Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Oxford Global

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 15 November 1991:
Vol. 254. no. 5034, pp. 1014 - 1016
DOI: 10.1126/science.1948071
Prev | Table of Contents | Next

Articles

Science, Vol 254, Issue 5034, 1014-1016
Copyright © 1991 by American Association for the Advancement of Science

articles

Oscillations of cytosolic sodium during calcium oscillations in exocrine acinar cells

MM Wong and JK Foskett

Division of Cell Biology, Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada.

In acinar cells from rat salivary glands, cholinergic agonists cause oscillations in cytoplasmic free calcium concentration, which then drive oscillations of cell volume that reflect oscillating cell solute content and fluid secretion. By quantitative fluorescence ratio microscopy of an intracellular indicator dye for sodium, it has now been shown that large amplitude oscillations of sodium concentration were associated with the calcium and cell volume oscillations. Both calcium and sodium oscillations were dependent on the continued presence of calcium in the extracellular medium and were abolished by the specific sodium-potassium adenosine triphosphatase inhibitor ouabain. Thus, calcium oscillations in salivary acinar cells, by modulating the activities of ion transport pathways in the plasma membrane, can cause significant oscillations of monovalent ions that may in turn feed back to regulate calcium oscillations and fluid secretion.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Sodium-Potassium-Chloride Cotransport.
J. M. Russell (2000)
Physiol Rev 80, 211-276
   Abstract »    Full Text »    PDF »
Na+-H+ exchange in salivary secretory cells is controlled by an intracellular Na+ receptor.
H. Ishibashi, A. Dinudom, K. F. Harvey, S. Kumar, J. A. Young, and D. I. Cook (1999)
PNAS 96, 9949-9953
   Abstract »    Full Text »    PDF »
Functional Significance of Cell Volume Regulatory Mechanisms.
F. LANG, G. L. BUSCH, M. RITTER, H. VOLKL, S. WALDEGGER, E. GULBINS, and D. HAUSSINGER (1998)
Physiol Rev 78, 247-306
   Abstract »    Full Text »    PDF »
Mechanism of fluid transport across corneal endothelium and other epithelial layers: a possible explanation based on cyclic cell volume regulatory changes.
J. FISCHBARG (1997)
Br. J. Ophthalmol. 81, 85-89
   Full Text »    PDF »
Na+-dependent Release of Mg2+ from an Intracellular Pool in Rat Sublingual Mucous Acini.
G. H. Zhang and J. E. Melvin (1996)
J. Biol. Chem. 271, 29067-29072
   Abstract »    Full Text »    PDF »
Chloride-dependent cation conductance activated during cellular shrinkage.
H. Chan and D. Nelson (1992)
Science 257, 669-671
   Abstract »    PDF »


ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)