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Science 3 July 1992:
Vol. 257. no. 5066, pp. 91 - 94
DOI: 10.1126/science.1320290
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Articles

Science, Vol 257, Issue 5066, 91-94
Copyright © 1992 by American Association for the Advancement of Science

articles

Expression of a ryanodine receptor-Ca2+ channel that is regulated by TGF-beta

G Giannini, E Clementi, R Ceci, G Marziali, and V Sorrentino

European Molecular Biology Laboratory, Heidelberg, Germany.

Ryanodine receptors (RyRs) are intracellular channels that release calcium ions from the sarcoplasmic reticulum (SR) in response to either plasma membrane depolarization (in skeletal muscle) or increases in the concentration of intracellular free Ca2+ (in the heart). A gene (beta 4) encoding a ryanodine receptor (similar to, but distinct from, the muscle RyRs) was identified. The beta 4 gene was expressed in all tissues investigated, with the exception of heart. Treatment of mink lung epithelial cells (Mv1Lu) with transforming growth factor beta (TGF-beta) induced expression of the beta 4 gene together with the release of Ca2+ in response to ryanodine (but not in response to caffeine, the other drug active on muscle RyRs). This ryanodine receptor may be important in the regulation of intracellular Ca2+ homeostasis.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)