Science 17 July 1992: Vol. 257. no. 5068, pp. 401 - 403 DOI: 10.1126/science.1378650

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Articles

Hypercontractility and impaired sildenafil relaxations in the BKCa channel deletion model of erectile dysfunction.

M. E. Werner, A. L. Meredith, R. W. Aldrich, and M. T. Nelson (2008)
Am J Physiol Regulatory Integrative Comp Physiol 295, R181-R188
 |  Abstract »  |  Full Text »  |  PDF »

A Mutation in the Inner Mitochondrial Membrane Peptidase 2-Like Gene (Immp2l) Affects Mitochondrial Function and Impairs Fertility in Mice.

B. Lu, C. Poirier, T. Gaspar, C. Gratzke, W. Harrison, D. Busija, M. M. Matzuk, K.-E. Andersson, P. A. Overbeek, and C. E. Bishop (2008)
Biol Reprod 78, 601-610
 |  Abstract »  |  Full Text »  |  PDF »

Penile erection and micturition events triggered by electrical stimulation of the mesopontine tegmental area.

J. C. T. Salas, H. Iwasaki, E. Jodo, M. H. Schmidt, A. Kawauchi, T. Miki, Y. Kayama, M. Otsuki, and Y. Koyama (2008)
Am J Physiol Regulatory Integrative Comp Physiol 294, R102-R111
 |  Abstract »  |  Full Text »  |  PDF »

Alterations of NOS, arginase, and DDAH protein expression in rabbit cavernous tissue after administration of cigarette smoke extract.

M. Imamura, Y. Waseda, G. V. Marinova, T. Ishibashi, S. Obayashi, A. Sasaki, A. Nagai, and H. Azuma (2007)
Am J Physiol Regulatory Integrative Comp Physiol 293, R2081-R2089
 |  Abstract »  |  Full Text »  |  PDF »

Evidence that the vasodilator angiotensin-(1 7)-Mas axis plays an important role in erectile function.

A. C. da Costa Goncalves, R. Leite, R. A. Fraga-Silva, S. V. Pinheiro, A. B. Reis, F. M. Reis, R. M. Touyz, R. C. Webb, N. Alenina, M. Bader, et al. (2007)
Am J Physiol Heart Circ Physiol 293, H2588-H2596
 |  Abstract »  |  Full Text »  |  PDF »

Effects of 5-Cyclopropyl-2-[1-(2-fluoro-benzyl)-1H-pyrazolo[3,4-b]pyridine-3-yl]pyrimidin-4-ylamine (BAY 41-2272) on Smooth Muscle Tone, Soluble Guanylyl Cyclase Activity, and NADPH Oxidase Activity/Expression in Corpus Cavernosum from Wild-Type, Neuronal, and Endothelial Nitric-Oxide Synthase Null Mice.

C. E. Teixeira, F. B. M. Priviero, and R. C. Webb (2007)
J. Pharmacol. Exp. Ther. 322, 1093-1102
 |  Abstract »  |  Full Text »  |  PDF »

Overexpression of arginase in the aged mouse penis impairs erectile function and decreases eNOS activity: influence of in vivo gene therapy of anti-arginase.

T. J. Bivalacqua, A. L. Burnett, W. J. G. Hellstrom, and H. C. Champion (2007)
Am J Physiol Heart Circ Physiol 292, H1340-H1351
 |  Abstract »  |  Full Text »  |  PDF »

Mesenchymal stem cells alone or ex vivo gene modified with endothelial nitric oxide synthase reverse age-associated erectile dysfunction.

T. J. Bivalacqua, W. Deng, M. Kendirci, M. F. Usta, C. Robinson, B. K. Taylor, S. N. Murthy, H. C. Champion, W. J. G. Hellstrom, and P. J. Kadowitz (2007)
Am J Physiol Heart Circ Physiol 292, H1278-H1290
 |  Abstract »  |  Full Text »  |  PDF »

Erectile Dysfunction in Heart Failure Patients.

E. R. Schwarz, S. Rastogi, V. Kapur, N. Sulemanjee, and J. J. Rodriguez (2006)
J. Am. Coll. Cardiol. 48, 1111-1119
 |  Abstract »  |  Full Text »  |  PDF »

Tetrahydrobiopterin Protects against Guanabenz-Mediated Inhibition of Neuronal Nitric-Oxide Synthase in Vitro and in Vivo.

A. Y. Dunbar, G. J. Jenkins, S. Jianmongkol, M. Nakatsuka, E. R. Lowe, M. Lau, and Y. Osawa (2006)
Drug Metab. Dispos. 34, 1448-1456
 |  Abstract »  |  Full Text »  |  PDF »

Role of Oxidative Stress in the Pathophysiological Mechanism of Erectile Dysfunction.

A. Agarwal, K. C. Nandipati, R. K. Sharma, C. D. Zippe, and R. Raina (2006)
J Androl 27, 335-347
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Penile erection requires association of soluble guanylyl cyclase with endothelial caveolin-1 in rat corpus cavernosum.

A. E. Linder, R. Leite, K. Lauria, T. M. Mills, and R. C. Webb (2006)
Am J Physiol Regulatory Integrative Comp Physiol 290, R1302-R1308
 |  Abstract »  |  Full Text »  |  PDF »

Alternatively spliced neuronal nitric oxide synthase mediates penile erection.

K. J. Hurt, S. F. Sezen, H. C. Champion, J. K. Crone, M. A. Palese, P. L. Huang, A. Sawa, X. Luo, B. Musicki, S. H. Snyder, et al. (2006)
PNAS 103, 3440-3443
 |  Abstract »  |  Full Text »  |  PDF »

eNOS Function and Dysfunction in the Penis.

B. Musicki and A. L. Burnett (2006)
Experimental Biology and Medicine 231, 154-165
 |  Abstract »  |  Full Text »  |  PDF »

Erectile dysfunction in mice lacking the large-conductance calcium-activated potassium (BK) channel.

M. E. Werner, P. Zvara, A. L. Meredith, R. W. Aldrich, and M. T. Nelson (2005)
J. Physiol. 567, 545-556
 |  Abstract »  |  Full Text »  |  PDF »

Inactivation of phosphorylated endothelial nitric oxide synthase (Ser-1177) by O-GlcNAc in diabetes-associated erectile dysfunction.

B. Musicki, M. F. Kramer, R. E. Becker, and A. L. Burnett (2005)
PNAS 102, 11870-11875
 |  Abstract »  |  Full Text »  |  PDF »

Expression of PDE11A in Normal and Malignant Human Tissues.

M. R. D'Andrea, Y. Qiu, D. Haynes-Johnson, S. Bhattacharjee, P. Kraft, and S. Lundeen (2005)
J. Histochem. Cytochem. 53, 895-903
 |  Abstract »  |  Full Text »  |  PDF »

Erection Capability Is Potentiated by Long-Term Sildenafil Treatment: Role of Blood Flow-Induced Endothelial Nitric-Oxide Synthase Phosphorylation.

B. Musicki, H. C. Champion, R. E. Becker, T. Liu, M. F. Kramer, and A. L. Burnett (2005)
Mol. Pharmacol. 68, 226-232
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of intracellular Ca2+ release in corpus cavernosum smooth muscle: synergism between nitric oxide and cGMP.

B. A. Williams, C. Liu, L. DeYoung, G. B. Brock, and S. M. Sims (2005)
Am J Physiol Cell Physiol 288, C650-C658
 |  Abstract »  |  Full Text »  |  PDF »

Phosphodiesterase-5A dysregulation in penile erectile tissue is a mechanism of priapism.

H. C. Champion, T. J. Bivalacqua, E. Takimoto, D. A. Kass, and A. L. Burnett (2005)
PNAS 102, 1661-1666
 |  Abstract »  |  Full Text »  |  PDF »

Downregulation of cGMP-dependent protein kinase-1 activity in the corpus cavernosum smooth muscle of diabetic rabbits.

S. Chang, J. A. Hypolite, M. Velez, A. Changolkar, A. J. Wein, S. Chacko, and M. E. DiSanto (2004)
Am J Physiol Regulatory Integrative Comp Physiol 287, R950-R960
 |  Abstract »  |  Full Text »  |  PDF »

Oxidative Stress and Antioxidant Therapy: Their Impact in Diabetes-Associated Erectile Dysfunction.

L. De Young, D. Yu, R. M. Bateman, and G. B. Brock (2004)
J Androl 25, 830-836
 |  Abstract »  |  Full Text »  |  PDF »

Heme Oxygenase-2 Is Activated by Calcium-Calmodulin.

D. Boehning, L. Sedaghat, T. W. Sedlak, and S. H. Snyder (2004)
J. Biol. Chem. 279, 30927-30930
 |  Abstract »  |  Full Text »  |  PDF »

RhoA/Rho-kinase suppresses endothelial nitric oxide synthase in the penis: A mechanism for diabetes-associated erectile dysfunction.

T. J. Bivalacqua, H. C. Champion, M. F. Usta, S. Cellek, K. Chitaley, R. C. Webb, R. L. Lewis, T. M. Mills, W. J. G. Hellstrom, and P. J. Kadowitz (2004)
PNAS 101, 9121-9126
 |  Abstract »  |  Full Text »  |  PDF »

Role of Nitric Oxide Concentrations on Human Sperm Motility.

G. Balercia, S. Moretti, A. Vignini, M. Magagnini, F. Mantero, M. Boscaro, G. Ricciardo-Lamonica, and L. Mazzanti (2004)
J Androl 25, 245-249
 |  Abstract »  |  Full Text »  |  PDF »

Phosphorylated Endothelial Nitric Oxide Synthase Mediates Vascular Endothelial Growth Factor-Induced Penile Erection.

B. Musicki, M. A. Palese, J. K. Crone, and A. L. Burnett (2004)
Biol Reprod 70, 282-289
 |  Abstract »  |  Full Text »  |  PDF »

A Twin Study of Erectile Dysfunction.

M. E. Fischer, M. E. Vitek, D. Hedeker, W. G. Henderson, S. J. Jacobsen, and J. Goldberg (2004)
Arch Intern Med 164, 165-168
 |  Abstract »  |  Full Text »  |  PDF »

Endothelial Dysfunction in Erectile Dysfunction: Role of the Endothelium in Erectile Physiology and Disease.

T. J. Bivalacqua, M. F. Usta, H. C. Champion, P. J. Kadowitz, and W. J. G. Hellstrom (2003)
J Androl 24, S17-S37
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Adenoviral gene transfer of eNOS: high-level expression in ex vivo expanded marrow stromal cells.

W. Deng, T. J. Bivalacqua, N. N. Chattergoon, A. L. Hyman, J. R. Jeter Jr., and P. J. Kadowitz (2003)
Am J Physiol Cell Physiol 285, C1322-C1329
 |  Abstract »  |  Full Text »  |  PDF »

The Pharmacology of Nitric Oxide in the Peripheral Nervous System of Blood Vessels.

N. Toda and T. Okamura (2003)
Pharmacol. Rev. 55, 271-324
 |  Abstract »  |  Full Text »  |  PDF »

Nitric Oxide Signaling in Brain: Potentiating the Gain with YC-1.

D. S. Bredt (2003)
Mol. Pharmacol. 63, 1206-1208
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Gene transfer of extracellular SOD to the penis reduces O₂⁻{middle dot} and improves erectile function in aged rats.

T. J. Bivalacqua, J. S. Armstrong, J. Biggerstaff, A. B. Abdel-Mageed, P. J. Kadowitz, W. J. G. Hellstrom, and H. C. Champion (2003)
Am J Physiol Heart Circ Physiol 284, H1408-H1421
 |  Abstract »  |  Full Text »  |  PDF »

Proteolytic Degradation of Nitric Oxide Synthase: Effect of Inhibitors and Role of hsp90-Based Chaperones.

Y. Osawa, E. R. Lowe, A. C. Everett, A. Y. Dunbar, and S. S. Billecke (2003)
J. Pharmacol. Exp. Ther. 304, 493-497
 |  Abstract »  |  Full Text »  |  PDF »

Ca2+-activated Cl- channels in corpus cavernosum smooth muscle: a novel mechanism for control of penile erection.

T. Karkanis, L. DeYoung, G. B. Brock, and S. M. Sims (2003)
J Appl Physiol 94, 301-313
 |  Abstract »  |  Full Text »  |  PDF »

The Effectiveness of Treatments of Diabetic Autonomic Neuropathy Is Not the Same in Autonomic Nerves Supplying Different Organs.

H. R. Shotton, S. Clarke, and J. Lincoln (2003)
Diabetes 52, 157-164
 |  Abstract »  |  Full Text »  |  PDF »

Forty Years of Neurotransmitters: A Personal Account.

S. H. Snyder (2002)
Arch Gen Psychiatry 59, 983-994
 |  Abstract »  |  Full Text »  |  PDF »

The Molecular Basis of Erectile Physiology: From Bench to Bedside.

W. J. G. Hellstrom (2002)
J Androl 23, S3-S4
 |  Full Text »  |  PDF »

Nitric Oxide Regulation of Penile Erection: Biology and Therapeutic Implications.

A. L. Burnett (2002)
J Androl 23, S20-S26
 |  Full Text »  |  PDF »

Guanylate Cyclase Activity and Sperm Function.

A. Revelli, D. Ghigo, F. Moffa, M. Massobrio, and I. Tur-Kaspa (2002)
Endocr. Rev. 23, 484-494
 |  Abstract »  |  Full Text »  |  PDF »

The pathophysiology of erectile dysfunction related to endothelial dysfunction and mediators of vascular function.

R. Maas, E. Schwedhelm, J. Albsmeier, and R. H Boger (2002)
Vascular Medicine 7, 213-225
 |  Abstract »  |  PDF »

Deletion of Exon 6 of the Neuronal Nitric Oxide Synthase Gene in Mice Results in Hypogonadism and Infertility.

R. Gyurko, S. Leupen, and P. L. Huang (2002)
Endocrinology 143, 2767-2774
 |  Abstract »  |  Full Text »  |  PDF »

Akt-dependent phosphorylation of endothelial nitric-oxide synthase mediates penile erection.

K. J. Hurt, B. Musicki, M. A. Palese, J. K. Crone, R. E. Becker, J. L. Moriarity, S. H. Snyder, and A. L. Burnett (2002)
PNAS 99, 4061-4066
 |  Abstract »  |  Full Text »  |  PDF »

An Alternative Promoter of the Human Neuronal Nitric Oxide Synthase Gene Is Expressed Specifically in Leydig Cells.

Y. Wang, D. C. Newton, T. L. Miller, A.-M. Teichert, M. J. Phillips, M. S. Davidoff, and P. A. Marsden (2002)
Am. J. Pathol. 160, 369-380
 |  Abstract »  |  Full Text »  |  PDF »

Gene Transfer of Prepro-Calcitonin Gene-Related Peptide Restores Erectile Function in the Aged Rat.

T. J. Bivalacqua, H. C. Champion, A. B. Abdel-Mageed, P. J. Kadowitz, and W. J.G. Hellstrom (2001)
Biol Reprod 65, 1371-1377
 |  Abstract »  |  Full Text »  |  PDF »

Neural roles for heme oxygenase: Contrasts to nitric oxide synthase.

D. E. Baranano and S. H. Snyder (2001)
PNAS 98, 10996-11002
 |  Abstract »  |  Full Text »  |  PDF »

Pharmacology of Penile Erection.

K.-E. Andersson (2001)
Pharmacol. Rev. 53, 417-450
 |  Abstract »  |  Full Text »  |  PDF »

The Relaxation Induced by S-Nitroso-Glutathione and S-Nitroso-N-Acetylcysteine in Rat Aorta Is Not Related to Nitric Oxide Production.

P. I. B. Ceron, D. C. Cremonez, L. M. Bendhack, and A. C. Tedesco (2001)
J. Pharmacol. Exp. Ther. 298, 686-694
 |  Abstract »  |  Full Text »  |  PDF »

Multiple Pathways of Angiotensin I Conversion and Their Functional Role in the Canine Penile Corpus Cavernosum.

Y. Iwamoto, K. Song, S. Takai, M. Yamada, D. Jin, M. Sakaguchi, H. Ueda, Y. Katsuoka, and M. Miyazaki (2001)
J. Pharmacol. Exp. Ther. 298, 43-48
 |  Abstract »  |  Full Text »

Central modulation of the NO/cGMP pathway affects the MPOA-induced intracavernous pressure response.

Y. Sato, W. Zhao, and G. J. Christ (2001)
Am J Physiol Regulatory Integrative Comp Physiol 281, R269-R278
 |  Abstract »  |  Full Text »  |  PDF »

Long-term effects on male reproduction of early exposure to common chemical contaminants in drinking water.

D.N.R. Veeramachaneni, J.S. Palmer, and R.P. Amann (2001)
Hum. Reprod. 16, 979-987
 |  Abstract »  |  Full Text »  |  PDF »

Nitric Oxide and Cnidarian-Dinoflagellate Symbioses: Pieces of a Puzzle.

H. G. Trapido-Rosenthal, K. H. Sharp, T. S. Galloway, and C. E. Morrall (2001)
Integr. Comp. Biol. 41, 247-257
 |  Abstract »  |  Full Text »  |  PDF »

Seminal plasma nitrite/nitrate and intratesticular Doppler flow in fertile and infertile subjects.

C. Battaglia, S. Giulini, G. Regnani, R. Di Girolamo, S. Paganelli, F. Facchinetti, and A. Volpe (2000)
Hum. Reprod. 15, 2554-2558
 |  Abstract »  |  Full Text »  |  PDF »

Rationale for the Combination of PGE1 and S-Nitroso-glutathione to Induce Relaxation of Human Penile Smooth Muscle.

J. Angulo, P. Cuevas, I. Moncada, A. Martín-Morales, A. Allona, A. Fernández, S. Gabancho, P. Ney, and I. S. de Tejada (2000)
J. Pharmacol. Exp. Ther. 295, 586-593
 |  Abstract »  |  Full Text »

Novel Neurotransmitters and Their Neuropsychiatric Relevance.

S. H. Snyder and C. D. Ferris (2000)
Am J Psychiatry 157, 1738-1751
 |  Abstract »  |  Full Text »

Potentiation of Penile Tumescence by T-1032, a New Potent and Specific Phosphodiesterase Type V Inhibitor, in Dogs.

T. Noto, H. Inoue, T. Ikeo, and K. Kikkawa (2000)
J. Pharmacol. Exp. Ther. 294, 870-875
 |  Abstract »  |  Full Text »

Expression of Penile Neuronal Nitric Oxide Synthase Variants in the Rat and Mouse Penile Nerves.

N. F. Gonzalez-Cadavid, A. L. Burnett, T. R. Magee, C. B. Zeller, D. Vernet, N. Smith, J. Gitter, and J. Rajfer (2000)
Biol Reprod 63, 704-714
 |  Abstract »  |  Full Text »

Nitric Oxide Synthase Inhibition in Human Sperm Affects Sperm-Oocyte Fusion but Not Zona Pellucida Binding.

F. Francavilla, R. Santucci, B. Macerola, G. Ruvolo, and R. Romano (2000)
Biol Reprod 63, 425-429
 |  Abstract »  |  Full Text »

Guanabenz-mediated Inactivation and Enhanced Proteolytic Degradation of Neuronal Nitric-oxide Synthase.

S. Noguchi, S. Jianmongkol, A. T. Bender, Y. Kamada, D. R. Demady, and Y. Osawa (2000)
J. Biol. Chem. 275, 2376-2380
 |  Abstract »  |  Full Text »  |  PDF »

Glucose-induced changes in protein kinase C and nitric oxide are prevented by vitamin E.

M. B. Ganz and A. Seftel (2000)
Am J Physiol Endocrinol Metab 278, E146-E152
 |  Abstract »  |  Full Text »  |  PDF »

Temperature conditioning of nasal air: effects of vasoactive agents and involvement of nitric oxide.

W. E. Holden, J. P. Wilkins, M. Harris, H. A. Milczuk, and G. D. Giraud (1999)
J Appl Physiol 87, 1260-1265
 |  Abstract »  |  Full Text »  |  PDF »

Gene transfer of endothelial nitric oxide synthase to the penis augments erectile responses in the aged rat.

H. C. Champion, T. J. Bivalacqua, A. L. Hyman, L. J. Ignarro, W. J. G. Hellstrom, and P. J. Kadowitz (1999)
PNAS 96, 11648-11652
 |  Abstract »  |  Full Text »  |  PDF »

Parathyroid Hormone-Related Protein in Rat Penis: Expression, Localization, and Effect on Cavernosal Pressure.

H. Lang, N. Endlich, V. Lindner, K. Endlich, T. Massfelder, A. F. Stewart, C. Saussine, and J.-J. Helwig (1999)
Endocrinology 140, 4342-4350
 |  Abstract »  |  Full Text »

Nitric oxide and penile erection: Is erectile dysfunction another manifestation of vascular disease?.

M. E. Sullivan, C. S. Thompson, M. R. Dashwood, M. A. Khan, J. Y. Jeremy, R. J. Morgan, and D. P. Mikhailidis (1999)
Cardiovasc Res 43, 658-665
 |  Abstract »  |  Full Text »  |  PDF »

Design and Evaluation of Nitrosylated alpha -Adrenergic Receptor Antagonists as Potential Agents for the Treatment of Impotence.

I. S. de Tejada, D. S. Garvey, J. D. Schroeder, T. Shelekhin, L. G. Letts, A. Fernández, B. Cuevas, S. Gabancho, V. Martínez, J. Angulo, et al. (1999)
J. Pharmacol. Exp. Ther. 290, 121-128
 |  Abstract »  |  Full Text »

Cyclic GMP Phosphodiesterase-5: Target of Sildenafil.

J. D. Corbin and S. H. Francis (1999)
J. Biol. Chem. 274, 13729-13732
 |  Full Text »  |  PDF »

NO skeletal muscle derived relaxing factor in Duchenne muscular dystrophy.

D. S. Bredt (1998)
PNAS 95, 14592-14593
 |  Full Text »  |  PDF »

Physiological Features of Visceral Smooth Muscle Cells, With Special Reference to Receptors and Ion Channels.

H. KURIYAMA, K. KITAMURA, T. ITOH, and R. INOUE (1998)
Physiol Rev 78, 811-920
 |  Abstract »  |  Full Text »  |  PDF »

Does Nitric Oxide Play a Critical Role in Viral Infections?.

C. S. Reiss and T. Komatsu (1998)
J. Virol. 72, 4547-4551
 |  Full Text »  |  PDF »

Metabolism-Based Inactivation of Penile Nitric Oxide Synthase Activity by Guanabenz.

M. Nakatsuka, K. Nakatsuka, and Y. Osawa (1998)
Drug Metab. Dispos. 26, 497-501
 |  Abstract »  |  Full Text »

Monkey corpus cavernosum relaxation mediated by NO and other relaxing factor derived from nerves.

T. Okamura, K. Ayajiki, and N. Toda (1998)
Am J Physiol Heart Circ Physiol 274, H1075-H1081
 |  Abstract »  |  Full Text »  |  PDF »

Nitric oxide and vasodilation in human limbs.

M. J. Joyner and N. M. Dietz (1997)
J Appl Physiol 83, 1785-1796
 |  Abstract »  |  Full Text »  |  PDF »

Pelvic nerve stimulation-induced pressor responses in corpus cavernosum of anesthetized dogs.

K. Ayajiki, H. Hayashida, T. Okamura, and N. Toda (1997)
Am J Physiol Heart Circ Physiol 273, H2141-H2145
 |  Abstract »  |  Full Text »  |  PDF »

Nitric oxide in the contractile action of bradykinin, oxytocin, and prostaglandin F2 alpha  in the estrogenized rat uterus.

M. Chaud, A. M. Franchi, V. Rettori, S. M. McCann, and M. F. Gimeno (1997)
PNAS 94, 11049-11054
 |  Abstract »  |  Full Text »  |  PDF »

A Novel, Testis-specific mRNA Transcript Encoding an NH2-terminal Truncated Nitric-oxide Synthase.

Y. Wang, M. S. Goligorsky, M. Lin, J. N. Wilcox, and P. A. Marsden (1997)
J. Biol. Chem. 272, 11392-11401
 |  Abstract »  |  Full Text »  |  PDF »

REVIEW {blacksquare} : Nitric Oxide: Actions and Pathological Roles.

T. M. Dawson and V. L. Dawson (1995)
Neuroscientist 1, 7-18
 |  Abstract »  |  PDF »

Fortnightly Review Biology and clinical relevance of nitric oxide.

P Vallance and J Collier (1994)
BMJ 309, 453-7
 |  Full Text »

The L-Arginine-Nitric Oxide Pathway.

S. Moncada and A. Higgs (1993)
N. Engl. J. Med. 329, 2002-2012
 |  Full Text »

Nitric oxide: first in a new class of neurotransmitters.

S. Snyder (1992)
Science 257, 494-496
 |  PDF »

Structural Basis for Pterin Antagonism in Nitric-oxide Synthase. DEVELOPMENT OF NOVEL 4-OXO-PTERIDINE ANTAGONISTS OF (6R)-5,6,7,8-TETRAHYDROBIOPTERIN.

P. Kotsonis, L. G. Frohlich, C. S. Raman, H. Li, M. Berg, R. Gerwig, V. Groehn, Y. Kang, N. Al-Masoudi, S. Taghavi-Moghadam, et al. (2001)
J. Biol. Chem. 276, 49133-49141
 |  Abstract »  |  Full Text »  |  PDF »

Erectile dysfunction in cyclic GMP-dependent kinase I-deficient mice.

P. Hedlund, A. Aszodi, A. Pfeifer, P. Alm, F. Hofmann, M. Ahmad, R. Fassler, and K.-E. Andersson (2000)
PNAS 97, 2349-2354
 |  Abstract »  |  Full Text »  |  PDF »

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