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Science 15 November 1991:
Vol. 254. no. 5034, pp. 1022 - 1024
DOI: 10.1126/science.1658940
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Articles

Science, Vol 254, Issue 5034, 1022-1024
Copyright © 1991 by American Association for the Advancement of Science

articles

Expression cloning of an adenylate cyclase-coupled calcitonin receptor

HY Lin, TL Harris, MS Flannery, A Aruffo, EH Kaji, A Gorn, LF Kolakowski Jr, HF Lodish, and Goldring SR

Whitehead Institute for Biomedical Research, Cambridge, MA 02142.

A calcitonin receptor complementary DNA (cDNA) was cloned by expression of a cDNA library from a porcine kidney epithelial cell line in COS cells. The 482-amino acid receptor has high affinity for salmon calcitonin (dissociation constant Kd approximately 6 nM) and is functionally coupled to increases in intracellular cyclic adenosine monophosphate (cAMP). The receptor shows no sequence similarity to other reported G protein-coupled receptors but is homologous to the parathyroid hormone-parathyroid hormone-related peptide (PTH-PTHrP) receptor, indicating that the receptors for these hormones, which regulate calcium homeostasis, represent a new family of G protein-coupled receptors.


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alpha -Latrotoxin Receptor, Latrophilin, Is a Novel Member of the Secretin Family of G Protein-coupled Receptors.
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Constitutive Activation of the Cyclic Adenosine 3',5'-Monophosphate Signaling Pathway by Parathyroid Hormone (PTH)/PTH-Related Peptide Receptors Mutated at the Two Loci for Jansen's Metaphyseal Chondrodysplasia.
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T. K. Chatterjee, X. Liu, R. L. Davisson, and R. A. Fisher (1997)
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Molecular Mechanisms of Ligand Interaction with the Gonadotropin-Releasing Hormone Receptor.
S. C. Sealfon, H. Weinstein, and R. P. Millar (1997)
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Human Calcitonin Receptors Exhibit Agonist-Independent (Constitutive) Signaling Activity.
D. P. Cohen, C. N. Thaw, A. Varma, M. C. Gershengorn, and D. R. Nussenzveig (1997)
Endocrinology 138, 1400-1405
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Mutations in the Second Cytoplasmic Loop of the Rat Parathyroid Hormone (PTH)/PTH-related Protein Receptor Result in Selective Loss of PTH-stimulated Phospholipase C Activity.
A. Iida-Klein, J. Guo, M. Takemura, M. T. Drake, J. T. Potts Jr., A. Abou-Samra, F. R. Bringhurst, and G. V. Segre (1997)
J. Biol. Chem. 272, 6882-6889
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Regulation by Calcitonin and Glucocorticoids of Calcitonin Receptor Gene Expression in Mouse Osteoclasts.
S. Wada, N. Udagawa, T. Akatsu, N. Nagata, T. J. Martin, and D. M. Findlay (1997)
Endocrinology 138, 521-529
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Electrophoretic Mobility and Glycosylation Characteristics of Heterogeneously Expressed Calcitonin Receptors.
M. Quiza, M. Dowton, K. J. Perry, and P. M. Sexton (1997)
Endocrinology 138, 530-539
   Abstract »    Full Text »    PDF »
Molecular Cloning of a Novel Variant of the Pituitary Adenylate Cyclase-activating Polypeptide (PACAP) Receptor That Stimulates Calcium Influx by Activation of L-type Calcium Channels.
T. K. Chatterjee, R. V. Sharma, and R. A. Fisher (1996)
J. Biol. Chem. 271, 32226-32232
   Abstract »    Full Text »    PDF »
The Deletion of 14Amino Acids in the Seventh Transmembrane Domain of a Naturally Occurring Calcitonin Receptor Isoform Alters Ligand Binding and Selectively Abolishes Coupling to Phospholipase C.
J.-F. Shyu, D. Inoue, R. Baron, and W. C. Horne (1996)
J. Biol. Chem. 271, 31127-31134
   Abstract »    Full Text »    PDF »
Full Activation of Chimeric Receptors by Hybrids between Parathyroid Hormone and Calcitonin. EVIDENCE FOR A COMMON PATTERN OF LIGAND-RECEPTOR INTERACTION.
C. Bergwitz, T. J. Gardella, M. R. Flannery, J. T. Potts Jr., H. M. Kronenberg, S. R. Goldring, and H. Juppner (1996)
J. Biol. Chem. 271, 26469-26472
   Abstract »    Full Text »    PDF »
Transmembrane Regions V and VI of the Human Luteinizing Hormone Receptor Are Required for Constitutive Activation by a Mutation in the Third Intracellular Loop.
M. Kudo, Y. Osuga, B. K. Kobilka, and A. J.W. Hsueh (1996)
J. Biol. Chem. 271, 22470-22478
   Abstract »    Full Text »    PDF »
Converting Parathyroid Hormone-related Peptide (PTHrP) into a Potent PTH-2 Receptor Agonist.
T. J. Gardella, M. D. Luck, G. S. Jensen, T. B. Usdin, and H. Juppner (1996)
J. Biol. Chem. 271, 19888-19893
   Abstract »    Full Text »    PDF »
Transmembrane Residues of the Parathyroid Hormone (PTH)/PTH-related Peptide Receptor That Specifically Affect Binding and Signaling by Agonist Ligands.
T. J. Gardella, M. D. Luck, M.-H. Fan, and C. Lee (1996)
J. Biol. Chem. 271, 12820-12825
   Abstract »    Full Text »    PDF »
A cDNA Encoding the Calcitonin Gene-related Peptide Type 1 Receptor.
N. Aiyar, K. Rand, N. A. Elshourbagy, Z. Zeng, J. E. Adamou, D. J. Bergsma, and Y. Li (1996)
J. Biol. Chem. 271, 11325-11329
   Abstract »    Full Text »    PDF »
Characterization of Deletion and Truncation Mutants of the Rat Glucagon Receptor.
C. G. Unson, A. M. Cypess, H. N. Kim, P. K. Goldsmith, C. J. L. Carruthers, R. B. Merrifield, and T. P. Sakmar (1995)
J. Biol. Chem. 270, 27720-27727
   Abstract »    Full Text »    PDF »
Calcitonin Increases Cytosolic Free Calcium Concentration via Capacitative Calcium Influx.
A. Teti, R. Paniccia, and S. R. Goldring (1995)
J. Biol. Chem. 270, 16666-16670
   Abstract »    Full Text »    PDF »
Critical Contributions of Amino-terminal Extracellular Domains in Agonist Binding and Activation of Secretin and Vasoactive Intestinal Polypeptide Receptors.
M. H. Holtmann, E. M. Hadac, and L. J. Miller (1995)
J. Biol. Chem. 270, 14394-14398
   Abstract »    Full Text »    PDF »
Truncation of the Carboxyl-terminal Region of the Rat Parathyroid Hormone (PTH)/PTH-related Peptide Receptor Enhances PTH Stimulation of Adenylyl Cyclase but Not Phospholipase C.
A. Iida-Klein, J. Guo, L. Y. Xie, H. Jüppner, J. T. Potts Jr., H. M. Kronenberg, F. R. Bringhurst, A. B. Abou-Samra, and G. V. Segre (1995)
J. Biol. Chem. 270, 8458-8465
   Abstract »    Full Text »    PDF »
Expression cloning and signaling properties of the rat glucagon receptor.
L. Jelinek, S Lok, G. Rosenberg, R. Smith, F. Grant, S Biggs, P. Bensch, J. Kuijper, P. Sheppard, C. Sprecher, et al. (1993)
Science 259, 1614-1616
   Abstract »    PDF »
The cloning of a family of genes that encode the melanocortin receptors.
K. Mountjoy, L. Robbins, M. Mortrud, and R. Cone (1992)
Science 257, 1248-1251
   Abstract »    PDF »
Tissue-specific and Ubiquitous Promoters Direct the Expression of Alternatively Spliced Transcripts from the Calcitonin Receptor Gene.
O. Anusaksathien, C. Laplace, X. Li, Y. Ren, L. Peng, S. R. Goldring, and D. L. Galson (2001)
J. Biol. Chem. 276, 22663-22674
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)