, B. Madhappan, W. Boucher, S. Christodoulou, A. Athanassiou, and T. C. Theoharides (2004)
Endocrinology 145, 43-48
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Cutting Edge: Requirement for Growth Hormone-Releasing Hormone in the Development of Experimental Autoimmune Encephalomyelitis.

H. Ikushima, M. Kanaoka, and S. Kojima (2003)
J. Immunol. 171, 2769-2772
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High Levels of Intrauterine Corticotropin-Releasing Hormone, Urocortin, Tryptase, and Interleukin-8 in Spontaneous Abortions.

B. Madhappan, D. Kempuraj, S. Christodoulou, S. Tsapikidis, W. Boucher, V. Karagiannis, A. Athanassiou, and T. C. Theoharides (2003)
Endocrinology 144, 2285-2290
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Corticotropin-Releasing Hormone and Brain Mast Cells Regulate Blood-Brain-Barrier Permeability Induced by Acute Stress.

P. Esposito, N. Chandler, K. Kandere, S. Basu, S. Jacobson, R. Connolly, D. Tutor, and T. C. Theoharides (2002)
J. Pharmacol. Exp. Ther. 303, 1061-1066
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Corticotropin-Releasing Hormone Augments Proinflammatory Cytokine Production from Macrophages In Vitro and in Lipopolysaccharide-Induced Endotoxin Shock in Mice.

S. Agelaki, C. Tsatsanis, A. Gravanis, and A. N. Margioris (2002)
Infect. Immun. 70, 6068-6074
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Regulation of Nuclear Factor-{kappa}B by Corticotropin-Releasing Hormone in Mouse Thymocytes.

J. Zhao and K. P. Karalis (2002)
Mol. Endocrinol. 16, 2561-2570
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Urocortin Expression in Synovium of Patients with Rheumatoid Arthritis and Osteoarthritis: Relation to Inflammatory Activity.

M. Kohno, Y. Kawahito, Y. Tsubouchi, A. Hashiramoto, R. Yamada, K.-i. Inoue, Y. Kusaka, T. Kubo, I. J. Elenkov, G. P. Chrousos, et al. (2001)
J. Clin. Endocrinol. Metab. 86, 4344-4352
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Cutaneous expression of corticotropin-releasing hormone (CRH), urocortin, and CRH receptors.

A. SLOMINSKI, J. WORTSMAN, A. PISARCHIK, B. ZBYTEK, E. A. LINTON, J. E. MAZURKIEWICZ, and E. T. WEI (2001)
FASEB J 15, 1678-1693
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A Genetic Model of Stress Displays Decreased Lymphocytes and Impaired Antibody Responses Without Altered Susceptibility to Streptococcus pneumoniae.

S. E. Murray, H. R. Lallman, A. D. Heard, M. B. Rittenberg, and M. P. Stenzel-Poore (2001)
J. Immunol. 167, 691-698
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Brain Mast Cells Act As an Immune Gate to the Hypothalamic-Pituitary-Adrenal Axis in Dogs.

I. Matsumoto, Y. Inoue, T. Shimada, and T. Aikawa (2001)
J. Exp. Med. 194, 71-78
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Formation of Proinflammatory Cytokines in Human Term Myometrium Is Stimulated by Lipopolysaccharide But Not by Corticotropin-Releasing Hormone.

B. Sehringer, W. R. Schäfer, B. Wetzka, W. R. Deppert, R. Brunner-Spahr, E. Benedek, and H. P. Zahradnik (2000)
J. Clin. Endocrinol. Metab. 85, 4859-4865
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The Sympathetic Nerve---An Integrative Interface between Two Supersystems: The Brain and the Immune System.

I. J. Elenkov, R. L. Wilder, G. P. Chrousos, and E. S. Vizi (2000)
Pharmacol. Rev. 52, 595-638
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Corticotropin Releasing Hormone and Proopiomelanocortin Involvement in the Cutaneous Response to Stress.

A. Slominski, J. Wortsman, T. Luger, R. Paus, and S. Solomon (2000)
Physiol Rev 80, 979-1020
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The stress response and the hypothalamic-pituitary-adrenal axis: from molecule to melancholia.

T.M. O'CONNOR, D.J. O'HALLORAN, and F. SHANAHAN (2000)
QJM 93, 323-333
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Corticotrophin-releasing hormone (CRH) interacts with inflammatory prostaglandins and interleukins and affects the decidualization of human endometrial stroma.

E. Zoumakis, A.N. Margioris, C. Stournaras, E. Dermitzaki, E. Angelakis, A. Makrigiannakis, E. Koumantakis, and A. Gravanis (2000)
Mol. Hum. Reprod. 6, 344-351
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Corticotropin-Releasing Hormone: A Potent Androgen Secretagogue in Girls with Hyperandrogenism after Precocious Pubarche.

(1999)
J. Clin. Endocrinol. Metab. 84, 4602-4606
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Urocortin Messenger Ribonucleic Acid: Tissue Distribution in the Rat and Regulation in Thymus by Lipopolysaccharide and Glucocorticoids.

K. Kageyama, M. J. Bradbury, L. Zhao, A. L. Blount, and W. W. Vale (1999)
Endocrinology 140, 5651-5658
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Human Umbilical Vein Endothelial Cells: A New Source and Potential Target for Corticotropin-Releasing Factor.

T. Simoncini, R. Apa, F. M. Reis, F. Miceli, M. Stomati, L. Driul, A. Lanzone, A. R. Genazzani, and F. Petraglia (1999)
J. Clin. Endocrinol. Metab. 84, 2802-2806
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Gender-Specific Exacerbation of Murine Lupus by Gonadotropin-Releasing Hormone: Potential Role of G{alpha}q/11.

J. D. Jacobson, M. A. Ansari, M. Kinealy, and V. Muthukrishnan (1999)
Endocrinology 140, 3429-3437
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Corticotropin-releasing hormone deficiency unmasks the proinflammatory effect of epinephrine.

K. P. Karalis, E. Kontopoulos, L. J. Muglia, and J. A. Majzoub (1999)
PNAS 96, 7093-7097
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Peripheral urocortin delays gastric emptying: role of CRF receptor 2.

T. Nozu, V. Martinez, J. Rivier, and Y. Tache (1999)
Am J Physiol Gastrointest Liver Physiol 276, G867-G874
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Mechanisms underlying the anti-inflammatory actions of central corticotropin-releasing factor.

M. Casadevall, E. Saperas, J. Panes, A. Salas, D. C. Anderson, J. R. Malagelada, and J. M. Pique (1999)
Am J Physiol Gastrointest Liver Physiol 276, G1016-G1026
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Potent Mast Cell Degranulation and Vascular Permeability Triggered by Urocortin Through Activation of Corticotropin-Releasing Hormone Receptors.

L. K. Singh, W. Boucher, X. Pang, R. Letourneau, D. Seretakis, M. Green, and T. C. Theoharides (1999)
J. Pharmacol. Exp. Ther. 288, 1349-1356
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Corticotropin-Releasing Factor Receptor 1 in Mouse Spleen: Expression After Immune Stimulation and Identification of Receptor-Bearing Cells.

M. Radulovic, F. M. Dautzenberg, S. Sydow, J. Radulovic, and J. Spiess (1999)
J. Immunol. 162, 3013-3021
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Peripheral corticotropin-releasing factor mediates the elevation of plasma IL-6 by immobilization stress in rats.

T. Ando, J. Rivier, H. Yanaihara, and A. Arimura (1998)
Am J Physiol Regulatory Integrative Comp Physiol 275, R1461-R1467
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A Neurotensin Receptor Antagonist Inhibits Acute Immobilization Stress-Induced Cardiac Mast Cell Degranulation, a Corticotropin-Releasing Hormone-Dependent Process.

X. Pang, N. Alexacos, R. Letourneau, D. Seretakis, W. Gao, W. Boucher, D. E. Cochrane, and T. C. Theoharides (1998)
J. Pharmacol. Exp. Ther. 287, 307-314
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Mast Cell Regulation of Human Endometrial Matrix Metalloproteinases: A Mechanism Underlying Menstruation.

J. Zhang, G. Nie, W. Jian, D. E. Woolley, and L. A. Salamonsen (1998)
Biol Reprod 59, 693-703
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Characterization of Corticotropin-Releasing Hormone (CRH) in Human Skin.

A. Slominski, G. Ermak, J. E. Mazurkiewicz, J. Baker, and J. Wortsman (1998)
J. Clin. Endocrinol. Metab. 83, 1020-1024
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Corticotropin-Releasing Factor Inhibits Luteinizing Hormone-Stimulated P450c17 Gene Expression and Androgen Production by Isolated Thecal Cells of Human Ovarian Follicles.

H. F. Erden, I. H. Zwain, H. Asakura, and S. S. C. Yen (1998)
J. Clin. Endocrinol. Metab. 83, 448-452
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Corticotropin-Releasing Hormone Induces Skin Mast Cell Degranulation and Increased Vascular Permeability, A Possible Explanation for Its Proinflammatory Effects.

T. C. Theoharides, L. K. Singh, W. Boucher, X. Pang, R. Letourneau, E. Webster, and G. Chrousos (1998)
Endocrinology 139, 403-413
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Corticotropin-Releasing Hormone (CRH) Inhibits Steroid Biosynthesis by Cultured Human Granulosa-Lutein Cells in a CRH and Interleukin-1 Receptor-Mediated Fashion.

L. Ghizzoni, G. Mastorakos, A. Vottero, A. Barreca, M. Furlini, A. Cesarone, B. Ferrari, G. P. Chrousos, and S. Bernasconi (1997)
Endocrinology 138, 4806-4811
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Expression of Genes Encoding Corticotropin-Releasing Factor (CRF), Type 1 CRF Receptor, and CRF-Binding Protein and Localization of the Gene Products in the Human Ovary.

H. Asakura, I. H. Zwain, and S. S. C. Yen (1997)
J. Clin. Endocrinol. Metab. 82, 2720-2725
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Expression of Corticotropin-Releasing Hormone and Its R1 receptor in Human Endometrial Stromal Cells.

A. M. Di Blasio, F. P. Giraldi, P. Vigano, F. Petraglia, M. Vignali, and F. Cavagnini (1997)
J. Clin. Endocrinol. Metab. 82, 1594-1597
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of Tumor Necrosis Factor-alpha Action within the CNS Markedly Reduces the Plasma Adrenocorticotropin Response to Peripheral Local Inflammation in Rats.

A. V. Turnbull, F. J. Pitossi, J.-J. Lebrun, S. Lee, J. C. Meltzer, D. M. Nance, A. del Rey, H. O. Besedovsky, and C. Rivier (1997)
J. Neurosci. 17, 3262-3273
 |  Abstract »  |  Full Text »  |  PDF »

The Hypothalamic-Pituitary-Adrenal Axis and Immune-Mediated Inflammation.

G. P. Chrousos (1995)
N. Engl. J. Med. 332, 1351-1363
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