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Science 8 November 1991:
Vol. 254. no. 5033, pp. 860 - 862
DOI: 10.1126/science.1948066
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Articles

Science, Vol 254, Issue 5033, 860-862
Copyright © 1991 by American Association for the Advancement of Science

articles

Selective depletion in HIV infection of T cells that bear specific T cell receptor V beta sequences

L Imberti, A Sottini, A Bettinardi, M Puoti, and D Primi

Consorzio per le Biotecnologie-Consiglio Nazionale delle Ricerche-Institute of Chemistry, School of Medicine, University of Brescia, Italy.

The mechanism of T cell depletion during infection with the human immunodeficiency virus (HIV) is unclear. Examination of the repertoire of T cell receptor V (variable) regions in persons infected with HIV revealed the absence of a common set of V beta regions, whereas V alpha usage was normal. The lack of these V beta segments did not appear to correlate with opportunistic infections. The selective elimination of T cells that express a defined set of V beta sequences may indicate the presence of an HIV-encoded superantigen, similar to those encoded by the long terminal repeat of the mouse mammary tumor virus.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)