Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 6 December 1991:
Vol. 254. no. 5037, pp. 1471 - 1477
DOI: 10.1126/science.1962206
Prev | Table of Contents | Next

Articles

Science, Vol 254, Issue 5037, 1471-1477
Copyright © 1991 by American Association for the Advancement of Science

articles

The atom economy--a search for synthetic efficiency

BM Trost

Department of Chemistry, Stanford University, CA 94305-5080.

Efficient synthetic methods required to assemble complex molecular arrays include reactions that are both selective (chemo-, regio-, diastereo-, and enantio-) and economical in atom count (maximum number of atoms of reactants appearing in the products). Methods that involve simply combining two or more building blocks with any other reactant needed only catalytically constitute the highest degree of atom economy. Transition metal-catalyzed methods that are both selective and economical for formation of cyclic structures, of great interest for biological purposes, represent an important starting point for this long-term goal. The limited availability of raw materials, combined with environmental concerns, require the highlighting of these goals.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Green chemistry for chemical synthesis.
C.-J. Li and B. M. Trost (2008)
PNAS 105, 13197-13202
   Abstract »    Full Text »    PDF »
Green Chemistry as Social Movement?.
E. J. Woodhouse and S. Breyman (2005)
Science Technology Human Values 30, 199-222
   Abstract »    PDF »
Asymmetric Catalysis Special Feature Part II: Enantioselective direct aldol reactions catalyzed by L-prolinamide derivatives.
Z. Tang, F. Jiang, X. Cui, L.-Z. Gong, A.-Q. Mi, Y.-Z. Jiang, and Y.-D. Wu (2004)
PNAS 101, 5755-5760
   Abstract »    Full Text »    PDF »
Solid Phase Ring-opening Polymerization of Macrocyclic S-Aryl Thioesters Containing Terephthaloyl Structure.
A. Kameyama, T. Ide, and T. Nishikubo (2003)
High Performance Polymers 15, 207-218
   Abstract »    PDF »
Green, Catalytic Oxidation of Alcohols in Water.
G. t. Brink, I. W. Arends, and R. A. Sheldon (2000)
Science 287, 1636-1639
   Abstract »    Full Text »


ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)