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Science 29 November 1991:
Vol. 254. no. 5036, pp. 1312 - 1319
DOI: 10.1126/science.1962191
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Articles

Science, Vol 254, Issue 5036, 1312-1319
Copyright © 1991 by American Association for the Advancement of Science

articles

Molecular self-assembly and nanochemistry: a chemical strategy for the synthesis of nanostructures

GM Whitesides, JP Mathias, and CT Seto

Department of Chemistry, Harvard University, Cambridge, MA 02138.

Molecular self-assembly is the spontaneous association of molecules under equilibrium conditions into stable, structurally well-defined aggregates joined by noncovalent bonds. Molecular self-assembly is ubiquitous in biological systems and underlies the formation of a wide variety of complex biological structures. Understanding self-assembly and the associated noncovalent interactions that connect complementary interacting molecular surfaces in biological aggregates is a central concern in structural biochemistry. Self-assembly is also emerging as a new strategy in chemical synthesis, with the potential of generating nonbiological structures with dimensions of 1 to 10(2) nanometers (with molecular weights of 10(4) to 10(10) daltons). Structures in the upper part of this range of sizes are presently inaccessible through chemical synthesis, and the ability to prepare them would open a route to structures comparable in size (and perhaps complementary in function) to those that can be prepared by microlithography and other techniques of microfabrication.


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P. S. Corbin, L. J. Lawless, Z. Li, Y. Ma, M. J. Witmer, and S. C. Zimmerman (2002)
PNAS 99, 5099-5104
   Abstract »    Full Text »    PDF »
Supramolecular Chemistry And Self-assembly Special Feature: Partial shell-filled core-shell tecto(dendrimers): A strategy to surface differentiated nano-clefts and cusps.
D. A. Tomalia, H. M. Brothers II, L. T. Piehler, H. D. Durst, and D. R. Swanson (2002)
PNAS 99, 5081-5087
   Abstract »    Full Text »    PDF »
Supramolecular Chemistry And Self-assembly Special Feature: Toward complex matter: Supramolecular chemistry and self-organization.
J.-M. Lehn (2002)
PNAS 99, 4763-4768
   Full Text »    PDF »
Molecular self-assembly of surfactant-like peptides to form nanotubes and nanovesicles.
S. Vauthey, S. Santoso, H. Gong, N. Watson, and S. Zhang (2002)
PNAS 99, 5355-5360
   Abstract »    Full Text »    PDF »
Supramolecular Chemistry And Self-assembly Special Feature: Hierarchical formation of helical supramolecular polymers via stacking of hydrogen-bonded pairs in water.
L. Brunsveld, J. A. J. M. Vekemans, J. H. K. K. Hirschberg, R. P. Sijbesma, and E. W. Meijer (2002)
PNAS 99, 4977-4982
   Abstract »    Full Text »    PDF »
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J. D. Hartgerink, E. Beniash, and S. I. Stupp (2002)
PNAS 99, 5133-5138
   Abstract »    Full Text »    PDF »


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