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Science 24 July 1992:
Vol. 257. no. 5069, pp. 522 - 523
DOI: 10.1126/science.1636086
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Articles

Science, Vol 257, Issue 5069, 522-523
Copyright © 1992 by American Association for the Advancement of Science

articles

Magnetoferritin: in vitro synthesis of a novel magnetic protein

FC Meldrum, BR Heywood, and S Mann

School of Chemistry, University of Bath, United Kingdom.

The iron storage protein ferritin consists of a spherical polypeptide shell (apoferritin) surrounding a 6-nanometer inorganic core of the hydrated iron oxide ferrihydrite (5Fe2O3.9H2O). Previous studies have shown that the in vitro reconstitution of apoferritin yields mineral cores essentially identical to those of the native proteins. A magnetic mineral was synthesized within the nanodimensional cavity of horse spleen ferritin by the use of controlled reconstitution conditions. Transmission electron microscopy and electron diffraction analysis indicate that the entrapped mineral particles are discrete 6-nanometer spherical single crystals of the ferrimagnetic iron oxide magnetite (Fe3O4). The resulting magnetic protein, "magnetoferritin," could have uses in biomedical imaging, cell labeling, and separation procedures.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Controlled Aggregation of Ferritin to Modulate MRI Relaxivity.
K. M. Bennett, E. M. Shapiro, C. H. Sotak, and A. P. Koretsky (2008)
Biophys. J. 95, 342-351
   Abstract »    Full Text »    PDF »
A Novel Protein Tightly Bound to Bacterial Magnetic Particles in Magnetospirillum magneticum Strain AMB-1.
A. Arakaki, J. Webb, and T. Matsunaga (2003)
J. Biol. Chem. 278, 8745-8750
   Abstract »    Full Text »    PDF »
Synthesis and Structure of an Iron(III) Sulfide-Ferritin Bioinorganic Nanocomposite.
T. Douglas, D. P. E. Dickson, S. Betteridge, J. Charnock, C. D. Garner, and S. Mann (1995)
Science 269, 54-57
   Abstract »    PDF »
Classical and quantum magnetic phenomena in natural and artificial ferritin proteins.
S Gider, D. Awschalom, T Douglas, S Mann, and M Chaparala (1995)
Science 268, 77-80
   Abstract »    PDF »
Large Clusters of Metal Ions: The Transition from Molecular to Bulk Magnets.
D. Gatteschi, A. Caneschi, L. Pardi, and R. Sessoli (1994)
Science 265, 1054-1058
   Abstract »    PDF »
A mixed-valent polyiron oxo complex that models the biomineralization of the ferritin core.
K. Taft, G. Papaefthymiou, and S. Lippard (1993)
Science 259, 1302-1305
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)