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Science 10 July 1992: Vol. 257. no. 5067, pp. 217 - 219 DOI: 10.1126/science.1352911
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Articles
Science, Vol 257, Issue 5067, 217-219
Copyright © 1992 by American Association for the Advancement of Science
Programmed death of T cells in HIV-1 infection
L Meyaard,
SA Otto,
RR Jonker,
MJ Mijnster,
RP Keet,
and
F Miedema
Department of Clinical Viro-Immunology, Central Laboratory of The Netherlands Red Cross Blood Transfusion Service, Amsterdam.
In human immunodeficiency virus (HIV) infection, functional defects and deletion of antigen-reactive T cells are more frequent than can be explained by direct viral infection. On culturing, both CD4+ and CD8+ T cells from asymptomatic HIV-infected individuals died as a result of programmed cell death (apoptosis). Apoptosis was enhanced by activation with CD3 antibodies. Programmed cell death, associated with impaired T cell reactivity, may thus be responsible for the deletion of reactive T cells that contributes to HIV-induced immunodeficiency.
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189, 1489-1496
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- Human Immunodeficiency Virus Type 1 Nef Protein Sensitizes CD4+ T Lymphoid Cells to Apoptosis via Functional Upregulation of the CD95/CD95 Ligand Pathway.
- G. Zauli, D. Gibellini, P. Secchiero, H. Dutartre, D. Olive, S. Capitani, and Y. Collette (1999)
Blood
93, 1000-1010
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- T-Cell Apoptosis in Inflammatory Neuromuscular Disorders Associated With Human Immunodeficiency Virus Infection.
- C. Schneider, M. C. Dalakas, K. V. Toyka, G. Said, H.-P. Hartung, and R. Gold (1999)
Arch Neurol
56, 79-83
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- A Novel Mechanism of CD4 Lymphocyte Depletion Involves Effects of HIV on Resting Lymphocytes: Induction of Lymph Node Homing and Apoptosis Upon Secondary Signaling Through Homing Receptors.
- L. Wang, J. J. Y. Chen, B. B. Gelman, R. Konig, and M. W. Cloyd (1999)
J. Immunol.
162, 268-276
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- Immunophenotypic Analysis of Peripheral Blood Mononuclear Cells Undergoing In Vitro Apoptosis After Isolation From Human Immunodeficiency Virus-Infected Children.
- T. W. McCloskey, S. Bakshi, S. Than, P. Arman, and S. Pahwa (1998)
Blood
92, 4230-4237
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- Induction of Programmed Cell Death by Parvovirus H-1 in U937 Cells: Connection with the Tumor Necrosis Factor Alpha Signalling Pathway.
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J. Virol.
72, 8893-8903
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- The Role of In Vitro-Induced Lymphocyte Apoptosis in Feline Immunodeficiency Virus Infection: Correlation with Different Markers of Disease Progression.
- E. Holznagel, R. Hofmann-Lehmann, C. M. Leutenegger, K. Allenspach, S. Huettner, U. Forster, E. Niederer, H. Joller, B. J. Willett, U. Hummel, et al. (1998)
J. Virol.
72, 9025-9033
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- CD4+ T-Lymphocyte Depletion in Human Lymphoid Tissue Ex Vivo Is Not Induced by Noninfectious Human Immunodeficiency Virus Type 1 Virions.
- A. W. Sylwester, J.-C. Grivel, W. Fitzgerald, J. L. Rossio, J. D. Lifson, and L. B. Margolis (1998)
J. Virol.
72, 9345-9347
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- Chronically HIV-1-Infected Monocytic Cells Induce Apoptosis in Cocultured T Cells.
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J. Immunol.
161, 4257-4267
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- CXCR4 and CD4 mediate a rapid CD95-independent cell death in CD4+ T cells.
- C. Berndt, B. Mopps, S. Angermuller, P. Gierschik, and P. H. Krammer (1998)
PNAS
95, 12556-12561
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- Apoptotic Regulation of T Cells and Absence of Immune Deficiency in Virus-Infected Gamma Interferon Receptor Knockout Mice.
- B. L. Lohman and R. M. Welsh (1998)
J. Virol.
72, 7815-7821
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- Infection with Human Immunodeficiency Virus Type 1 Upregulates DNA Methyltransferase, Resulting in De Novo Methylation of the Gamma Interferon (IFN-gamma ) Promoter and Subsequent Downregulation of IFN-gamma Production.
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Mol. Cell. Biol.
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- Role of the Fas/Fas Ligand Apoptotic Pathway in Human Immunodeficiency Virus Type 1 Disease.
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J. Virol.
72, 6279-6282
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- Synthetic peptides representing discontinuous CD4 binding epitopes of HIV-1 gp120 that induce T cell apoptosis and block cell death induced by gp120.
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FASEB J
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