Science 10 July 1992: Vol. 257. no. 5067, pp. 212 - 214 DOI: 10.1126/science.1378649

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Articles

Oncogene addiction: setting the stage for molecularly targeted cancer therapy.

S. V. Sharma and J. Settleman (2007)
Genes & Dev. 21, 3214-3231
 |  Abstract »  |  Full Text »  |  PDF »

Inflammatory disease and lymphomagenesis caused by deletion of the myc antagonist mnt in T cells..

S. Dezfouli, A. Bakke, J. Huang, A. Wynshaw-Boris, and P. J. Hurlin (2006)
Mol. Cell. Biol. 26, 2080-2092
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A Role for p38 Mitogen-Activated Protein Kinase and c-Myc in Endothelin-Dependent Rat Aortic Smooth Muscle Cell Proliferation.

S. Chen, Y. Qiong, and D. G. Gardner (2006)
Hypertension 47, 252-258
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Identification and Characterization of Survival-Related Gene, a Novel Cell Survival Gene Controlling Apoptosis and Tumorigenesis.

Z.-R. Yuan, R. Wang, J. Solomon, X. Luo, H. Sun, L. Zhang, and Y. Shi (2005)
Cancer Res. 65, 10716-10724
 |  Abstract »  |  Full Text »  |  PDF »

Egr-1 abrogates the block imparted by c-Myc on terminal M1 myeloid differentiation.

M. Shafarenko, D. A. Liebermann, and B. Hoffman (2005)
Blood 106, 871-878
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Antiapoptotic Microenvironment of Acute Myeloid Leukemia.

D. Milojkovic, S. Devereux, N. B. Westwood, G. J. Mufti, N. S. B. Thomas, and A. G. S. Buggins (2004)
J. Immunol. 173, 6745-6752
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Identification of novel Myc target genes with a potential role in lymphomagenesis.

D. Marinkovic, T. Marinkovic, E. Kokai, T. Barth, P. Moller, and T. Wirth (2004)
Nucleic Acids Res. 32, 5368-5378
 |  Abstract »  |  Full Text »  |  PDF »

c-Fos Is a Mediator of the c-Myc-induced Apoptotic Signaling in Serum-deprived Hepatoma Cells via the p38 Mitogen-activated Protein Kinase Pathway.

N. Kalra and V. Kumar (2004)
J. Biol. Chem. 279, 25313-25319
 |  Abstract »  |  Full Text »  |  PDF »

Loss of MYC Confers Resistance to Doxorubicin-induced Apoptosis by Preventing the Activation of Multiple Serine Protease- and Caspase-mediated Pathways.

E. Grassilli, A. Ballabeni, E. Maellaro, B. Del Bello, and K. Helin (2004)
J. Biol. Chem. 279, 21318-21326
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Significance of c-Myc and Bcl-2 Protein Expression in Nasopharyngeal Carcinoma.

Y. Yu, W. Dong, X. Li, E. Yu, X. Zhou, and S. Li (2003)
Arch Otolaryngol Head Neck Surg 129, 1322-1326
 |  Abstract »  |  Full Text »  |  PDF »

NF{kappa}B Controls the Balance between Fas and Tumor Necrosis Factor Cell Death Pathways during T Cell Receptor-induced Apoptosis Via the Expression of Its Target Gene A20.

M. Malewicz, N. Zeller, Z. B. Yilmaz, and F. Weih (2003)
J. Biol. Chem. 278, 32825-32833
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Peroxisome Proliferator-Activated Receptor {gamma}-Mediated NF-{kappa}B Activation and Apoptosis in Pre-B Cells.

J. J. Schlezinger, B. A. Jensen, K. K. Mann, H.-Y. Ryu, and D. H. Sherr (2002)
J. Immunol. 169, 6831-6841
 |  Abstract »  |  Full Text »  |  PDF »

Cyclin D3 activates Caspase 2, connecting cell proliferation with cell death.

A. R. Mendelsohn, J. D. Hamer, Z. B. Wang, and R. Brent (2002)
PNAS 99, 6871-6876
 |  Abstract »  |  Full Text »  |  PDF »

I-{kappa}B Kinases {alpha} and {beta} Have Distinct Roles in Regulating Murine T Cell Function.

H. Ren, A. Schmalstieg, N. S. C. van Oers, and R. B. Gaynor (2002)
J. Immunol. 168, 3721-3731
 |  Abstract »  |  Full Text »  |  PDF »

Escherichia coli Enterotoxin B Subunit Triggers Apoptosis of CD8+ T Cells by Activating Transcription Factor c-Myc.

M. Soriani, N. A. Williams, and T. R. Hirst (2001)
Infect. Immun. 69, 4923-4930
 |  Abstract »  |  Full Text »  |  PDF »

c-Myc Is Necessary for DNA Damage-Induced Apoptosis in the G2 Phase of the Cell Cycle.

S. Adachi, A. J. Obaya, Z. Han, N. Ramos-Desimone, J. H. Wyche, and J. M. Sedivy (2001)
Mol. Cell. Biol. 21, 4929-4937
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Myc Potentiates Apoptosis by Stimulating Bax Activity at the Mitochondria.

E. L. Soucie, M. G. Annis, J. Sedivy, J. Filmus, B. Leber, D. W. Andrews, and L. Z. Penn (2001)
Mol. Cell. Biol. 21, 4725-4736
 |  Abstract »  |  Full Text »  |  PDF »

Identification of human DNA helicase V with the far upstream element-binding protein.

A. Vindigni, A. Ochem, G. Triolo, and A. Falaschi (2001)
Nucleic Acids Res. 29, 1061-1067
 |  Abstract »  |  Full Text »  |  PDF »

Targeted Deletion of the S-Phase-Specific Myc Antagonist Mad3 Sensitizes Neuronal and Lymphoid Cells to Radiation-Induced Apoptosis.

C. Quéva, G. A. McArthur, B. M. Iritani, and R. N. Eisenman (2001)
Mol. Cell. Biol. 21, 703-712
 |  Abstract »  |  Full Text »

Vasoactive Intestinal Peptide and Pituitary Adenylate Cyclase-Activating Polypeptide Inhibit Expression of Fas Ligand in Activated T Lymphocytes by Regulating c-Myc, NF-{{kappa}}B, NF-AT, and Early Growth Factors 2/3.

M. Delgado and D. Ganea (2001)
J. Immunol. 166, 1028-1040
 |  Abstract »  |  Full Text »  |  PDF »

Antisense delivery using protamine-oligonucleotide particles.

M. Junghans, J. Kreuter, and A. Zimmer (2000)
Nucleic Acids Res. 28, e45
 |  Abstract »  |  Full Text »  |  PDF »

An in Vivo Function for the Transforming Myc Protein: Elicitation of the Angiogenic Phenotype.

C. V. Ngo, M. Gee, N. Akhtar, D. Yu, O. Volpert, R. Auerbach, and A. Thomas-Tikhonenko (2000)
Cell Growth Differ. 11, 201-210
 |  Abstract »  |  Full Text »

Expression of Fas Ligand in Activated T Cells Is Regulated by c-Myc.

T. Brunner, S. Kasibhatla, M. J. Pinkoski, C. Frutschi, N. J. Yoo, F. Echeverri, A. Mahboubi, and D. R. Green (2000)
J. Biol. Chem. 275, 9767-9772
 |  Abstract »  |  Full Text »  |  PDF »

Heme oxygenase-1 inhibits TNF-alpha -induced apoptosis in cultured fibroblasts.

I. Petrache, L. E. Otterbein, J. Alam, G. W. Wiegand, and A. M. K. Choi (2000)
Am J Physiol Lung Cell Mol Physiol 278, L312-L319
 |  Abstract »  |  Full Text »  |  PDF »

Protein Kinase C{theta} Cooperates with Calcineurin to Induce Fas Ligand Expression During Activation-Induced T Cell Death.

M. Villalba, S. Kasibhatla, L. Genestier, A. Mahboubi, D. R. Green, and A. Altman (1999)
J. Immunol. 163, 5813-5819
 |  Abstract »  |  Full Text »  |  PDF »

p53 Inhibits {alpha}6{beta}4 Integrin Survival Signaling by Promoting the Caspase 3-dependent Cleavage of AKT/PKB.

R. E. Bachelder, M. J. Ribick, A. Marchetti, R. Falcioni, S. Soddu, K. R. Davis, and A. M. Mercurio (1999)
J. Cell Biol. 147, 1063-1072
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Regulation of c-Myc through Phosphorylation at Ser-62 and Ser-71 by c-Jun N-Terminal Kinase.

K. Noguchi, C. Kitanaka, H. Yamana, A. Kokubu, T. Mochizuki, and Y. Kuchino (1999)
J. Biol. Chem. 274, 32580-32587
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Apoptosis in Proliferating, Senescent, and Immortalized Keratinocytes.

V. Chaturvedi, J.-Z. Qin, M. F. Denning, D. Choubey, M. O. Diaz, and B. J. Nickoloff (1999)
J. Biol. Chem. 274, 23358-23367
 |  Abstract »  |  Full Text »  |  PDF »

Mitogen-Activated Protein Kinase Kinase Kinase 1 Activates Androgen Receptor-Dependent Transcription and Apoptosis in Prostate Cancer.

M. T. Abreu-Martin, A. Chari, A. A. Palladino, N. A. Craft, and C. L. Sawyers (1999)
Mol. Cell. Biol. 19, 5143-5154
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Pharmacology of the Eosinophil.

M. A. Giembycz and M. A. Lindsay (1999)
Pharmacol. Rev. 51, 213-340
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Expression of the c-myc Proto-oncogene Is Essential for HIV-1 Infection in Activated T Cells.

Y. Sun and E. A. Clark (1999)
J. Exp. Med. 189, 1391-1398
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin-2 Overexpresses c-myc and Down-Regulates Cytochrome P-450 in Rat Hepatocytes.

M. Tinel, J. Elkahwaji, M. A. Robin, N. Fardel, V. Descatoire, D. Haouzi, A. Berson, and D. Pessayre (1999)
J. Pharmacol. Exp. Ther. 289, 649-655
 |  Abstract »  |  Full Text »

Death Receptor Fas/Apo-1/CD95 Expressed by Human Placental Cytotrophoblasts Does Not Mediate Apoptosis.

S. G. Payne, S. C. Smith, S. T. Davidge, P. N. Baker, and L. J. Guilbert (1999)
Biol Reprod 60, 1144-1150
 |  Abstract »  |  Full Text »

Functional Domains of c-myc Promoter Binding Protein 1 Involved in Transcriptional Repression and Cell Growth Regulation.

A. K. Ghosh, R. Steele, and R. B. Ray (1999)
Mol. Cell. Biol. 19, 2880-2886
 |  Abstract »  |  Full Text »  |  PDF »

Transforming Growth Factor beta 1 Inhibits Fas Ligand Expression and Subsequent Activation-induced Cell Death in T Cells via Downregulation of c-Myc.

L. Genestier, S. Kasibhatla, T. Brunner, and D. R. Green (1999)
J. Exp. Med. 189, 231-239
 |  Abstract »  |  Full Text »  |  PDF »

A Role for Perforin in Activation-Induced T Cell Death In Vivo: Increased Expansion of Allogeneic Perforin-Deficient T Cells in SCID mice.

D. Spaner, K. Raju, B. Rabinovich, and R. G. Miller (1999)
J. Immunol. 162, 1192-1199
 |  Abstract »  |  Full Text »  |  PDF »

Accelerated Neutrophil Apoptosis in Mice Lacking A1-a, a Subtype of the bcl-2-related A1 Gene.

A. Hamasaki, F. Sendo, K. Nakayama, N. Ishida, I. Negishi, K.-i. Nakayama, and S. Hatakeyama (1998)
J. Exp. Med. 188, 1985-1992
 |  Abstract »  |  Full Text »  |  PDF »

Adenovirus-Mediated Expression of a Dominant Negative Mutant of p65/RelA Inhibits Proinflammatory Gene Expression in Endothelial Cells Without Sensitizing to Apoptosis.

M. P. Soares, A. Muniappan, E. Kaczmarek, K. Koziak, C. J. Wrighton, F. Steinhauslin, C. Ferran, H. Winkler, F. H. Bach, and J. Anrather (1998)
J. Immunol. 161, 4572-4582
 |  Abstract »  |  Full Text »  |  PDF »

A Matter of Life and Cell Death.

G. Evan and T. Littlewood (1998)
Science 281, 1317-1322
 |  Abstract »  |  Full Text »

The molecular role of Myc in growth and transformation: recent discoveries lead to new insights.

L. Facchini and L. Z. Penn (1998)
FASEB J 12, 633-651
 |  Abstract »  |  Full Text »

Antisense TR3 Orphan Receptor Can Increase Prostate Cancer Cell Viability with Etoposide Treatment.

H. Uemura and C. Chang (1998)
Endocrinology 139, 2329-2334
 |  Abstract »  |  Full Text »  |  PDF »

cAMP increasing agents attenuate the generation of apoptosis by etoposide in promonocytic leukemia cells.

L Garcia-Bermejo, C Perez, N. Vilaboa, E de Blas, and P Aller (1998)
J. Cell Sci. 111, 637-644
 |  Abstract »  |  PDF »

Requirement for the CD95 Receptor-Ligand Pathway in c-Myc-Induced Apoptosis.

A. Hueber, M. Zörnig, D. Lyon, T. Suda, S. Nagata, and G. I. Evan (1997)
Science 278, 1305-1309
 |  Abstract »  |  Full Text »

Fcgamma RIII-Mediated Regulation of Hematopoiesis in Murine Bone Marrow Cells by Interleukin-3 and CD95 (Fas/Apo-1).

H. Yoshikawa, T. Sakihama, Y. Nakajima, and K. Tasaka (1997)
Blood 90, 1911-1919
 |  Abstract »  |  Full Text »  |  PDF »

Fas- or Ceramide-induced Apoptosis Is Mediated by a Rac1-regulated Activation of Jun N-terminal Kinase/p38 Kinases and GADD153.

B. Brenner, U. Koppenhoefer, C. Weinstock, O. Linderkamp, F. Lang, and E. Gulbins (1997)
J. Biol. Chem. 272, 22173-22181
 |  Abstract »  |  Full Text »  |  PDF »

Distinct Roles for MAX Protein Isoforms in Proliferation and Apoptosis.

H. Zhang, S. Fan, and E. V. Prochownik (1997)
J. Biol. Chem. 272, 17416-17424
 |  Abstract »  |  Full Text »  |  PDF »

Proteasome regulation of activation-induced T cell death.

H. Cui, K. Matsui, S. Omura, S. L. Schauer, R. A. Matulka, G. E. Sonenshein, and S.-T. Ju (1997)
PNAS 94, 7515-7520
 |  Abstract »  |  Full Text »  |  PDF »

Transcription Factor Activation during Signal-induced Apoptosis of Immature CD4+CD8+ Thymocytes. A PROTECTIVE ROLE OF c-Fos.

V. N. Ivanov and V. N. Ivanov (1997)
J. Biol. Chem. 272, 8558-8566
 |  Abstract »  |  Full Text »  |  PDF »

Glucose deprivation-induced cytotoxicity in drug resistant human breast carcinoma MCF-7/ADR cells: role of c-myc and bcl-2 in apoptotic cell death.

Y. Lee, S. Galoforo, C. Berns, W. Tong, H. Kim, and P. Corry (1997)
J. Cell Sci. 110, 681-686
 |  Abstract »  |  PDF »

Down-regulation of actin genes precedes microfilament network disruption and actin cleavage during p53-mediated apoptosis.

I Guenal, Y Risler, and B Mignotte (1997)
J. Cell Sci. 110, 489-495
 |  Abstract »  |  PDF »

Signal transduction pathways in apoptosis.

D. McConkey and S Orrenius (1996)
Stem Cells 14, 619-631
 |  Abstract »

Regulation of T cell apoptosis via T cell receptors and steroid receptors.

M Iwata, Y Ohoka, T Kuwata, and A Asada (1996)
Stem Cells 14, 632-641
 |  Abstract »

Hydroquinone, a bioreactive metabolite of benzene, inhibits apoptosis in myeloblasts.

B. Hazel, C Baum, and G. Kalf (1996)
Stem Cells 14, 730-742
 |  Abstract »

Fas-induced Apoptosis Is Mediated by Activation of a Ras and Rac Protein-regulated Signaling Pathway.

E. Gulbins, K.M. Coggeshall, B. Brenner, K. Schlottmann, O. Linderkamp, and F. Lang (1996)
J. Biol. Chem. 271, 26389-26394
 |  Abstract »  |  Full Text »  |  PDF »

Follicular Atresia as an Apoptotic Process: Atresia-Associated Increase in the Ovarian Expression of the Putative Apoptotic Marker Sulfated Glycoprotein-2.

A. Hurwitz, K. Ruutiainen-Altman, L. Marzella, L. Botero, M. Dushnik, and E. Y. Adashi (1996)
Reproductive Sciences 3, 199-208
 |  Abstract »  |  PDF »

Fibroblast Growth Factor-2 Suppression of Tumor Necrosis Factor alpha -Mediated Apoptosis Requires Ras and the Activation of Mitogen-activated Protein Kinase.

A. M. Gardner and G. L. Johnson (1996)
J. Biol. Chem. 271, 14560-14566
 |  Abstract »  |  Full Text »  |  PDF »

Suppression of Apoptosis by Dominant Negative Mutants of Cyclin-dependent Protein Kinases.

W. Meikrantz and R. Schlegel (1996)
J. Biol. Chem. 271, 10205-10209
 |  Abstract »  |  Full Text »  |  PDF »

Signal Transduction Pathways Regulated by Mitogen-activated/Extracellular Response Kinase Kinase Kinase Induce Cell Death.

N. L. Johnson, A. M. Gardner, K. M. Diener, C. A. Lange-Carter, J. Gleavy, M. B. Jarpe, A. Minden, M. Karin, L. I. Zon, and G. L. Johnson (1996)
J. Biol. Chem. 271, 3229-3237
 |  Abstract »  |  Full Text »  |  PDF »

Induction of Apoptosis by the c-Myc Helix-Loop-Helix/Leucine Zipper Domain in Mouse 3T3-L1 Fibroblasts.

F. Kohlhuber, H. Hermeking, A. Graessmann, and D. Eick (1995)
J. Biol. Chem. 270, 28797-28805
 |  Abstract »  |  Full Text »  |  PDF »

Growth Inhibition of Hepatoma Cells Induced by Vitamin K and Its Analogs.

Y. Nishikawa, B. I. Carr, M. Wang, S. Kar, F. Finn, P. Dowd, Z. B. Zheng, J. Kerns, and S. Naganathan (1995)
J. Biol. Chem. 270, 28304-28310
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of the Fas Apoptotic Cell Death Pathway by Abl.

A. J. McGahon, W. K. Nishioka, S. J. Martin, A. Mahboubi, T. G. Cotter, and D. R. Green (1995)
J. Biol. Chem. 270, 22625-22631
 |  Abstract »  |  Full Text »  |  PDF »

Neurotrophic Factor Protection against Excitotoxic Neuronal Death.

S. B. Tatter, W. R. Galpern, and O. Isacson (1995)
Neuroscientist 1, 286-297
 |  Abstract »  |  PDF »

Unimpaired thymic and peripheral T cell death in mice lacking the nuclear receptor NGFI-B (Nur77).

S. Lee, R. Wesselschmidt, G. Linette, O Kanagawa, J. Russell, and J Milbrandt (1995)
Science 269, 532-535
 |  Abstract »  |  PDF »

Proteolysis of Fodrin (Non-erythroid Spectrin) during Apoptosis.

S. J. Martin, G. A. O'Brien, W. K. Nishioka, A. J. McGahon, A. Mahboubi, T. C. Saido, and D. R. Green (1995)
J. Biol. Chem. 270, 6425-6428
 |  Abstract »  |  Full Text »  |  PDF »

Cell cycle control and cancer.

L. Hartwell and M. Kastan (1994)
Science 266, 1821-1828
 |  Abstract »  |  PDF »

Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1..

A J Wagner, J M Kokontis, and N Hay (1994)
Genes & Dev. 8, 2817-2830
 |  Abstract »  |  PDF »

Mediation of c-Myc-induced apoptosis by p53.

H Hermeking and D Eick (1994)
Science 265, 2091-2093
 |  Abstract »  |  PDF »

Binding and suppression of the Myc transcriptional activation domain by p107.

W Gu, K Bhatia, I. Magrath, C. Dang, and R Dalla-Favera (1994)
Science 264, 251-254
 |  Abstract »  |  PDF »

A sequence-specific, single-strand binding protein activates the far upstream element of c-myc and defines a new DNA-binding motif..

R Duncan, L Bazar, G Michelotti, T Tomonaga, H Krutzsch, M Avigan, and D Levens (1994)
Genes & Dev. 8, 465-480
 |  Abstract »  |  PDF »

The Genetics of Programmed Cell Death in the Nematode Caenorhabditis elegans.

H.R. Horvitz, S. Shaham, and M.O. Hengartner (1994)
Cold Spring Harb Symp Quant Biol 59, 377-385
 |  Abstract »  |  PDF »

Death-defying acts: a meeting review on apoptosis..

E White (1993)
Genes & Dev. 7, 2277-2284
 |  PDF »

Antisense oligonucleotides as therapeutic agents--is the bullet really magical?.

C. Stein and Y. Cheng (1993)
Science 261, 1004-1012
 |  Abstract »  |  PDF »

The control of chondrocyte differentiation during endochondral bone growth in vivo: changes in TGF-beta and the proto-oncogene c-myc.

N Loveridge, C Farquharson, J. Hesketh, S. Jakowlew, C. Whitehead, and B. Thorp (1993)
J. Cell Sci. 105, 949-956
 |  Abstract »  |  PDF »

The Heparin-binding Domain and V Region of Fibronectin Regulate Apoptosis by Suppression of p53 and c-myc in Human Primary Cells.

Y. L. Kapila, S. Wang, P. Dazin, E. Tafolla, and M. J. Mass (2002)
J. Biol. Chem. 277, 8482-8491
 |  Abstract »  |  Full Text »  |  PDF »

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