Related Content
Search Google Scholar for:
|
|
Science 25 October 1991:
Vol. 254. no. 5031, pp. 571 - 573
DOI: 10.1126/science.1658930
|
|
Articles
Science, Vol 254, Issue 5031, 571-573
Copyright © 1991 by American Association for the Advancement of Science
Dependence of kidney morphogenesis on the expression of nerve growth factor receptor
H Sariola,
M Saarma,
K Sainio,
U Arumae,
J Palgi,
A Vaahtokari,
I Thesleff,
and
A Karavanov
Department of Paediatric Pathology, Childrens' Hospital, University of Helsinki, Finland.
Nerve growth factor receptor (NGFR) serves as the binding site for the neurotrophic growth factors. Although NGFR has been found in several embryonic tissues outside the nervous system, the function of NGFR in embryogenesis of non-neuronal organs remains unknown. NGFR is transiently synthesized by embryonic rat kidney and disappears from nephrons upon their terminal differentiation. Anti-sense oligonucleotide inhibition of NGFR expression inhibits kidney morphogenesis. Therefore, NGFR is required not only for development of the nervous system, but also for differentiation of the kidney tubules.
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
- Neurotrophic Factor Neurotrophin-4 Regulates Ameloblastin Expression via Full-length TrkB.
- K. Yoshizaki, S. Yamamoto, A. Yamada, K. Yuasa, T. Iwamoto, E. Fukumoto, H. Harada, M. Saito, A. Nakasima, K. Nonaka, et al. (2008)
J. Biol. Chem.
283, 3385-3391
| Abstract »
| Full Text »
| PDF »
- Adult with progressive foot deformity.
- D S Kumar and L A Concepcion (2007)
Br. J. Radiol.
80, 384-387
| Full Text »
| PDF »
- Development of an siRNA-based method for repressing specific genes in renal organ culture and its use to show that the Wt1 tumour suppressor is required for nephron differentiation.
- J. A. Davies, M. Ladomery, P. Hohenstein, L. Michael, A. Shafe, L. Spraggon, and N. Hastie (2004)
Hum. Mol. Genet.
13, 235-246
| Abstract »
| Full Text »
| PDF »
- Autocrine Stimulation of Human Pancreatic Duct-like Development by Soluble Isoforms of Epimorphin In Vitro.
- L. Lehnert, M. M. Lerch, Y. Hirai, M.-L. Kruse, W. Schmiegel, and H. Kalthoff (2001)
J. Cell Biol.
152, 911-922
| Abstract »
| Full Text »
| PDF »
- A role for Timeless in epithelial morphogenesis during kidney development.
- Z. Li, R. O. Stuart, J. Qiao, A. Pavlova, K. T. Bush, M. Pohl, H. Sakurai, and S. K. Nigam (2000)
PNAS
97, 10038-10043
| Abstract »
| Full Text »
| PDF »
- An Increased Intraovarian Synthesis of Nerve Growth Factor and Its Low Affinity Receptor Is a Principal Component of Steroid-Induced Polycystic Ovary in the Rat.
- H. E. Lara, G. A. Dissen, V. Leyton, A. Paredes, H. Fuenzalida, J. L. Fiedler, and S. R. Ojeda (2000)
Endocrinology
141, 1059-1072
| Abstract »
| Full Text »
| PDF »
- Role of Neurotropins in Rat Embryonic Testis Morphogenesis (Cord Formation).
- E. Levine, A. S. Cupp, and M. K. Skinner (2000)
Biol Reprod
62, 132-142
| Abstract »
| Full Text »
- Spatiotemporal Patterns of Expression of Neurotrophins and Neurotrophin Receptors in Mice Suggest Functional Roles in Testicular and Epididymal Morphogenesis.
- M.A. Russo, M.L. Giustizieri, A. Favale, M.C. Fantini, L. Campagnolo, D. Konda, F. Germano, D. Farini, C. Manna, and G. Siracusa (1999)
Biol Reprod
61, 1123-1132
| Abstract »
| Full Text »
- A new role for neurotrophins: involvement of brain-derived neurotrophic factor and neurotrophin-4 in hair cycle control.
- V. A. BOTCHKAREV, N. V. BOTCHKAREVA, P. WELKER, M. METZ, G. R. LEWIN, A. SUBRAMANIAM, S. BULFONE-PAUS, E. HAGEN, A. BRAUN, M. LOMMATZSCH, et al. (1999)
FASEB J
13, 395-410
| Abstract »
| Full Text »
- Nerve growth factor regulates HCO-3 absorption in thick ascending limb: modifying effects of vasopressin.
- D. W. Good (1998)
Am J Physiol Cell Physiol
274, C931-C939
| Abstract »
| Full Text »
| PDF »
- Epimorphin Functions as a Key Morphoregulator for Mammary Epithelial Cells.
- Y. Hirai, A. Lochter, S. Galosy, S. Koshida, S. Niwa, and M. J. Bissell (1998)
J. Cell Biol.
140, 159-169
| Abstract »
| Full Text »
| PDF »
- Differential regulation of two sets of mesonephric tubules by WT-1.
- K Sainio, P Hellstedt, J. Kreidberg, L Saxen, and H Sariola (1997)
Development
124, 1293-1299
| Abstract »
| PDF »
- Expression of mRNAs for Neurotrophins and Their Receptors in Developing Rat Heart.
- J. O. Hiltunen, U. Arumae, M. Moshnyakov, and M. Saarma (1996)
Circ. Res.
79, 930-939
| Abstract »
| Full Text »
- Keratinocyte growth factor and its receptor are involved in regulating early lung branching.
- M Post, P Souza, J Liu, I Tseu, J Wang, M Kuliszewski, and A. Tanswell (1996)
Development
122, 3107-3115
| Abstract »
| PDF »
- Antisense oligodeoxynucleotides targeting PDGF-B mRNA inhibit cell proliferation during embryonic rat lung development.
- P Souza, L Sedlackova, M Kuliszewski, J Wang, J Liu, I Tseu, M Liu, A. Tanswell, and M Post (1994)
Development
120, 2163-2173
| Abstract »
| PDF »
- p75-deficient embryonic dorsal root sensory and neonatal sympathetic neurons display a decreased sensitivity to NGF.
- K. Lee, A. Davies, and R Jaenisch (1994)
Development
120, 1027-1033
| Abstract »
| PDF »
- Pax-2 is required for mesenchyme-to-epithelium conversion during kidney development.
- U. W. Rothenpieler and G. R. Dressler (1993)
Development
119, 711-720
| Abstract »
| PDF »
- Antisense oligonucleotides as therapeutic agents--is the bullet really magical?.
- C. Stein and Y. Cheng (1993)
Science
261, 1004-1012
| Abstract »
| PDF »
- Regulation of expression of mRNAs encoding the nerve growth factor receptors p75 and trkA in developing sensory neurons.
- S Wyatt and A. Davies (1993)
Development
119, 635-648
| Abstract »
| PDF »
- Antisense inhibition of AMEL translation demonstrates supramolecular controls for enamel HAP crystal growth during embryonic mouse molar development.
- T Diekwisch, S David, P Bringas, V Santos, and H. Slavkin (1993)
Development
117, 471-482
| Abstract »
| PDF »
|
|
