Related Content
Search Google Scholar for:
|
|
Science 13 December 1991: Vol. 254. no. 5038, pp. 1598 - 1603 DOI: 10.1126/science.1749933
|
|
Articles
Science, Vol 254, Issue 5038, 1598-1603
Copyright © 1991 by American Association for the Advancement of Science
The energy landscapes and motions of proteins
H Frauenfelder,
SG Sligar,
and
PG Wolynes
Center for Advanced Study, University of Illinois, Champaign, Urbana 61801.
Recent experiments, advances in theory, and analogies to other complex systems such as glasses and spin glasses yield insight into protein dynamics. The basis of the understanding is the observation that the energy landscape is complex: Proteins can assume a large number of nearly isoenergetic conformations (conformational substates). The concepts that emerge from studies of the conformational substates and the motions between them permit a quantitative discussion of one simple reaction, the binding of small ligands such as carbon monoxide to myoglobin.
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
- Hemoglobin Dynamics in Red Blood Cells: Correlation to Body Temperature.
- A. M. Stadler, I. Digel, G. M. Artmann, J. P. Embs, G. Zaccai, and G. Buldt (2008)
Biophys. J.
95, 5449-5461
| Abstract »
| Full Text »
| PDF »
- The Effect of Temperature on Mechanical Resistance of the Native and Intermediate States of I27.
- Y. Taniguchi, D. J. Brockwell, and M. Kawakami (2008)
Biophys. J.
95, 5296-5305
| Abstract »
| Full Text »
| PDF »
- Computing the stability diagram of the Trp-cage miniprotein.
- D. Paschek, S. Hempel, and A. E. Garcia (2008)
PNAS
105, 17754-17759
| Abstract »
| Full Text »
| PDF »
- Observations on Rate Theory for Rugged Energy Landscapes.
- E. Pollak, A. Auerbach, and P. Talkner (2008)
Biophys. J.
95, 4258-4265
| Abstract »
| Full Text »
| PDF »
- Hydrophobe-Water Interactions: Methane as a Model.
- F. Despa and R. S. Berry (2008)
Biophys. J.
95, 4241-4245
| Abstract »
| Full Text »
| PDF »
- Pressure Effects on the Ensemble Dynamics of Ubiquitin Inspected with Molecular Dynamics Simulations and Isotropic Reorientational Eigenmode Dynamics.
- N. G. Sgourakis, R. Day, S. A. McCallum, and A. E. Garcia (2008)
Biophys. J.
95, 3943-3955
| Abstract »
| Full Text »
| PDF »
- Seven Transmembrane Receptors as Nature's Prototype Allosteric Protein: De-emphasizing the Geography of Binding.
- T. P. Kenakin (2008)
Mol. Pharmacol.
74, 541-543
| Abstract »
| Full Text »
| PDF »
- Potential landscape and flux framework of nonequilibrium networks: Robustness, dissipation, and coherence of biochemical oscillations.
- J. Wang, L. Xu, and E. Wang (2008)
PNAS
105, 12271-12276
| Abstract »
| Full Text »
| PDF »
- Modulation of actin structure and function by phosphorylation of Tyr-53 and profilin binding.
- K. Baek, X. Liu, F. Ferron, S. Shu, E. D. Korn, and R. Dominguez (2008)
PNAS
105, 11748-11753
| Abstract »
| Full Text »
| PDF »
- Shoot-and-Trap: Use of specific x-ray damage to study structural protein dynamics by temperature-controlled cryo-crystallography.
- J.-P. Colletier, D. Bourgeois, B. Sanson, D. Fournier, J. L. Sussman, I. Silman, and M. Weik (2008)
PNAS
105, 11742-11747
| Abstract »
| Full Text »
| PDF »
- Dynamic energy landscape view of coupled binding and protein conformational change: Induced-fit versus population-shift mechanisms.
- K.-i. Okazaki and S. Takada (2008)
PNAS
105, 11182-11187
| Abstract »
| Full Text »
| PDF »
- From the Cover: Hierarchical organization of eglin c native state dynamics is shaped by competing direct and water-mediated interactions.
- C. K. Materese, C. C. Goldmon, and G. A. Papoian (2008)
PNAS
105, 10659-10664
| Abstract »
| Full Text »
| PDF »
- Competing interactions create functionality through frustration.
- V. Lubchenko (2008)
PNAS
105, 10635-10636
| Full Text »
| PDF »
- Extracting function from a {beta}-trefoil folding motif.
- S. Gosavi, P. C. Whitford, P. A. Jennings, and J. N. Onuchic (2008)
PNAS
105, 10384-10389
| Abstract »
| Full Text »
| PDF »
- Hydration Dependence of Active Core Fluctuations in Bacteriorhodopsin.
- K. Wood, U. Lehnert, B. Kessler, G. Zaccai, and D. Oesterhelt (2008)
Biophys. J.
95, 194-202
| Abstract »
| Full Text »
| PDF »
- Direct observation of fast protein conformational switching.
- H. Ishikawa, K. Kwak, J. K. Chung, S. Kim, and M. D. Fayer (2008)
PNAS
105, 8619-8624
| Abstract »
| Full Text »
| PDF »
- Being uncomfortable..
- P. A. Robbins, B. Suki, J. J. Fredberg, F. E. Yates, J. H. T. Bates, T. Similowski, L. Glass, and A. J. E. Seely (2008)
J Appl Physiol
104, 1848-1849
| Full Text »
| PDF »
- Induced-fit or preexisting equilibrium dynamics? Lessons from protein crystallography and MD simulations on acetylcholinesterase and implications for structure-based drug design.
- Y. Xu, J. Ph. Colletier, H. Jiang, I. Silman, J. L. Sussman, and M. Weik (2008)
Protein Sci.
17, 601-605
| Abstract »
| Full Text »
| PDF »
- Molecular Dynamics Simulations of Hemoglobin A in Different States and Bound to DPG: Effector-Linked Perturbation of Tertiary Conformations and HbA Concerted Dynamics.
- M. Laberge and T. Yonetani (2008)
Biophys. J.
94, 2737-2751
| Abstract »
| Full Text »
| PDF »
- Spectral Dynamics of Individual Bacterial Light-Harvesting Complexes: Alternative Disorder Model.
- J. Janusonis, L. Valkunas, D. Rutkauskas, and R. van Grondelle (2008)
Biophys. J.
94, 1348-1358
| Abstract »
| Full Text »
| PDF »
- Multiscale complex network of protein conformational fluctuations in single-molecule time series.
- C.-B. Li, H. Yang, and T. Komatsuzaki (2008)
PNAS
105, 536-541
| Abstract »
| Full Text »
| PDF »
- A Mining Minima Approach to Exploring the Docking Pathways of p-Nitrocatechol Sulfate to YopH.
- Z. Huang and C. F. Wong (2007)
Biophys. J.
93, 4141-4150
| Abstract »
| Full Text »
| PDF »
- Localizing frustration in native proteins and protein assemblies.
- D. U. Ferreiro, J. A. Hegler, E. A. Komives, and P. G. Wolynes (2007)
PNAS
104, 19819-19824
| Abstract »
| Full Text »
| PDF »
- Construction of effective free energy landscape from single-molecule time series.
- A. Baba and T. Komatsuzaki (2007)
PNAS
104, 19297-19302
| Abstract »
| Full Text »
| PDF »
- Coarse-Grained Biomolecular Simulation with REACH: Realistic Extension Algorithm via Covariance Hessian.
- K. Moritsugu and J. C. Smith (2007)
Biophys. J.
93, 3460-3469
| Abstract »
| Full Text »
| PDF »
- Coupling of protein and hydration-water dynamics in biological membranes.
- K. Wood, M. Plazanet, F. Gabel, B. Kessler, D. Oesterhelt, D. J. Tobias, G. Zaccai, and M. Weik (2007)
PNAS
104, 18049-18054
| Abstract »
| Full Text »
| PDF »
- Illuminating the mechanistic roles of enzyme conformational dynamics.
- J. A. Hanson, K. Duderstadt, L. P. Watkins, S. Bhattacharyya, J. Brokaw, J.-W. Chu, and H. Yang (2007)
PNAS
104, 18055-18060
| Abstract »
| Full Text »
| PDF »
- Mutations as trapdoors to two competing native conformations of the Rop-dimer.
- A. Schug, P. C. Whitford, Y. Levy, and J. N. Onuchic (2007)
PNAS
104, 17674-17679
| Abstract »
| Full Text »
| PDF »
- Configuration-dependent diffusion can shift the kinetic transition state and barrier height of protein folding.
- J. Chahine, R. J. Oliveira, V. B. P. Leite, and J. Wang (2007)
PNAS
104, 14646-14651
| Abstract »
| Full Text »
| PDF »
- Protein folding and unfolding studied at atomic resolution by fast two-dimensional NMR spectroscopy.
- P. Schanda, V. Forge, and B. Brutscher (2007)
PNAS
104, 11257-11262
| Abstract »
| Full Text »
| PDF »
- Bacteriorhodopsin photocycle at cryogenic temperatures reveals distributed barriers of conformational substates.
- A. K. Dioumaev and J. K. Lanyi (2007)
PNAS
104, 9621-9626
| Abstract »
| Full Text »
| PDF »
- Quantifying Robustness and Dissipation Cost of Yeast Cell Cycle Network: The Funneled Energy Landscape Perspectives.
- B. Han and J. Wang (2007)
Biophys. J.
92, 3755-3763
| Abstract »
| Full Text »
| PDF »
- Molecular evolution of affinity and flexibility in the immune system.
- I. F. Thorpe and C. L. Brooks III (2007)
PNAS
104, 8821-8826
| Abstract »
| Full Text »
| PDF »
- Signatures of hydrophobic collapse in extended proteins captured with force spectroscopy.
- K. A. Walther, F. Grater, L. Dougan, C. L. Badilla, B. J. Berne, and J. M. Fernandez (2007)
PNAS
104, 7916-7921
| Abstract »
| Full Text »
| PDF »
- Influence of the Redox Potential of the Primary Quinone Electron Acceptor on Photoinhibition in Photosystem II.
- C. Fufezan, C. M. Gross, M. Sjodin, A. W. Rutherford, A. Krieger-Liszkay, and D. Kirilovsky (2007)
J. Biol. Chem.
282, 12492-12502
| Abstract »
| Full Text »
| PDF »
- Dissection of complex protein dynamics in human thioredoxin.
- W. Qiu, L. Wang, W. Lu, A. Boechler, D. A. R. Sanders, and D. Zhong (2007)
PNAS
104, 5366-5371
| Abstract »
| Full Text »
| PDF »
- Evidence of Discrete Substates and Unfolding Pathways in Green Fluorescent Protein.
- G. Baldini, F. Cannone, G. Chirico, M. Collini, B. Campanini, S. Bettati, and A. Mozzarelli (2007)
Biophys. J.
92, 1724-1731
| Abstract »
| Full Text »
| PDF »
- Establishing the entatic state in folding metallated Pseudomonas aeruginosa azurin.
- C. Zong, C. J. Wilson, T. Shen, P. Wittung-Stafshede, S. L. Mayo, and P. G. Wolynes (2007)
PNAS
104, 3159-3164
| Abstract »
| Full Text »
| PDF »
- Loop formation in unfolded polypeptide chains on the picoseconds to microseconds time scale.
- B. Fierz, H. Satzger, C. Root, P. Gilch, W. Zinth, and T. Kiefhaber (2007)
PNAS
104, 2163-2168
| Abstract »
| Full Text »
| PDF »
- From the Cover: Complex network analysis of free-energy landscapes.
- D. Gfeller, P. De Los Rios, A. Caflisch, and F. Rao (2007)
PNAS
104, 1817-1822
| Abstract »
| Full Text »
| PDF »
- Inaugural Article: Connecting nitrogenase intermediates with the kinetic scheme for N2 reduction by a relaxation protocol and identification of the N2 binding state.
- D. Lukoyanov, B. M. Barney, D. R. Dean, L. C. Seefeldt, and B. M. Hoffman (2007)
PNAS
104, 1451-1455
| Abstract »
| Full Text »
| PDF »
- Metastable Mesoscopic Clusters in Solutions of Sickle-Cell Hemoglobin.
- W. Pan, O. Galkin, L. Filobelo, R. L. Nagel, and P. G. Vekilov (2007)
Biophys. J.
92, 267-277
| Abstract »
| Full Text »
| PDF »
- A backbone-based theory of protein folding.
- G. D. Rose, P. J. Fleming, J. R. Banavar, and A. Maritan (2006)
PNAS
103, 16623-16633
| Abstract »
| Full Text »
| PDF »
- Stretching the Immunoglobulin 27 Domain of the Titin Protein: The Dynamic Energy Landscape.
- N. Duff, N.-H. Duong, and D. J. Lacks (2006)
Biophys. J.
91, 3446-3455
| Abstract »
| Full Text »
| PDF »
- Protein complex formation by acetylcholinesterase and the neurotoxin fasciculin-2 appears to involve an induced-fit mechanism.
- J. M. Bui and J. A. McCammon (2006)
PNAS
103, 15451-15456
| Abstract »
| Full Text »
| PDF »
- Protein folding is slaved to solvent motions.
- H. Frauenfelder, P. W. Fenimore, G. Chen, and B. H. McMahon (2006)
PNAS
103, 15469-15472
| Abstract »
| Full Text »
| PDF »
- Partitioning of Anesthetics into a Lipid Bilayer and their Interaction with Membrane-Bound Peptide Bundles.
- S. Vemparala, L. Saiz, R. G. Eckenhoff, and M. L. Klein (2006)
Biophys. J.
91, 2815-2825
| Abstract »
| Full Text »
| PDF »
- Two ligand-binding sites in the O2-sensing signal transducer HemAT: Implications for ligand recognition/discrimination and signaling.
- E. Pinakoulaki, H. Yoshimura, V. Daskalakis, S. Yoshioka, S. Aono, and C. Varotsis (2006)
PNAS
103, 14796-14801
| Abstract »
| Full Text »
| PDF »
- A Structure-Based Simulation Approach for Electron Paramagnetic Resonance Spectra Using Molecular and Stochastic Dynamics Simulations.
- C. Beier and H.-J. Steinhoff (2006)
Biophys. J.
91, 2647-2664
| Abstract »
| Full Text »
| PDF »
- Antibody evolution constrains conformational heterogeneity by tailoring protein dynamics.
- J. Zimmermann, E. L. Oakman, I. F. Thorpe, X. Shi, P. Abbyad, C. L. Brooks III, S. G. Boxer, and F. E. Romesberg (2006)
PNAS
103, 13722-13727
| Abstract »
| Full Text »
| PDF »
- Funneled Landscape Leads to Robustness of Cellular Networks: MAPK Signal Transduction.
- J. Wang, B. Huang, X. Xia, and Z. Sun (2006)
Biophys. J.
91, L54-L56
| Abstract »
| Full Text »
| PDF »
- Sulfide-Binding Hemoglobins: Effects of Mutations on Active-Site Flexibility.
- S. Fernandez-Alberti, D. E. Bacelo, R. C. Binning Jr., J. Echave, M. Chergui, and J. Lopez-Garriga (2006)
Biophys. J.
91, 1698-1709
| Abstract »
| Full Text »
| PDF »
- Hierarchic Finite Level Energy Landscape Model: TO DESCRIBE THE REFOLDING KINETICS OF PHOSPHOGLYCERATE KINASE.
- S. Osvath, L. Herenyi, P. Zavodszky, J. Fidy, and G. Kohler (2006)
J. Biol. Chem.
281, 24375-24380
| Abstract »
| Full Text »
| PDF »
- Complementarity of ensemble and single-molecule measures of protein motion: A relaxation dispersion NMR study of an enzyme complex.
- P. Vallurupalli and L. E. Kay (2006)
PNAS
103, 11910-11915
| Abstract »
| Full Text »
| PDF »
- Quantifying the Kinetic Paths of Flexible Biomolecular Recognition.
- J. Wang, K. Zhang, H. Lu, and E. Wang (2006)
Biophys. J.
91, 866-872
| Abstract »
| Full Text »
| PDF »
- A two-dimensional view of the folding energy landscape of cytochrome c.
- J. H. Werner, R. Joggerst, R. B. Dyer, and P. M. Goodwin (2006)
PNAS
103, 11130-11135
| Abstract »
| Full Text »
| PDF »
- Controlling the Protein Dynamical Transition with Sugar-Based Bioprotectant Matrices: A Neutron Scattering Study.
- E. Cornicchi, M. Marconi, G. Onori, and A. Paciaroni (2006)
Biophys. J.
91, 289-297
| Abstract »
| Full Text »
| PDF »
- Low-Temperature Glass Transitions of Quenched and Annealed Bovine Serum Albumin Aqueous Solutions.
- K. Kawai, T. Suzuki, and M. Oguni (2006)
Biophys. J.
90, 3732-3738
| Abstract »
| Full Text »
| PDF »
- Reorientational Contact-Weighted Elastic Network Model for the Prediction of Protein Dynamics: Comparison with NMR Relaxation.
- D. Ming and R. Bruschweiler (2006)
Biophys. J.
90, 3382-3388
| Abstract »
| Full Text »
| PDF »
- Protein Grabs a Ligand by Extending Anchor Residues: Molecular Simulation for Ca2+ Binding to Calmodulin Loop.
- C. Kobayashi and S. Takada (2006)
Biophys. J.
90, 3043-3051
| Abstract »
| Full Text »
| PDF »
- The inherent structure landscape of a protein.
- N. Nakagawa and M. Peyrard (2006)
PNAS
103, 5279-5284
| Abstract »
| Full Text »
| PDF »
- Spectral Trends in the Fluorescence of Single Bacterial Light-Harvesting Complexes: Experiments and Modified Redfield Simulations.
- D. Rutkauskas, V. Novoderezhkin, A. Gall, J. Olsen, R. J. Cogdell, C. N. Hunter, and R. van Grondelle (2006)
Biophys. J.
90, 2475-2485
| Abstract »
| Full Text »
| PDF »
- Hydration Dependence of Conformational Dielectric Relaxation of Lysozyme.
- J. Knab, J.-Y. Chen, and A. Markelz (2006)
Biophys. J.
90, 2576-2581
| Abstract »
| Full Text »
| PDF »
- Extended subnanosecond structural dynamics of myoglobin revealed by Laue crystallography.
- D. Bourgeois, B. Vallone, A. Arcovito, G. Sciara, F. Schotte, P. A. Anfinrud, and M. Brunori (2006)
PNAS
103, 4924-4929
| Abstract »
| Full Text »
| PDF »
- The Fe-CO Bond Energy in Myoglobin: A QM/MM Study of the Effect of Tertiary Structure.
- N. Strickland, A. J. Mulholland, and J. N. Harvey (2006)
Biophys. J.
90, L27-L29
| Abstract »
| Full Text »
| PDF »
- Novel Conformational States of Peptide Deformylase from Pathogenic Bacterium Leptospira interrogans: IMPLICATIONS FOR POPULATION SHIFT.
- Z. Zhou, X. Song, and W. Gong (2005)
J. Biol. Chem.
280, 42391-42396
| Abstract »
| Full Text »
| PDF »
- Reorganization and Conformational Changes in the Reduction of Tetraheme Cytochromes.
- A. S. F. Oliveira, V. H. Teixeira, A. M. Baptista, and C. M. Soares (2005)
Biophys. J.
89, 3919-3930
| Abstract »
| Full Text »
| PDF »
- The Position 68(E11) Side Chain in Myoglobin Regulates Ligand Capture, Bond Formation with Heme Iron, and Internal Movement into the Xenon Cavities.
- D. Dantsker, C. Roche, U. Samuni, G. Blouin, J. S. Olson, and J. M. Friedman (2005)
J. Biol. Chem.
280, 38740-38755
| Abstract »
| Full Text »
| PDF »
- Liquid-Like Water Confined in Stacks of Biological Membranes at 200 K and Its Relation to Protein Dynamics.
- M. Weik, U. Lehnert, and G. Zaccai (2005)
Biophys. J.
89, 3639-3646
| Abstract »
| Full Text »
| PDF »
- Conformational dependence of a protein kinase phosphate transfer reaction.
- G. Henkelman, M. X. LaBute, C.-S. Tung, P. W. Fenimore, and B. H. McMahon (2005)
PNAS
102, 15347-15351
| Abstract »
| Full Text »
| PDF »
- Single-molecule Forster resonance energy transfer study of protein dynamics under denaturing conditions.
- E. V. Kuzmenkina, C. D. Heyes, and G. U. Nienhaus (2005)
PNAS
102, 15471-15476
| Abstract »
| Full Text »
| PDF »
- Identification of slow correlated motions in proteins using residual dipolar and hydrogen-bond scalar couplings.
- G. Bouvignies, P. Bernado, S. Meier, K. Cho, S. Grzesiek, R. Bruschweiler, and M. Blackledge (2005)
PNAS
102, 13885-13890
| Abstract »
| Full Text »
| PDF »
- Pre-Unfolding Resonant Oscillations of Single Green Fluorescent Protein Molecules.
- G. Baldini, F. Cannone, and G. Chirico (2005)
Science
309, 1096-1100
| Abstract »
| Full Text »
| PDF »
- Functional conformational motions in the turnover cycle of cholesterol oxidase.
- H.-P. Lerch, R. Rigler, and A. S. Mikhailov (2005)
PNAS
102, 10807-10812
| Abstract »
| Full Text »
| PDF »
- Gating of proton and water transfer in the respiratory enzyme cytochrome c oxidase.
- M. Wikstrom, C. Ribacka, M. Molin, L. Laakkonen, M. Verkhovsky, and A. Puustinen (2005)
PNAS
102, 10478-10481
| Abstract »
| Full Text »
| PDF »
- History-Dependent Multiple-Time-Scale Dynamics in a Single-Neuron Model.
- G. Gilboa, R. Chen, and N. Brenner (2005)
J. Neurosci.
25, 6479-6489
| Abstract »
| Full Text »
| PDF »
- Exploring the Common Dynamics of Homologous Proteins. Application to the Globin Family.
- S. Maguid, S. Fernandez-Alberti, L. Ferrelli, and J. Echave (2005)
Biophys. J.
89, 3-13
| Abstract »
| Full Text »
| PDF »
- Protein dynamics control proton transfer from bulk solvent to protein interior: A case study with a green fluorescent protein.
- A. M. Saxena, J. B. Udgaonkar, and G. Krishnamoorthy (2005)
Protein Sci.
14, 1787-1799
| Abstract »
| Full Text »
| PDF »
- Fluctuations and Correlations in Crystalline Protein Dynamics: A Simulation Analysis of Staphylococcal Nuclease.
- L. Meinhold and J. C. Smith (2005)
Biophys. J.
88, 2554-2563
| Abstract »
| Full Text »
| PDF »
- Charge Recombination and Thermoluminescence in Photosystem II.
- F. Rappaport, A. Cuni, L. Xiong, R. Sayre, and J. Lavergne (2005)
Biophys. J.
88, 1948-1958
| Abstract »
| Full Text »
| PDF »
- From the Cover: Human myoglobin recognition of oxygen: Dynamics of the energy landscape.
- Y. Wang, J. S. Baskin, T. Xia, and A. H. Zewail (2004)
PNAS
101, 18000-18005
| Abstract »
| Full Text »
| PDF »
- A Two-Dimensional Infrared Study of Localization, Structure, and Dynamics of a Dipeptide in Membrane Environment.
- V. Volkov and P. Hamm (2004)
Biophys. J.
87, 4213-4225
| Abstract »
| Full Text »
| PDF »
- Probing the Kinetics of Single Molecule Protein Folding.
- V. B. P. Leite, J. N. Onuchic, G. Stell, and J. Wang (2004)
Biophys. J.
87, 3633-3641
| Abstract »
| Full Text »
| PDF »
- Unveiling functional protein motions with picosecond x-ray crystallography and molecular dynamics simulations.
- G. Hummer, F. Schotte, and P. A. Anfinrud (2004)
PNAS
101, 15330-15334
| Abstract »
| Full Text »
| PDF »
- Dynamical transition and proteinquake in photoactive yellow protein.
- K. Itoh and M. Sasai (2004)
PNAS
101, 14736-14741
| Abstract »
| Full Text »
| PDF »
- Bulk-solvent and hydration-shell fluctuations, similar to {alpha}- and {beta}-fluctuations in glasses, control protein motions and functions.
- P. W. Fenimore, H. Frauenfelder, B. H. McMahon, and R. D. Young (2004)
PNAS
101, 14408-14413
| Abstract »
| Full Text »
| PDF »
- The Complex Kinetics of Protein Folding in Wide Temperature Ranges.
- J. Wang (2004)
Biophys. J.
87, 2164-2171
| Abstract »
| Full Text »
| PDF »
- Downhill Kinetics of Biomolecular Interface Binding: Globally Connected Scenario.
- J. Wang, W. Huang, H. Lu, and E. Wang (2004)
Biophys. J.
87, 2187-2194
| Abstract »
| Full Text »
| PDF »
- From the Cover: Domain swapping is a consequence of minimal frustration.
- S. Yang, S. S. Cho, Y. Levy, M. S. Cheung, H. Levine, P. G. Wolynes, and J. N. Onuchic (2004)
PNAS
101, 13786-13791
| Abstract »
| Full Text »
| PDF »
- Viscosity-dependent Relaxation Significantly Modulates the Kinetics of CO Recombination in the Truncated Hemoglobin TrHbN from Mycobacterium tuberculosis.
- D. Dantsker, U. Samuni, Y. Ouellet, B. A. Wittenberg, J. B. Wittenberg, M. Milani, M. Bolognesi, M. Guertin, and J. M. Friedman (2004)
J. Biol. Chem.
279, 38844-38853
| Abstract »
| Full Text »
| PDF »
- Neutron Frequency Windows and the Protein Dynamical Transition.
- T. Becker, J. A. Hayward, J. L. Finney, R. M. Daniel, and J. C. Smith (2004)
Biophys. J.
87, 1436-1444
| Abstract »
| Full Text »
| PDF »
- A single-amino-acid lid renders a gas-tight compartment within a membrane-bound transporter.
- L. Salomonsson, A. Lee, R. B. Gennis, and P. Brzezinski (2004)
PNAS
101, 11617-11621
| Abstract »
| |