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Science 13 December 1991:
Vol. 254. no. 5038, pp. 1654 - 1656
DOI: 10.1126/science.1749937
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Articles
Science, Vol 254, Issue 5038, 1654-1656
Copyright © 1991 by American Association for the Advancement of Science
Intracellular signaling by 14-hydroxy-4,14-retro-retinol
J Buck,
F Derguini,
E Levi,
K Nakanishi,
and
U Hammerling
Department of Immunology, Memorial Sloan-Kettering Cancer Center, New York, New York 10021.
In mammals, retinol is the precursor for retinoids, which affect various aspects of morphogenesis and development. However, B lymphocytes, although retinol-dependent, do not use retinoic acid as mediator. Retinol is metabolized by B lymphocytes and other cell lines to optically active 14-hydroxy-4,14-retro-retinol; it is this compound that mediates the growth control. Thus another second messenger molecule, in addition to retinoic acid and retinal, is derived from retinol.
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