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Science 22 November 1991:
Vol. 254. no. 5035, pp. 1208 - 1210
DOI: 10.1126/science.1957172
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Articles

Science, Vol 254, Issue 5035, 1208-1210
Copyright © 1991 by American Association for the Advancement of Science

articles

Hypotensive activity of fibroblast growth factor

P Cuevas, F Carceller, S Ortega, M Zazo, I Nieto, and G Gimenez-Gallego

Hospital Universitario Ramon y Cajal, Carretera de Colmenar, Madrid, Spain.

Acidic and basic fibroblast growth factors (FGFs) are members of a family of proteins that are broad-spectrum mitogens, have diverse hormone-like activities, and function in tumorigenesis. FGF's ability to raise the concentration of intracellular calcium ion suggests that FGF could induce the synthesis of endothelium-derived relaxing factor (EDRF) and consequently vasodilation. Systemic administration of FGF decreased arterial blood pressure. This effect was mediated by EDRF and by adenosine triphosphate-sensitive potassium ion channels. The hypotensive effect of FGF was segregated from its mitogenic activity by protein engineering. These results extend the range of FGF autocrine activities and potential therapeutic applications, emphasize the role of endothelium as an arterial blood pressure--regulating organ, and provide insight on the structural basis of FGF functions.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)