Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 3 July 1992:
Vol. 257. no. 5066, pp. 50 - 56
DOI: 10.1126/science.1621094

Articles

Science, Vol 257, Issue 5066, 50-56
Copyright © 1992 by American Association for the Advancement of Science


articles

Neurexins: synaptic cell surface proteins related to the alpha-latrotoxin receptor and laminin

YA Ushkaryov, AG Petrenko, M Geppert, and TC Sudhof

Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas 75235.

A family of highly polymorphic neuronal cell surface proteins, the neurexins, has been identified. At least two genes for neurexins exist. Each gene uses alternative promoters and multiple variably spliced exons to potentially generate more than a 100 different neurexin transcripts. The neurexins were discovered by the identification of one member of the family as the receptor for alpha-latrotoxin. This toxin is a component of the venom from black widow spiders; it binds to presynaptic nerve terminals and triggers massive neurotransmitter release. Neurexins contain single transmembrane regions and extracellular domains with repeated sequences similar to sequences in laminin A, slit, and agrin, proteins that have been implicated in axon guidance and synaptogenesis. An antibody to neurexin I showed highly concentrated immunoreactivity at the synapse. The polymorphic structure of the neurexins, their neural localization, and their sequence similarity to proteins associated with neurogenesis suggest a function as cell recognition molecules in the nerve terminal.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Polarized Targeting of Neurexins to Synapses Is Regulated by their C-Terminal Sequences.
R. Fairless, H. Masius, A. Rohlmann, K. Heupel, M. Ahmad, C. Reissner, T. Dresbach, and M. Missler (2008)
J. Neurosci. 28, 12969-12981
   Abstract »    Full Text »    PDF »
Molecular Substrates Mediating Lanthanide-Evoked Neurotransmitter Release in Central Synapses.
C. Chung, F. Deak, and E. T. Kavalali (2008)
J Neurophysiol 100, 2089-2100
   Abstract »    Full Text »    PDF »
Mutational analysis of the neurexin/neuroligin complex reveals essential and regulatory components.
C. Reissner, M. Klose, R. Fairless, and M. Missler (2008)
PNAS 105, 15124-15129
   Abstract »    Full Text »    PDF »
Developmental Control of Synaptic Receptivity.
A. J. Barker, S. M. Koch, J. Reed, B. A. Barres, and E. M. Ullian (2008)
J. Neurosci. 28, 8150-8160
   Abstract »    Full Text »    PDF »
Phenotype-Specific CpG Island Methylation Events in a Murine Model of Prostate Cancer.
M. Camoriano, S. R. Morey Kinney, M. T. Moser, B. A. Foster, J. L. Mohler, D. L. Trump, A. R. Karpf, and D. J. Smiraglia (2008)
Cancer Res. 68, 4173-4182
   Abstract »    Full Text »    PDF »
Significant association of the neurexin-1 gene (NRXN1) with nicotine dependence in European- and African-American smokers.
J. Nussbaum, Q. Xu, T. J. Payne, J. Z. Ma, W. Huang, J. Gelernter, and M. D. Li (2008)
Hum. Mol. Genet. 17, 1569-1577
   Abstract »    Full Text »    PDF »
Unusually rapid evolution of Neuroligin-4 in mice.
M. F. Bolliger, J. Pei, S. Maxeiner, A. A. Boucard, N. V. Grishin, and T. C. Sudhof (2008)
PNAS 105, 6421-6426
   Abstract »    Full Text »    PDF »
Induction of GABAergic Postsynaptic Differentiation by {alpha}-Neurexins.
Y. Kang, X. Zhang, F. Dobie, H. Wu, and A. M. Craig (2008)
J. Biol. Chem. 283, 2323-2334
   Abstract »    Full Text »    PDF »
Neurexin 3 polymorphisms are associated with alcohol dependence and altered expression of specific isoforms.
A. Hishimoto, Q.-R. Liu, T. Drgon, O. Pletnikova, D. Walther, X.-G. Zhu, J. C. Troncoso, and G. R. Uhl (2007)
Hum. Mol. Genet. 16, 2880-2891
   Abstract »    Full Text »    PDF »
SynCAMs Organize Synapses through Heterophilic Adhesion.
A. I. Fogel, M. R. Akins, A. J. Krupp, M. Stagi, V. Stein, and T. Biederer (2007)
J. Neurosci. 27, 12516-12530
   Abstract »    Full Text »    PDF »
A Neuroligin-3 Mutation Implicated in Autism Increases Inhibitory Synaptic Transmission in Mice.
K. Tabuchi, J. Blundell, M. R. Etherton, R. E. Hammer, X. Liu, C. M. Powell, and T. C. Sudhof (2007)
Science 318, 71-76
   Abstract »    Full Text »    PDF »
Silencing of Neuroligin Function by Postsynaptic Neurexins.
H. Taniguchi, L. Gollan, F. G. Scholl, V. Mahadomrongkul, E. Dobler, N. Limthong, M. Peck, C. Aoki, and P. Scheiffele (2007)
J. Neurosci. 27, 2815-2824
   Abstract »    Full Text »    PDF »
Comparative Genome Analysis of the Neurexin Gene Family in Danio rerio: Insights into Their Functions and Evolution.
A. Rissone, M. Monopoli, M. Beltrame, F. Bussolino, F. Cotelli, and M. Arese (2007)
Mol. Biol. Evol. 24, 236-252
   Abstract »    Full Text »    PDF »
Important Contribution of {alpha}-Neurexins to Ca2+-Triggered Exocytosis of Secretory Granules.
I. Dudanova, S. Sedej, M. Ahmad, H. Masius, V. Sargsyan, W. Zhang, D. Riedel, F. Angenstein, D. Schild, M. Rupnik, et al. (2006)
J. Neurosci. 26, 10599-10613
   Abstract »    Full Text »    PDF »
Solution structure of GOPC PDZ domain and its interaction with the C-terminal motif of neuroligin.
X. Li, J. Zhang, Z. Cao, J. Wu, and Y. Shi (2006)
Protein Sci. 15, 2149-2158
   Abstract »    Full Text »    PDF »
Crystal Structure of the Second LNS/LG Domain from Neurexin 1{alpha}: Ca2+ BINDING AND THE EFFECTS OF ALTERNATIVE SPLICING.
L. R. Sheckler, L. Henry, S. Sugita, T. C. Sudhof, and G. Rudenko (2006)
J. Biol. Chem. 281, 22896-22905
   Abstract »    Full Text »    PDF »
Novel splice isoforms for NLGN3 and NLGN4 with possible implications in autism..
Z Talebizadeh, D Y Lam, M F Theodoro, D C Bittel, G H Lushington, and M G Butler (2006)
J. Med. Genet. 43, e21
   Abstract »    Full Text »    PDF »
Structure function and splice site analysis of the synaptogenic activity of the neurexin-1beta LNS domain..
E. R. Graf, Y. Kang, A. M. Hauner, and A. M. Craig (2006)
J. Neurosci. 26, 4256-4265
   Abstract »    Full Text »    PDF »
N-Terminal Insertion and C-Terminal Ankyrin-Like Repeats of {alpha}-Latrotoxin Are Critical for Ca2+-Dependent Exocytosis.
G. Li, D. Lee, L. Wang, M. Khvotchev, S. K. Chiew, L. Arunachalam, T. Collins, Z.-P. Feng, and S. Sugita (2005)
J. Neurosci. 25, 10188-10197
   Abstract »    Full Text »    PDF »
Neurexophilin 3 Is Highly Localized in Cortical and Cerebellar Regions and Is Functionally Important for Sensorimotor Gating and Motor Coordination.
V. Beglopoulos, M. Montag-Sallaz, A. Rohlmann, K. Piechotta, M. Ahmad, D. Montag, and M. Missler (2005)
Mol. Cell. Biol. 25, 7278-7288
   Abstract »    Full Text »    PDF »
Dissection of Synapse Induction by Neuroligins: EFFECT OF A NEUROLIGIN MUTATION ASSOCIATED WITH AUTISM.
A. A. Chubykin, X. Liu, D. Comoletti, I. Tsigelny, P. Taylor, and T. C. Sudhof (2005)
J. Biol. Chem. 280, 22365-22374
   Abstract »    Full Text »    PDF »
Extracellular Domains of {alpha}-Neurexins Participate in Regulating Synaptic Transmission by Selectively Affecting N- and P/Q-Type Ca2+ Channels.
W. Zhang, A. Rohlmann, V. Sargsyan, G. Aramuni, R. E. Hammer, T. C. Sudhof, and M. Missler (2005)
J. Neurosci. 25, 4330-4342
   Abstract »    Full Text »    PDF »
Neuregulin induces the expression of transcription factors and myosin heavy chains typical of muscle spindles in cultured human muscle.
C. Jacobson, D. Duggan, and G. Fischbach (2004)
PNAS 101, 12218-12223
   Abstract »    Full Text »    PDF »
Dissection of Amyloid-{beta} Precursor Protein-dependent Transcriptional Transactivation.
X. Cao and T. C. Sudhof (2004)
J. Biol. Chem. 279, 24601-24611
   Abstract »    Full Text »    PDF »
Cleavage of Amyloid-{beta} Precursor Protein and Amyloid-{beta} Precursor-like Protein by BACE 1.
Q. Li and T. C. Sudhof (2004)
J. Biol. Chem. 279, 10542-10550
   Abstract »    Full Text »    PDF »
Postsynaptic N-methyl-D-aspartate receptor function requires {alpha}-neurexins.
G. Kattenstroth, E. Tantalaki, T. C. Sudhof, K. Gottmann, and M. Missler (2004)
PNAS 101, 2607-2612
   Abstract »    Full Text »    PDF »
Functional Excitatory Synapses in HEK293 Cells Expressing Neuroligin and Glutamate Receptors.
Z. Fu, P. Washbourne, P. Ortinski, and S. Vicini (2003)
J Neurophysiol 90, 3950-3957
   Abstract »    Full Text »    PDF »
A Neurexin-Related Protein, BAM-2, Terminates Axonal Branches in C. elegans.
A. Colavita and M. Tessier-Lavigne (2003)
Science 302, 293-296
   Abstract »    Full Text »    PDF »
Mutant {alpha}-Latrotoxin (LTXN4C) Does Not Form Pores and Causes Secretion by Receptor Stimulation: THIS ACTION DOES NOT REQUIRE NEUREXINS.
K. E. Volynski, M. Capogna, A. C. Ashton, D. Thomson, E. V. Orlova, C. F. Manser, R. R. Ribchester, and Y. A. Ushkaryov (2003)
J. Biol. Chem. 278, 31058-31066
   Abstract »    Full Text »    PDF »
Dystroglycan glycosylation and its role in matrix binding in skeletal muscle.
P. T. Martin (2003)
Glycobiology 13, 55R-66R
   Abstract »    Full Text »    PDF »
What's in the serum of seronegative MG and LEMS?.
M. Takamori, A. Abicht, H. Lochmuller, M. Motomura, Y. K. Nakao, T. Fukudome, T. Fukuda, H. Shiraishi, T. Yoshimura, M. Tsujihata, et al. (2003)
Neurology 61, 277-278
   Full Text »    PDF »
Gliotactin, a novel marker of tricellular junctions, is necessary for septate junction development in Drosophila.
J. Schulte, U. Tepass, and V. J. Auld (2003)
J. Cell Biol. 161, 991-1000
   Abstract »    Full Text »    PDF »
The {alpha}-Latrotoxin Mutant LTXN4C Enhances Spontaneous and Evoked Transmitter Release in CA3 Pyramidal Neurons.
M. Capogna, K. E. Volynski, N. J. Emptage, and Y. A. Ushkaryov (2003)
J. Neurosci. 23, 4044-4053
   Abstract »    Full Text »    PDF »
Post-translational Proteolytic Processing of the Calcium-independent Receptor of alpha -Latrotoxin (CIRL), a Natural Chimera of the Cell Adhesion Protein and the G Protein-coupled Receptor. ROLE OF THE G PROTEIN-COUPLED RECEPTOR PROTEOLYSIS SITE (GPS) MOTIF.
V. Krasnoperov, Y. Lu, L. Buryanovsky, T. A. Neubert, K. Ichtchenko, and A. G. Petrenko (2002)
J. Biol. Chem. 277, 46518-46526
   Abstract »    Full Text »    PDF »
Trachynilysin, a Neurosecretory Protein Isolated from Stonefish (Synanceia trachynis) Venom, Forms Nonselective Pores in the Membrane of NG108-15 Cells.
G. Ouanounou, M. Malo, J. Stinnakre, A. S. Kreger, and J. Molgo (2002)
J. Biol. Chem. 277, 39119-39127
   Abstract »    Full Text »    PDF »
Protein-tyrosine Phosphatase-sigma Is a Novel Member of the Functional Family of alpha -Latrotoxin Receptors.
V. Krasnoperov, M. A. Bittner, W. Mo, L. Buryanovsky, T. A. Neubert, R. W. Holz, K. Ichtchenko, and A. G. Petrenko (2002)
J. Biol. Chem. 277, 35887-35895
   Abstract »    Full Text »    PDF »
Regulation of APP-Dependent Transcription Complexes by Mint/X11s: Differential Functions of Mint Isoforms.
T. Biederer, X. Cao, T. C. Sudhof, and X. Liu (2002)
J. Neurosci. 22, 7340-7351
   Abstract »    Full Text »    PDF »
Genetic Analysis of alpha -Latrotoxin Receptors Reveals Functional Interdependence of CIRL/Latrophilin 1 and Neurexin 1alpha.
S. Tobaben, T. C. Sudhof, and B. Stahl (2002)
J. Biol. Chem. 277, 6359-6365
   Abstract »    Full Text »    PDF »
CASK and Protein 4.1 Support F-actin Nucleation on Neurexins.
T. Biederer and T. C. Sudhof (2001)
J. Biol. Chem. 276, 47869-47876
   Abstract »    Full Text »    PDF »
Stages of Synapse Development Defined by Dependence on F-Actin.
W. Zhang and D. L. Benson (2001)
J. Neurosci. 21, 5169-5181
   Abstract »    Full Text »    PDF »
A Transcriptively Active Complex of APP with Fe65 and Histone Acetyltransferase Tip60.
X. Cao and T. C. Sudhof (2001)
Science 293, 115-120
   Abstract »    Full Text »    PDF »
alpha -Latrotoxin Releases Calcium in Frog Motor Nerve Terminals.
C. W. Tsang, D. B. Elrick, and M. P. Charlton (2000)
J. Neurosci. 20, 8685-8692
   Abstract »    Full Text »    PDF »
Neurotoxins Affecting Neuroexocytosis.
G. Schiavo, M. Matteoli, and C. Montecucco (2000)
Physiol Rev 80, 717-766
   Abstract »    Full Text »    PDF »
Calcium-Independent Receptor for alpha -Latrotoxin and Neurexin H Facilitate Toxin-Induced Channel Formation: Evidence That Channel Formation Results from Tethering of Toxin to Membrane.
M. D. Hlubek, E. L. Stuenkel, V. G. Krasnoperov, A. G. Petrenko, and R. W. Holz (2000)
Mol. Pharmacol. 57, 519-528
   Abstract »    Full Text »
Trachynilysin mediates SNARE-dependent release of catecholamines from chromaffin cells via external and stored Ca2+.
F. Meunier, C Mattei, P Chameau, G Lawrence, C Colasante, A. Kreger, J. Dolly, and J Molgo (2000)
J. Cell Sci. 113, 1119-1125
   Abstract »    PDF »
Targeting of synaptotagmin to neurite terminals in neuronally differentiated PC12 cells.
P. Krasnov and G Enikolopov (2000)
J. Cell Sci. 113, 1389-1404
   Abstract »    PDF »
Regulated Expression and Subcellular Localization of Syndecan Heparan Sulfate Proteoglycans and the Syndecan-Binding Protein CASK/LIN-2 during Rat Brain Development.
Y.-P. Hsueh and M. Sheng (1999)
J. Neurosci. 19, 7415-7425
   Abstract »    Full Text »    PDF »
{alpha}-Latrotoxin Stimulates Inward Current, Rise in Cytosolic Calcium Concentration, and Exocytosis in at Pituitary Gonadotropes.
F. W. Tse and A. Tse (1999)
Endocrinology 140, 3025-3033
   Abstract »    Full Text »
The Subcellular Localizations of Atypical Synaptotagmins III and VI. SYNAPTOTAGMIN III IS ENRICHED IN SYNAPSES AND SYNAPTIC PLASMA MEMBRANES BUT NOT IN SYNAPTIC VESICLES.
S. Butz, R. Fernandez-Chacon, F. Schmitz, R. Jahn, and T. C. Sudhof (1999)
J. Biol. Chem. 274, 18290-18296
   Abstract »    Full Text »    PDF »
A Novel Ubiquitously Expressed alpha -Latrotoxin Receptor Is a Member of the CIRL Family of G-protein-coupled Receptors.
K. Ichtchenko, M. A. Bittner, V. Krasnoperov, A. R. Little, O. Chepurny, R. W. Holz, and A. G. Petrenko (1999)
J. Biol. Chem. 274, 5491-5498
   Abstract »    Full Text »    PDF »
Structural Requirements for alpha -Latrotoxin Binding and alpha -Latrotoxin-stimulated Secretion. A STUDY WITH CALCIUM-INDEPENDENT RECEPTOR OF alpha -LATROTOXIN (CIRL) DELETION MUTANTS.
V. Krasnoperov, M. A. Bittner, R. W. Holz, O. Chepurny, and A. G. Petrenko (1999)
J. Biol. Chem. 274, 3590-3596
   Abstract »    Full Text »    PDF »
Neuroligin 1 is a postsynaptic cell-adhesion molecule of excitatory synapses.
J.-Y. Song, K. Ichtchenko, T. C. Sudhof, and N. Brose (1999)
PNAS 96, 1100-1105
   Abstract »    Full Text »    PDF »
Neurexophilin Binding to alpha -Neurexins. A SINGLE LNS DOMAIN FUNCTIONS AS AN INDEPENDENTLY FOLDING LIGAND-BINDING UNIT.
M. Missler, R. E. Hammer, and T. C. Sudhof (1998)
J. Biol. Chem. 273, 34716-34723
   Abstract »    Full Text »    PDF »
alpha -Latrotoxin Receptor CIRL/Latrophilin 1 (CL1) Defines an Unusual Family of Ubiquitous G-protein-linked Receptors. G-PROTEIN COUPLING NOT REQUIRED FOR TRIGGERING EXOCYTOSIS.
S. Sugita, K. Ichtchenko, M. Khvotchev, and T. C. Sudhof (1998)
J. Biol. Chem. 273, 32715-32724
   Abstract »    Full Text »    PDF »
PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor.
B. Hock, B. Bohme, T. Karn, T. Yamamoto, K. Kaibuchi, U. Holtrich, S. Holland, T. Pawson, H. Rubsamen-Waigmann, and K. Strebhardt (1998)
PNAS 95, 9779-9784
   Abstract »    Full Text »    PDF »
alpha -Latrotoxin Alters Spontaneous and Depolarization-Evoked Quantal Release from Rat Adrenal Chromaffin Cells: Evidence for Multiple Modes of Action.
J. Liu and S. Misler (1998)
J. Neurosci. 18, 6113-6125
   Abstract »    Full Text »    PDF »
Direct Interaction of CASK/LIN-2 and Syndecan Heparan Sulfate Proteoglycan and Their Overlapping Distribution in Neuronal Synapses.
Y.-P. Hsueh, F.-C. Yang, V. Kharazia, S. Naisbitt, A. R. Cohen, R. J. Weinberg, and M. Sheng (1998)
J. Cell Biol. 142, 139-151
   Abstract »    Full Text »    PDF »
Neurexophilins Form a Conserved Family of Neuropeptide-Like Glycoproteins.
M. Missler and T. C. Sudhof (1998)
J. Neurosci. 18, 3630-3638
   Abstract »    Full Text »    PDF »
A Ca2+-Independent Receptor for alpha -Latrotoxin, CIRL, Mediates Effects on Secretion via Multiple Mechanisms.
M. A. Bittner, V. G. Krasnoperov, E. L. Stuenkel, A. G. Petrenko, and R. W. Holz (1998)
J. Neurosci. 18, 2914-2922
   Abstract »    Full Text »    PDF »
Visualization of the Dynamics of Synaptic Vesicle and Plasma Membrane Proteins in Living Axons.
T. Nakata, S. Terada, and N. Hirokawa (1998)
J. Cell Biol. 140, 659-674
   Abstract »    Full Text »    PDF »
Neurexin Ialpha Is a Major alpha -Latrotoxin Receptor That Cooperates in alpha -Latrotoxin Action.
M. Geppert, M. Khvotchev, V. Krasnoperov, Y. Goda, M. Missler, R. E. Hammer, K. Ichtchenko, A. G. Petrenko, and T. C. Sudhof (1998)
J. Biol. Chem. 273, 1705-1710
   Abstract »    Full Text »    PDF »
The Axonal Membrane Protein Caspr, a Homologue of Neurexin IV, Is a Component of the Septate-like Paranodal Junctions That Assemble during Myelination.
S. Einheber, G. Zanazzi, W. Ching, S. Scherer, T. A. Milner, E. Peles, and J. L. Salzer (1997)
J. Cell Biol. 139, 1495-1506
   Abstract »    Full Text »    PDF »
Primary Structure, Developmental Expression, and Immunolocalization of the Murine Laminin alpha 4 Chain.
A. Iivanainen, J. Kortesmaa, C. Sahlberg, T. Morita, U. Bergmann, I. Thesleff, and K. Tryggvason (1997)
J. Biol. Chem. 272, 27862-27868
   Abstract »    Full Text »    PDF »
Binding Properties of Neuroligin 1 and Neurexin 1beta Reveal Function as Heterophilic Cell Adhesion Molecules.
T. Nguyen and T. C. Sudhof (1997)
J. Biol. Chem. 272, 26032-26039
   Abstract »    Full Text »    PDF »
alpha -Latrotoxin Receptor, Latrophilin, Is a Novel Member of the Secretin Family of G Protein-coupled Receptors.
V. G. Lelianova, B. A. Davletov, A. Sterling, M. A. Rahman, E. V. Grishin, N. F. Totty, and Y. A. Ushkaryov (1997)
J. Biol. Chem. 272, 21504-21508
   Abstract »    Full Text »    PDF »
Afferent Innervation Influences the Development of Dendritic Branches and Spines via Both Activity-Dependent and Non-Activity-Dependent Mechanisms.
A. H. Kossel, C. V. Williams, M. Schweizer, and S. B. Kater (1997)
J. Neurosci. 17, 6314-6324
   Abstract »    Full Text »    PDF »
Acetylcholinesterase-transgenic mice display embryonic modulations in spinal cord choline acetyltransferase and neurexin Ibeta gene expression followed by late-onset neuromotor deterioration.
C. Andres, R. Beeri, A. Friedman, E. Lev-Lehman, S. Henis, R. Timberg, M. Shani, and H. Soreq (1997)
PNAS 94, 8173-8178
   Abstract »    Full Text »    PDF »
Neurexin Is Expressed on Nerves, But Not at Nerve Terminals, in the Electric Organ.
A. B. Russell and S. S. Carlson (1997)
J. Neurosci. 17, 4734-4743
   Abstract »    Full Text »    PDF »
Deciphering the Function of Neurexins at Cellular Junctions.
J. T. Littleton, M. A. Bhat, and H. J. Bellen (1997)
J. Cell Biol. 137, 793-796
   Full Text »    PDF »
Physical and Functional Interaction of Rabphilin-3A with alpha -Actinin.
M. Kato, T. Sasaki, T. Ohya, H. Nakanishi, H. Nishioka, M. Imamura, and Y. Takai (1996)
J. Biol. Chem. 271, 31775-31778
   Abstract »    Full Text »    PDF »
Isolation and Biochemical Characterization of a Ca2+-independent alpha -Latrotoxin-binding Protein.
B. A. Davletov, O. G. Shamotienko, V. G. Lelianova, E. V. Grishin, and Y. A. Ushkaryov (1996)
J. Biol. Chem. 271, 23239-23245
   Abstract »    Full Text »    PDF »
Structure and Evolution of Neurexophilin.
A. G. Petrenko, B. Ullrich, M. Missler, V. Krasnoperov, T. W. Rosahl, and T. C. Sudhof (1996)
J. Neurosci. 16, 4360-4369
   Abstract »    Full Text »    PDF »
Cloning and Structure of [IMAGE]-Latroinsectotoxin, a Novel Insect-specific Member of the Latrotoxin Family.
I. E. Dulubova, V. G. Krasnoperov, M. V. Khvotchev, K. A. Pluzhnikov, T. M. Volkova, E. V. Grishin, H. Vais, D. R. Bell, and P. N. R. Usherwood (1996)
J. Biol. Chem. 271, 7535-7543
   Abstract »    Full Text »    PDF »
Structures, Alternative Splicing, and Neurexin Binding of Multiple Neuroligins.
K. Ichtchenko, T. Nguyen, and T. C. Südhof (1996)
J. Biol. Chem. 271, 2676-2682
   Abstract »    Full Text »    PDF »
High Affinity Binding of alpha-Latrotoxin to Recombinant Neurexin Ialpha.
B. A. Davletov, V. Krasnoperov, Y. Hata, A. G. Petrenko, and T. C. Südhof (1995)
J. Biol. Chem. 270, 23903-23905
   Abstract »    Full Text »    PDF »
A Novel Ubiquitous Form of Munc-18 Interacts with Multiple Syntaxins.
Y. Hata and T. C. Südhof (1995)
J. Biol. Chem. 270, 13022-13028
   Abstract »    Full Text »    PDF »
Recombinant Domain III of Perlecan Promotes Cell Attachment through Its RGDS Sequence.
S. Chakravarti, T. Horchar, B. Jefferson, G. W. Laurie, and J. R. Hassell (1995)
J. Biol. Chem. 270, 404-409
   Abstract »    Full Text »    PDF »
Expression of synaptotagmin in Drosophila reveals transport and localization of synaptic vesicles to the synapse.
J. Littleton, H. Bellen, and M. Perin (1993)
Development 118, 1077-1088
   Abstract »    PDF »
A stoichiometric complex of neurexins and dystroglycan in brain.
S. Sugita, F. Saito, J. Tang, J. Satz, K. Campbell, and T. C. Sudhof (2001)
J. Cell Biol. 154, 435-446
   Abstract »    Full Text »    PDF »
Mints as Adaptors. DIRECT BINDING TO NEUREXINS AND RECRUITMENT OF Munc18.
T. Biederer and T. C. Sudhof (2000)
J. Biol. Chem. 275, 39803-39806
   Abstract »    Full Text »    PDF »
Latrotoxin Stimulates Secretion in Permeabilized Cells by Regulating an Intracellular Ca2+- and ATP-dependent Event. A ROLE FOR PROTEIN KINASE C.
M. A. Bittner and R. W. Holz (2000)
J. Biol. Chem. 275, 25351-25357
   Abstract »    Full Text »    PDF »
Latrophilin, Neurexin, and Their Signaling-deficient Mutants Facilitate alpha -Latrotoxin Insertion into Membranes but Are Not Involved in Pore Formation.
K. E. Volynski, F. A. Meunier, V. G. Lelianova, E. E. Dudina, T. M. Volkova, M. A. Rahman, C. Manser, E. V. Grishin, J. O. Dolly, R. H. Ashley, et al. (2000)
J. Biol. Chem. 275, 41175-41183
   Abstract »    Full Text »    PDF »
The G Protein-coupled Receptor CL1 Interacts Directly with Proteins of the Shank Family.
S. Tobaben, T. C. Sudhof, and B. Stahl (2000)
J. Biol. Chem. 275, 36204-36210
   Abstract »    Full Text »    PDF »
alpha -Latrotoxin, Acting via Two Ca2+-dependent Pathways, Triggers Exocytosis of Two Pools of Synaptic Vesicles.
A. C. Ashton, K. E. Volynski, V. G. Lelianova, E. V. Orlova, C. Van Renterghem, M. Canepari, M. Seagar, and Y. A. Ushkaryov (2001)
J. Biol. Chem. 276, 44695-44703
   Abstract »    Full Text »    PDF »



ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products


Science. ISSN 0036-8075 (print), 1095-9203 (online)

AAAS Logo HWP Logo

Magazine  |  News  |  Signaling  |  Careers  |  Multimedia  |  Collections  |  Help  |  Site Map  |  RSS

Subscribe  |  Feedback  |  Privacy / Legal  |