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Science 17 July 1992:
Vol. 257. no. 5068, pp. 398 - 401
DOI: 10.1126/science.1321503
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Articles
Science, Vol 257, Issue 5068, 398-401
Copyright © 1992 by American Association for the Advancement of Science
The role of GABAB receptor activation in absence seizures of lethargic (lh/lh) mice
DA Hosford,
S Clark,
Z Cao,
WA Wilson Jr,
FH Lin,
RA Morrisett,
and
A Huin
Department of Medicine, Duke University, Durham, NC.
Lethargic (lh/lh) mice, which function as an animal model of absence seizures, have spontaneous seizures that have behavioral and electrographic features and anticonvulsant sensitivity similar to those of human absence seizures. Antagonists of the gamma-aminobutyric acidB (GABAB) receptor suppressed these seizures in lethargic mice, whereas agonists of GABAB receptors exacerbated them. Furthermore, GABAB receptor binding and synaptically evoked GABAB receptor-mediated inhibition of N-methyl-D-aspartate responses were selectively increased in lh/lh mice. Therefore, enhanced GABAB receptor-mediated synaptic responses may underlie absence seizures in lh/lh mice, and GABAB receptor antagonists hold promise as anticonvulsants for absence seizures.
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