Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Science Signaling

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 22 November 1991:
Vol. 254. no. 5035, pp. 1153 - 1160
DOI: 10.1126/science.1957167
Prev | Table of Contents | Next

Articles

Science, Vol 254, Issue 5035, 1153-1160
Copyright © 1991 by American Association for the Advancement of Science

articles

Chromosome aberrations and cancer

E Solomon, J Borrow, and AD Goddard

Somatic Cell Genetics Laboratory, Imperial Cancer Research Fund, London, United Kingdom.

Cancer may be defined as a progressive series of genetic events that occur in a single clone of cells because of alterations in a limited number of specific genes: the oncogenes and tumor suppressor genes. The association of consistent chromosome aberrations with particular types of cancer has led to the identification of some of these genes and the elucidation of their mechanisms of action. Consistent chromosome aberrations are observed not only in rare tumor types but also in the relatively common lung, colon, and breast cancers. Identification of additional mutated genes through other chromosomal abnormalities will lead to a more complete molecular description of oncogenesis.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Estrogens and genomic instability in human breast cancer cells--involvement of Src/Raf/Erk signaling in micronucleus formation by estrogenic chemicals.
A. Kabil, E. Silva, and A. Kortenkamp (2008)
Carcinogenesis 29, 1862-1868
   Abstract »    Full Text »    PDF »
Cytokinesis-Blocked Micronucleus Cytome Assay Biomarkers Identify Lung Cancer Cases Amongst Smokers.
R. A. El-Zein, M. Fenech, M. S. Lopez, M. R. Spitz, and C. J. Etzel (2008)
Cancer Epidemiol. Biomarkers Prev. 17, 1111-1119
   Abstract »    Full Text »    PDF »
Cytokinesis-blocked micronucleus assay as a novel biomarker for lung cancer risk..
R. A. El-Zein, M. B. Schabath, C. J. Etzel, M. S. Lopez, J. D. Franklin, and M. R. Spitz (2006)
Cancer Res. 66, 6449-6456
   Abstract »    Full Text »    PDF »
Chromosomal Instability in Peripheral Blood Lymphocytes and Risk of Prostate Cancer.
R. El-Zein, Y. Gu, M. S. Sierra, M. R. Spitz, and S. S. Strom (2005)
Cancer Epidemiol. Biomarkers Prev. 14, 748-752
   Abstract »    Full Text »    PDF »
Mitotic Arrest Deficient 2 Expression Induces Chemosensitization to a DNA-Damaging Agent, Cisplatin, in Nasopharyngeal Carcinoma Cells.
H. W. Cheung, D.-Y. Jin, M.-t. Ling, Y. C. Wong, Q. Wang, S. W. Tsao, and X. Wang (2005)
Cancer Res. 65, 1450-1458
   Abstract »    Full Text »    PDF »
Elevated expression of the AF1q gene, an MLL fusion partner, is an independent adverse prognostic factor in pediatric acute myeloid leukemia.
W. Tse, S. Meshinchi, T. A. Alonzo, D. L. Stirewalt, R. B. Gerbing, W. G. Woods, F. R. Appelbaum, and J. P. Radich (2004)
Blood 104, 3058-3063
   Abstract »    Full Text »    PDF »
Polymorphisms of folate metabolic genes and susceptibility to bladder cancer: a case-control study.
J. Lin, M. R. Spitz, Y. Wang, M. B. Schabath, I. P. Gorlov, L. M. Hernandez, P. C. Pillow, H. B. Grossman, and X. Wu (2004)
Carcinogenesis 25, 1639-1647
   Abstract »    Full Text »    PDF »
The Contribution of Genetic and Epigenetic Changes in Granulosa Cell Tumors of Ovarian Origin.
V. S. Dhillon, M. Aslam, and S. A. Husain (2004)
Clin. Cancer Res. 10, 5537-5545
   Abstract »    Full Text »    PDF »
A Common Variant of the Methylenetetrahydrofolate Reductase Gene (1p36) Is Associated with an Increased Risk of Cancer.
B. T. Heijmans, J. M. A. Boer, H. E. D. Suchiman, C. J. Cornelisse, R. G. J. Westendorp, D. Kromhout, E. J. M. Feskens, and P. E. Slagboom (2003)
Cancer Res. 63, 1249-1253
   Abstract »    Full Text »    PDF »
Mutations in Drosophila myb lead to centrosome amplification and genomic instability.
S.-M. Fung, G. Ramsay, and A. L. Katzen (2003)
Development 129, 347-359
   Abstract »    Full Text »    PDF »
Evidence for position effects as a variant ETV6-mediated leukemogenic mechanism in myeloid leukemias with a t(4;12)(q11-q12;p13) or t(5;12)(q31;p13).
J. Cools, N. Mentens, M. D. Odero, P. Peeters, I. Wlodarska, M. Delforge, A. Hagemeijer, and P. Marynen (2002)
Blood 99, 1776-1784
   Abstract »    Full Text »    PDF »
A novel gene, NSD1, is fused to NUP98 in the t(5;11)(q35;p15.5) in de novo childhood acute myeloid leukemia.
R. J. Jaju, C. Fidler, O. A. Haas, A. J. Strickson, F. Watkins, K. Clark, N. C. P. Cross, J.-F. Cheng, P. D. Aplan, L. Kearney, et al. (2001)
Blood 98, 1264-1267
   Abstract »    Full Text »    PDF »
Loss of Expression and Aberrant Methylation of the CDH13 (H-Cadherin) Gene in Breast and Lung Carcinomas.
K. O. Toyooka, S. Toyooka, A. K. Virmani, U. G. Sathyanarayana, D. M. Euhus, M. Gilcrease, J. D. Minna, and A. F. Gazdar (2001)
Cancer Res. 61, 4556-4560
   Abstract »    Full Text »    PDF »
Analytical Variables of Reverse Transcription-Polymerase Chain Reaction-based Detection of Disseminated Prostate Cancer Cells.
A. Zippelius, R. Lutterbüse, G. Riethmüller, and K. Pantel (2000)
Clin. Cancer Res. 6, 2741-2750
   Abstract »    Full Text »
Constitutive Stat3, Tyr705, and Ser727 phosphorylation in acute myeloid leukemia cells caused by the autocrine secretion of interleukin-6.
J.-J. Schuringa, A. T. J. Wierenga, W. Kruijer, and E. Vellenga (2000)
Blood 95, 3765-3770
   Abstract »    Full Text »    PDF »
Measurement of locus copy number by hybridisation with amplifiable probes.
J. A. L. Armour, C. Sismani, P. C. Patsalis, and G. Cross (2000)
Nucleic Acids Res. 28, 605-609
   Abstract »    Full Text »    PDF »
Recurrent alterations of the short arm of chromosome 3 define a tumor suppressor region in rat mammary tumor cells.
N. C. Popescu and J. W. Greiner (1999)
Carcinogenesis 20, 2033-2036
   Abstract »    Full Text »    PDF »
Cloning and Characterization of the EAP30 Subunit of the ELL Complex That Confers Derepression of Transcription by RNA Polymerase II.
A. E. Schmidt, T. Miller, S. L. Schmidt, R. Shiekhattar, and A. Shilatifard (1999)
J. Biol. Chem. 274, 21981-21985
   Abstract »    Full Text »    PDF »
A New Recurrent Translocation, t(5;11)(q35;p15.5), Associated With del(5q) in Childhood Acute Myeloid Leukemia.
R. J. Jaju, O. A. Haas, M. Neat, J. Harbott, V. Saha, J. Boultwood, J. M. Brown, H. Pirc-Danoewinata, B. W. Krings, U. Muller, et al. (1999)
Blood 94, 773-780
   Abstract »    Full Text »    PDF »
A Novel Signature Mutation for Oxidative Damage Resembles a Mutational Pattern Found Commonly in Human Cancers.
M. S. Turker, B. M. Gage, J. A. Rose, D. Elroy, O. N. Ponomareva, P. J. Stambrook, and J. A. Tischfield (1999)
Cancer Res. 59, 1837-1839
   Abstract »    Full Text »    PDF »
The t(6;8)(q27;p11) Translocation in a Stem Cell Myeloproliferative Disorder Fuses a Novel Gene, FOP, to Fibroblast Growth Factor Receptor 1.
C. Popovici, B. Zhang, M.-J. Gregoire, P. Jonveaux, M. Lafage-Pochitaloff, D. Birnbaum, and M.-J. Pebusque (1999)
Blood 93, 1381-1389
   Abstract »    Full Text »    PDF »
Molecular Cloning of Translocation t(1;14)(q21;q32) Defines a Novel Gene (BCL9) at Chromosome 1q21.
T.G. Willis, I.R. Zalcberg, L.J.A. Coignet, I. Wlodarska, M. Stul, D.M. Jadayel, C. Bastard, J.G. Treleaven, D. Catovsky, M.L.M. Silva, et al. (1998)
Blood 91, 1873-1881
   Abstract »    Full Text »    PDF »
Oncogenic Transcription Factors in the Human Acute Leukemias.
A. T. Look (1997)
Science 278, 1059-1064
   Abstract »    Full Text »
Cancer of Unknown Primary Origin.
E. Briasoulis and N. Pavlidis (1997)
Oncologist 2, 142-152
   Abstract »    Full Text »    PDF »
Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: Implications for cancer and neuronal damage.
B. C. Blount, M. M. Mack, C. M. Wehr, J. T. MacGregor, R. A. Hiatt, G. Wang, S. N. Wickramasinghe, R. B. Everson, and B. N. Ames (1997)
PNAS 94, 3290-3295
   Abstract »    Full Text »    PDF »
Detection of Genetic Loss in Tumors by Representational Difference Analysis.
N.A. Lisitsyn, F.S. Leach, B. Vogelstein, and M.H. Wigler (1994)
Cold Spring Harb Symp Quant Biol 59, 585-587
   Abstract »    PDF »
Acute Promyelocytic Leukemia.
R. P. Warrell, H. de The, Z.-Y. Wang, and L. Degos (1993)
N. Engl. J. Med. 329, 177-189
   Full Text »
Transcription factors junB and c-jun are selectively up-regulated and functionally implicated in fibrosarcoma development..
E Bossy-Wetzel, R Bravo, and D Hanahan (1992)
Genes & Dev. 6, 2340-2351
   Abstract »    PDF »
Fusion of the leucine zipper gene HLF to the E2A gene in human acute B-lineage leukemia.
T Inaba, W. Roberts, L. Shapiro, K. Jolly, S. Raimondi, S. Smith, and A. Look (1992)
Science 257, 531-534
   Abstract »    PDF »
Transgenic models of tumor development.
J. Adams and S Cory (1991)
Science 254, 1161-1167
   Abstract »    PDF »
Tel-2 Is a Novel Transcriptional Repressor Related to the Ets Factor Tel/ETV-6.
X. Gu, B.-H. Shin, Y. Akbarali, A. Weiss, J. Boltax, P. Oettgen, and T. A. Libermann (2001)
J. Biol. Chem. 276, 9421-9436
   Abstract »    Full Text »    PDF »


ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)