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Science 25 October 1991:
Vol. 254. no. 5031, pp. 558 - 562
DOI: 10.1126/science.1683003
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Articles

Science, Vol 254, Issue 5031, 558-562
Copyright © 1991 by American Association for the Advancement of Science

articles

Activation of early gene expression in T lymphocytes by Oct-1 and an inducible protein, OAP40

KS Ullman, WM Flanagan, CA Edwards, and GR Crabtree

Department of Microbiology and Immunology, Stanford University, CA 94305.

After antigenic stimulation of T lymphocytes, genes essential for proliferation and immune function, such as the interleukin-2 (IL-2) gene, are transcriptionally activated. In both transient transfections and T lymphocyte-specific in vitro transcription, the homeodomain-containing protein Oct-1 participated in the inducible regulation of transcription of the IL-2 gene. Oct-1 functioned in this context with a 40-kilodalton protein called Oct-1-associated protein (OAP40). In addition to interacting specifically with DNA, OAP40 reduced the rate of dissociation of Oct-1 from its cognate DNA-binding site, suggesting that a direct interaction exists between Oct-1 and OAP40.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)