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Science 17 July 1992: Vol. 257. no. 5068, pp. 389 - 395 DOI: 10.1126/science.1321501
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Articles
Science, Vol 257, Issue 5068, 389-395
Copyright © 1992 by American Association for the Advancement of Science
Structure and functional expression of an omega-conotoxin-sensitive human N-type calcium channel
ME Williams,
PF Brust,
DH Feldman,
S Patthi,
S Simerson,
A Maroufi,
AF McCue,
G Velicelebi,
SB Ellis,
and
MM Harpold
SIBIA, Inc., La Jolla, CA 92037.
N-type calcium channels are omega-conotoxin (omega-CgTx)-sensitive, voltage-dependent ion channels involved in the control of neurotransmitter release from neurons. Multiple subtypes of voltage-dependent calcium channel complexes exist, and it is the alpha 1 subunit of the complex that forms the pore through which calcium enters the cell. The primary structures of human neuronal calcium channel alpha 1B subunits were deduced by the characterization of overlapping complementary DNAs. Two forms (alpha 1B-1 and alpha 1B-2) were identified in human neuroblastoma (IMR32) cells and in the central nervous system, but not in skeletal muscle or aorta tissues. The alpha 1B-1 subunit directs the recombinant expression of N-type calcium channel activity when it is transiently co-expressed with human neuronal beta 2 and alpha 2b subunits in mammalian HEK293 cells. The recombinant channel was irreversibly blocked by omega-CgTx but was insensitive to dihydropyridines. The alpha 1B-1 alpha 2b beta 2-transfected cells displayed a single class of saturable, high-affinity (dissociation constant = 55 pM) omega-CgTx binding sites. Co-expression of the beta 2 subunit was necessary for N-type channel activity, whereas the alpha 2b subunit appeared to modulate the expression of the channel. The heterogeneity of alpha 1B subunits, along with the heterogeneity of alpha 2 and beta subunits, is consistent with multiple, biophysically distinct N-type calcium channels.
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| Full Text »
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| Abstract »
| Full Text »
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| Abstract »
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| PDF »
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| Abstract »
| Full Text »
| PDF »
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| Abstract »
| Full Text »
| PDF »
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| Abstract »
| Full Text »
| PDF »
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| Abstract »
| Full Text »
| PDF »
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| Abstract »
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- O. T. Jones, G. M. Bernstein, E. J. Jones, D. G. M. Jugloff, M. Law, W. Wong, and L. R. Mills (1997)
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17, 6152-6164
| Abstract »
| Full Text »
| PDF »
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| Abstract »
| Full Text »
| PDF »
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- L. R. Shekter, R. Taussig, S. E. Gillard, and R. J. Miller (1997)
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52, 282-291
| Abstract »
| Full Text »
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| Abstract »
| Full Text »
| PDF »
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| Abstract »
| Full Text »
| PDF »
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17, 3002-3013
| Abstract »
| Full Text »
| PDF »
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- C. A. Reid, J. D. Clements, and J. M. Bekkers (1997)
J. Neurosci.
17, 2738-2745
| Abstract »
| Full Text »
| PDF »
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J. Biol. Chem.
272, 5098-5104
| Abstract »
| Full Text »
| PDF »
- D2 Dopamine Receptors Reduce N-Type Ca2+ Currents in Rat Neostriatal Cholinergic Interneurons Through a Membrane-Delimited, Protein-Kinase-C-Insensitive Pathway.
- Z. Yan, W.-J. Song, and D. J. Surmeier (1997)
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77, 1003-1015
| Abstract »
| Full Text »
| PDF »
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- D. Wicher and H. Penzlin (1997)
J Neurophysiol
77, 186-199
| Abstract »
| Full Text »
| PDF »
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- O. Delbono, M. Gopalakrishnan, M. Renganathan, L. M. Monteggia, M. L. Messi, and J. P. Sullivan (1997)
J. Pharmacol. Exp. Ther.
280, 428-438
| Abstract »
| Full Text »
- Expression and Subunit Interaction of Voltage-Dependent Ca2+ Channels in PC12 Cells.
- H. Liu, R. Felix, C. A. Gurnett, M. De Waard, D. R. Witcher, and K. P. Campbell (1996)
J. Neurosci.
16, 7557-7565
| Abstract »
| Full Text »
| PDF »
- Functional Diversity of P-Type and R-Type Calcium Channels in Rat Cerebellar Neurons.
- A. Tottene, A. Moretti, and D. Pietrobon (1996)
J. Neurosci.
16, 6353-6363
| Abstract »
| Full Text »
| PDF »
- The alpha 1E Calcium Channel Exhibits Permeation Properties Similar to Low-Voltage-Activated Calcium Channels.
- E. Bourinet, G. W. Zamponi, A. Stea, T. W. Soong, B. A. Lewis, L. P. Jones, D. T. Yue, and T. P. Snutch (1996)
J. Neurosci.
16, 4983-4993
| Abstract »
| Full Text »
| PDF »
- Selective G-Protein Regulation of Neuronal Calcium Channels.
- P. T. Toth, L. R. Shekter, G. Hui Ma, L. H. Philipson, and R. J. Miller (1996)
J. Neurosci.
16, 4617-4624
| Abstract »
| Full Text »
| PDF »
- Roles of a Membrane-localized beta Subunit in the Formation and Targeting of Functional L-type Ca[IMAGE] Channels.
- A. J. Chien, X. Zhao, R. E. Shirokov, T. S. Puri, C. F. Chang, D. Sun, E. Rios, and M. M. Hosey (1995)
J. Biol. Chem.
270, 30036-30044
| Abstract »
| Full Text »
| PDF »
- Essential Ca2+-Binding Motif for Ca2+-Sensitive Inactivation of L-Type Ca2+ Channels.
- M. de Leon, Y. Wang, L. Jones, E. Perez-Reyes, X. Wei, T. W. Soong, T. P. Snutch, and D. T. Yue (1995)
Science
270, 1502-1506
| Abstract »
| PDF »
- Immunochemical Identification and Differential Phosphorylation of Alternatively Spliced Forms of the alpha[IMAGE] Subunit of Brain Calcium Channels.
- T. Sakurai, J. W. Hell, A. Woppmann, G. P. Miljanich, and W. A. Catterall (1995)
J. Biol. Chem.
270, 21234-21242
| Abstract »
| Full Text »
| PDF »
- Stable Expression and Coupling of Cardiac L-Type Ca2+ Channels With ß1-Adrenoceptors.
- A. Yatani, M. Wakamori, T. Niidome, S. Yamamoto, I. Tanaka, Y. Mori, K. Katayama, and S. Green (1995)
Circ. Res.
76, 335-342
| Abstract »
| Full Text »
- Functional consequences of posttranslational isomerization of Ser46 in a calcium channel toxin.
- S. Heck, C. Siok, K. Krapcho, P. Kelbaugh, P. Thadeio, M. Welch, R. Williams, A. Ganong, M. Kelly, A. Lanzetti, et al. (1994)
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266, 1065-1068
| Abstract »
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- Subunit identification and reconstitution of the N-type Ca2+ channel complex purified from brain.
- D. Witcher, M De Waard, J Sakamoto, C Franzini-Armstrong, M Pragnell, S. Kahl, and K. Campbell (1993)
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261, 486-489
| Abstract »
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- Structure and functional expression of a member of the low voltage-activated calcium channel family.
- T. Soong, A Stea, C. Hodson, S. Dubel, Vincent SR, and T. Snutch (1993)
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260, 1133-1136
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- C. B. Cooper, M. I. Arnot, Z.-P. Feng, S. E. Jarvis, J. Hamid, and G. W. Zamponi (2000)
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- Functional disorders of the sympathetic nervous system in mice lacking the alpha 1B subunit (Cav 2.2) of N-type calcium channels.
- M. Ino, T. Yoshinaga, M. Wakamori, N. Miyamoto, E. Takahashi, J. Sonoda, T. Kagaya, T. Oki, T. Nagasu, Y. Nishizawa, et al. (2001)
PNAS
98, 5323-5328
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