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Science 10 July 1992:
Vol. 257. no. 5067, pp. 206 - 211
DOI: 10.1126/science.1321493
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Articles

Science, Vol 257, Issue 5067, 206-211
Copyright © 1992 by American Association for the Advancement of Science

articles

Impaired spatial learning in alpha-calcium-calmodulin kinase II mutant mice

AJ Silva, R Paylor, JM Wehner, and S Tonegawa

Howard Hughes Medical Institute, Center for Cancer Research, Cambridge, MA.

Although long-term potentiation (LTP) has been studied as the mechanism for hippocampus-dependent learning and memory, evidence for this hypothesis is still incomplete. The mice with a mutation in the alpha-calcium-calmodulin-dependent kinase II (alpha-CaMKII), a synaptic protein enriched in the hippocampus, are appropriate for addressing this issue because the hippocampus of these mice is deficient in LTP but maintains intact postsynaptic mechanisms. These mutant mice exhibit specific learning impairments, an indication that alpha-CaMKII has a prominent role in spatial learning, but that it is not essential for some types of non-spatial learning. The data considerably strengthen the contention that the synaptic changes exhibited in LTP are the basis for spatial memory.


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Phosphorylation of the alpha -Amino-3-hydroxy-5-methylisoxazole4-propionic Acid Receptor GluR1 Subunit by Calcium/ Calmodulin-dependent Kinase II.
A. L. Mammen, K. Kameyama, K. W. Roche, and R. L. Huganir (1997)
J. Biol. Chem. 272, 32528-32533
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Phosphorylation-dependent Reversible Association of Ca2+/Calmodulin-dependent Protein Kinase II with the Postsynaptic Densities.
Y. Yoshimura and T. Yamauchi (1997)
J. Biol. Chem. 272, 26354-26359
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Secondary Structure and Ca2+-induced Conformational Change of Calexcitin, a Learning-associated Protein.
G. A. Ascoli, K. X. Luu, J. L. Olds, T. J. Nelson, P. A. Gusev, C. Bertucci, E. Bramanti, A. Raffaelli, P. Salvadori, and D. L. Alkon (1997)
J. Biol. Chem. 272, 24771-24779
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Visualization of the Distribution of Autophosphorylated Calcium/Calmodulin-Dependent Protein Kinase II after Tetanic Stimulation in the CA1 Area of the Hippocampus.
Y. Ouyang, D. Kantor, K. M. Harris, E. M. Schuman, and M. B. Kennedy (1997)
J. Neurosci. 17, 5416-5427
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Reversible antisense inhibition of Shaker-like Kv1.1 potassium channel expression impairs associative memory in mouse and rat.
N. Meiri, C. Ghelardini, G. Tesco, N. Galeotti, D. Dahl, D. Tomsic, S. Cavallaro, A. Quattrone, S. Capaccioli, A. Bartolini, et al. (1997)
PNAS 94, 4430-4434
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