Related Content
Search Google Scholar for:
|
|
Science 20 December 1991:
Vol. 254. no. 5039, pp. 1756 - 1761
DOI: 10.1126/science.1763324
|
|
Articles
Science, Vol 254, Issue 5039, 1756-1761
Copyright © 1991 by American Association for the Advancement of Science
Linkage of faulty major histocompatibility complex class I to autoimmune diabetes
D Faustman,
XP Li,
HY Lin,
YE Fu,
G Eisenbarth,
J Avruch,
and
J Guo
Department of Medicine, Harvard Medical School, Massachusetts General Hospital, Charlestown 02129.
Pancreatic islet cells are the targets of an autoimmune response in type I diabetes. In the nonobese diabetic (NOD) mouse model of autoimmune diabetes, expression of major histocompatibility complex (MHC) class I proteins was inversely correlated with diabetes; in this mouse a mutation in the MHC class II-linked gene for the putative MHC class I peptide transporter was also present. Mice deficient in MHC class I expression because they do not produce beta 2-microglobulin also developed late onset autoimmune diabetes. In cells from humans with type I diabetes expression of MHC class I was decreased; subsets of prediabetics categorized as most likely to become hyperglycemic also had low MHC class I. T cell responses to self antigens are faulty in diabetics. In sets of genetically identical twins that are discordant for diabetes, the defect appeared to reside with the antigen presenting cell. Thus, a lack of surface MHC class I protein is associated with autoimmune diabetes; the concomitant defect in antigen presentation may impair the development of self tolerance, which could result in autoimmune disease.
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
- Immunotherapy on Trial for New-Onset Type 1 Diabetes.
- D. L. Faustman (2008)
N. Engl. J. Med.
359, 1956-1958
| Full Text »
| PDF »
- Selective death of autoreactive T cells in human diabetes by TNF or TNF receptor 2 agonism.
- L. Ban, J. Zhang, L. Wang, W. Kuhtreiber, D. Burger, and D. L. Faustman (2008)
PNAS
105, 13644-13649
| Abstract »
| Full Text »
| PDF »
- Reversal of Sjogren's-like syndrome in non-obese diabetic mice.
- S. D Tran, S. Kodama, B. M Lodde, I. Szalayova, S. Key, S. Khalili, D. L Faustman, and E. Mezey (2007)
Ann Rheum Dis
66, 812-814
| Abstract »
| Full Text »
| PDF »
- Prediction of HLA-DQ3.2{beta} Ligands: evidence of multiple registers in class II binding peptides.
- J. C. Tong, G. L. Zhang, T. W. Tan, J. T. August, V. Brusic, and S. Ranganathan (2006)
Bioinformatics
22, 1232-1238
| Abstract »
| Full Text »
| PDF »
- Major Histocompatibility Complex Class I Shedding and Programmed Cell Death Stimulated Through the Proinflammatory P2X7 Receptor: A Candidate Susceptibility Gene for NOD Diabetes.
- J. I. Elliott and C. F. Higgins (2004)
Diabetes
53, 2012-2017
| Abstract »
| Full Text »
| PDF »
- Islet Regeneration During the Reversal of Autoimmune Diabetes in NOD Mice.
- S. Kodama, W. Kuhtreiber, S. Fujimura, E. A. Dale, and D. L. Faustman (2003)
Science
302, 1223-1227
| Abstract »
| Full Text »
| PDF »
- Role of Defective Apoptosis in Type 1 Diabetes and Other Autoimmune Diseases.
- T. Hayashi and D. L. Faustman (2003)
Recent Prog. Horm. Res.
58, 131-153
| Abstract »
| Full Text »
| PDF »
- Genome and Hormones: Gender Differences in Physiology: Selected Contribution: Association of gender-related LMP2 inactivation with autoimmune pathogenesis.
- T. Hayashi and D. L. Faustman (2001)
J Appl Physiol
91, 2804-2815
| Abstract »
| Full Text »
| PDF »
- Homotypic cluster formation of dendritic cells, a close correlate of their state of maturation. Defects in the biobreeding diabetes-prone rat.
- F. G. A. Delemarre, P. G. Hoogeveen, M. de Haan-Meulman, P. J. Simons, and H. A. Drexhage (2001)
J. Leukoc. Biol.
69, 373-380
| Abstract »
| Full Text »
- NOD Mice Are Defective in Proteasome Production and Activation of NF-kappa B.
- T. Hayashi and D. Faustman (1999)
Mol. Cell. Biol.
19, 8646-8659
| Abstract »
| Full Text »
| PDF »
- Signs of Immaturity of Splenic Dendritic Cells from the Autoimmune Prone Biobreeding Rat: Consequences for the In Vitro Expansion of Regulator and Effector T Cells.
- F. G. A. Delemarre, P. J. Simons, H. J. de Heer, and H. A. Drexhage (1999)
J. Immunol.
162, 1795-1801
| Abstract »
| Full Text »
| PDF »
- Novel Splicing of the Human MHC-Encoded Peptide Transporter Confers Unique Properties.
- G. Yan, L. Shi, and D. Faustman (1999)
J. Immunol.
162, 852-859
| Abstract »
| Full Text »
| PDF »
- Subcongenic Analysis of the Idd13 Locus in NOD/Lt Mice: Evidence for Several Susceptibility Genes Including a Possible Diabetogenic Role for {beta}2-Microglobulin.
- D. V. Serreze, M. Bridgett, H. D. Chapman, E. Chen, S. D. Richard, and E. H. Leiter (1998)
J. Immunol.
160, 1472-1478
| Abstract »
| Full Text »
| PDF »
- The Pathogenesis of Insulin-Dependent Diabetes Mellitus.
- M. A. Atkinson and N. K. Maclaren (1994)
N. Engl. J. Med.
331, 1428-1436
| Full Text »
- Expression of intra-MHC transporter (Ham) genes and class I antigens in diabetes-susceptible NOD mice.
- H. Gaskins, J. Monaco, and E. Leiter (1992)
Science
256, 1826-1828
| PDF »
- Expression of intra-MHC transporter (Ham) genes and class I antigens in diabetes-susceptible NOD mice.
- L. Wicker, P. Podolin, P Fischer, A Sirotina, R. Boltz Jr, and L. Peterson (1992)
Science
256, 1828-1830
| PDF »
- Response.
- D. Faustman, X. Li, H. Y. Lin, R. Huang, and J. Guo (1992)
Science
256, 1830-1831
| PDF »
|
|
