Science 7 August 1992: Vol. 257. no. 5071, pp. 792 - 795 DOI: 10.1126/science.1496399

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Articles

CTLA-4 directly inhibits osteoclast formation.

R Axmann, S Herman, M Zaiss, S Franz, K Polzer, J Zwerina, M Herrmann, J Smolen, and G Schett (2008)
Ann Rheum Dis 67, 1603-1609
 |  Abstract »  |  Full Text »  |  PDF »

PD-1-Dependent Mechanisms Maintain Peripheral Tolerance of Donor-Reactive CD8+ T Cells to Transplanted Tissue.

B. H. Koehn, M. L. Ford, I. R. Ferrer, K. Borom, S. Gangappa, A. D. Kirk, and C. P. Larsen (2008)
J. Immunol. 181, 5313-5322
 |  Abstract »  |  Full Text »  |  PDF »

CTLA4 Expression Is an Indicator and Regulator of Steady-State CD4+FoxP3+ T Cell Homeostasis.

A. L. Tang, J. R. Teijaro, M. N. Njau, S. S. Chandran, A. Azimzadeh, S. G. Nadler, D. M. Rothstein, and D. L. Farber (2008)
J. Immunol. 181, 1806-1813
 |  Abstract »  |  Full Text »  |  PDF »

Lack of Repeat Transduction by Recombinant Adeno-Associated Virus Type 5/5 Vectors in the Mouse Airway.

S. G. Sumner-Jones, D. R. Gill, and S. C. Hyde (2007)
J. Virol. 81, 12360-12367
 |  Abstract »  |  Full Text »  |  PDF »

The Activating Immunoreceptor NKG2D and Its Ligands Are Involved in Allograft Transplant Rejection.

J. Kim, C. K. Chang, T. Hayden, F.-C. Liu, J. Benjamin, J. A. Hamerman, L. L. Lanier, and S.-M. Kang (2007)
J. Immunol. 179, 6416-6420
 |  Abstract »  |  Full Text »  |  PDF »

Calcineurin Inhibitors Block MHC-Restricted Antigen Presentation In Vivo.

Y.-H. Lee, Y.-R. Lee, S.-A Im, S.-I. Park, K.-H. Kim, T. Gerelchuluun, S. Song, K. Kim, and C.-K. Lee (2007)
J. Immunol. 179, 5711-5716
 |  Abstract »  |  Full Text »  |  PDF »

Costimulation Blockade Inhibits Allergic Sensitization but Does Not Affect Established Allergy in a Murine Model of Grass Pollen Allergy.

B. Linhart, S. Bigenzahn, A. Hartl, C. Lupinek, J. Thalhamer, R. Valenta, and T. Wekerle (2007)
J. Immunol. 178, 3924-3931
 |  Abstract »  |  Full Text »  |  PDF »

Control of Memory CD4 T Cell Recall by the CD28/B7 Costimulatory Pathway.

M. P. Ndejembi, J. R. Teijaro, D. S. Patke, A. W. Bingaman, M. R. Chandok, A. Azimzadeh, S. G. Nadler, and D. L. Farber (2006)
J. Immunol. 177, 7698-7706
 |  Abstract »  |  Full Text »  |  PDF »

Creation of tolerogenic human dendritic cells via intracellular CTLA4: a novel strategy with potential in clinical immunosuppression.

P. H. Tan, J. B. Yates, S.-A. Xue, C. Chan, W. J. Jordan, J. E. Harper, M. P. Watson, R. Dong, M. A. Ritter, R. I. Lechler, et al. (2005)
Blood 106, 2936-2943
 |  Abstract »  |  Full Text »  |  PDF »

Block and tackle: CTLA4Ig takes on lupus.

A Davidson, B Diamond, D Wofsy, and D Daikh (2005)
Lupus 14, 197-203
 |  Abstract »  |  PDF »

Prevention of lethal acute GVHD with an agonistic CD28 antibody and rapamycin.

M. H. Albert, X.-Z. Yu, P. J. Martin, and C. Anasetti (2005)
Blood 105, 1355-1361
 |  Abstract »  |  Full Text »  |  PDF »

Role of B7 in T Cell Tolerance.

J. Lohr, B. Knoechel, E. C. Kahn, and A. K. Abbas (2004)
J. Immunol. 173, 5028-5035
 |  Abstract »  |  Full Text »  |  PDF »

CTLA4Ig: a novel inhibitor of costimulation.

M Dall'Era and J Davis (2004)
Lupus 13, 372-376
 |  Abstract »  |  PDF »

Regulation of Postsurgical Fibrosis by the Programmed Death-1 Inhibitory Pathway.

M. A. Holsti, T. Chitnis, R. J. Panzo, R. T. Bronson, H. Yagita, M. H. Sayegh, and A. O. Tzianabos (2004)
J. Immunol. 172, 5774-5781
 |  Abstract »  |  Full Text »  |  PDF »

CD86 and CD80 Differentially Modulate the Suppressive Function of Human Regulatory T Cells.

Y. Zheng, C. N. Manzotti, M. Liu, F. Burke, K. I. Mead, and D. M. Sansom (2004)
J. Immunol. 172, 2778-2784
 |  Abstract »  |  Full Text »  |  PDF »

Use of localised gene transfer to develop new treatment strategies for the salivary component of Sjogren's syndrome.

M R Kok, B J Baum, P P Tak, and S R Pillemer (2003)
Ann Rheum Dis 62, 1038-1046
 |  Abstract »  |  Full Text »  |  PDF »

Induction of Specific T-Cell Responses, Opsonizing Antibodies, and Protection against Plasmodium chabaudi adami Infection in Mice Vaccinated with Genomic Expression Libraries Expressed in Targeted and Secretory DNA Vectors.

A. Rainczuk, T. Scorza, P. M. Smooker, and T. W. Spithill (2003)
Infect. Immun. 71, 4506-4515
 |  Abstract »  |  Full Text »  |  PDF »

Mechanism of Reduced T-Cell Effector Functions and Class-Switched Antibody Responses to Herpes Simplex Virus Type 2 in the Absence of B7 Costimulation.

L. G. Thebeau and L. A. Morrison (2003)
J. Virol. 77, 2426-2435
 |  Abstract »  |  Full Text »  |  PDF »

Memory Th2 Effector Cells Can Develop in the Absence of B7-1/B7-2, CD28 Interactions, and Effector Th Cells After Priming with an Intestinal Nematode Parasite.

M. J. Ekkens, Z. Liu, Q. Liu, A. Foster, J. Whitmire, J. Pesce, A. H. Sharpe, J. F. Urban, and W. C. Gause (2002)
J. Immunol. 168, 6344-6351
 |  Abstract »  |  Full Text »  |  PDF »

Long-term therapy with recombinant human erythropoietin decreases percentage of CD152+ lymphocytes in primary glomerulonephritis haemodialysis patients.

P. Trzonkowski, J. Mysliwska, A. Debska-Slizien, E. Bryl, D. Rachon, A. Mysliwski, and B. Rutkowski (2002)
Nephrol. Dial. Transplant. 17, 1070-1080
 |  Abstract »  |  Full Text »  |  PDF »

Distinct Role of CD80 and CD86 in the Regulation of the Activation of B Cell and B Cell Lymphoma.

S. Suvas, V. Singh, S. Sahdev, H. Vohra, and J. N. Agrewala (2002)
J. Biol. Chem. 277, 7766-7775
 |  Abstract »  |  Full Text »  |  PDF »

Small Molecule Ligands Define a Binding Site on the Immune Regulatory Protein B7.1.

D. V. Erbe, S. Wang, Y. Xing, and J. F. Tobin (2002)
J. Biol. Chem. 277, 7363-7368
 |  Abstract »  |  Full Text »  |  PDF »

Calcineurin Inhibitor-Free CD28 Blockade-Based Protocol Protects Allogeneic Islets in Nonhuman Primates.

A. B. Adams, N. Shirasugi, M. M. Durham, E. Strobert, D. Anderson, P. Rees, S. Cowan, H. Xu, Y. Blinder, M. Cheung, et al. (2002)
Diabetes 51, 265-270
 |  Abstract »  |  Full Text »  |  PDF »

CD28 and CTLA4 Coordinately Regulate Airway Inflammatory Cell Recruitment and T-Helper Cell Differentiation after Inhaled Allergen.

J. S. Burr, S. L. Kimzey, D. R. Randolph, and J. M. Green (2001)
Am. J. Respir. Cell Mol. Biol. 24, 563-568
 |  Abstract »  |  Full Text »

CTLA-4-Fas ligand functions as a trans signal converter protein in bridging antigen-presenting cells and T cells.

J.-H. Huang and M. L. Tykocinski (2001)
Int. Immunol. 13, 529-539
 |  Abstract »  |  Full Text »  |  PDF »

FAS engagement drives apoptosis of enterocytes of coeliac patients.

L Maiuri, C Ciacci, V Raia, L Vacca, I Ricciardelli, F Raimondi, S Auricchio, S Quaratino, and M Londei (2001)
Gut 48, 418-424
 |  Abstract »  |  Full Text »  |  PDF »

Cutting Edge: Reversal of Murine Lupus Nephritis with CTLA4Ig and Cyclophosphamide.

D. I. Daikh and D. Wofsy (2001)
J. Immunol. 166, 2913-2916
 |  Abstract »  |  Full Text »  |  PDF »

Role of CD28/CD80-86 and CD40/CD154 Costimulatory Interactions in Host Defense to Primary Herpes Simplex Virus Infection.

K. H. Edelmann and C. B. Wilson (2001)
J. Virol. 75, 612-621
 |  Abstract »  |  Full Text »

In Situ Expression of Soluble B7-1 in the Context of Oncolytic Herpes Simplex Virus Induces Potent Antitumor Immunity.

T. Todo, R. L. Martuza, M. J. Dallman, and S. D. Rabkin (2001)
Cancer Res. 61, 153-161
 |  Abstract »  |  Full Text »

B7 Requirements for Primary and Secondary Protein- and Polysaccharide-Specific Ig Isotype Responses to Streptococcus pneumoniae.

Z.-Q. Wu, A. Q. Khan, Y. Shen, J. Schartman, R. Peach, A. Lees, J. J. Mond, W. C. Gause, and C. M. Snapper (2000)
J. Immunol. 165, 6840-6848
 |  Abstract »  |  Full Text »  |  PDF »

Enhanced antitumor immunity by fusion of CTLA-4 to a self tumor antigen.

T.-H. Huang, P.-Y. Wu, C.-N. Lee, H.-I Huang, S.-L. Hsieh, J. Kung, and M.-H. Tao (2000)
Blood 96, 3663-3670
 |  Abstract »  |  Full Text »  |  PDF »

CD28 Costimulatory Blockade Exacerbates Disease Severity and Accelerates Epitope Spreading in a Virus-Induced Autoimmune Disease.

K. L. Neville, M. C. Dal Canto, J. A. Bluestone, and S. D. Miller (2000)
J. Virol. 74, 8349-8357
 |  Abstract »  |  Full Text »

Tolerance to Cardiac Allografts Via Local and Systemic Mechanisms After Adenovirus-Mediated CTLA4Ig Expression.

C. Guillot, P. Mathieu, H. Coathalem, B. Le Mauff, M. G. Castro, L. Tesson, C. Usal, T. Laumonier, S. Brouard, J.-P. Soulillou, et al. (2000)
J. Immunol. 164, 5258-5268
 |  Abstract »  |  Full Text »  |  PDF »

CD134L Engagement Enhances Human B Cell Ig Production: CD154/CD40, CD70/CD27, and CD134/CD134L Interactions Coordinately Regulate T Cell-Dependent B Cell Responses.

S. Morimoto, Y. Kanno, Y. Tanaka, Y. Tokano, H. Hashimoto, S. Jacquot, C. Morimoto, S. F. Schlossman, H. Yagita, K. Okumura, et al. (2000)
J. Immunol. 164, 4097-4104
 |  Abstract »  |  Full Text »  |  PDF »

Coordinate Regulation of T Cell Activation by CD2 and CD28.

J. M. Green, V. Karpitskiy, S. L. Kimzey, and A. S. Shaw (2000)
J. Immunol. 164, 3591-3595
 |  Abstract »  |  Full Text »  |  PDF »

Blockade of CD28-B7, But Not CD40-CD154, Prevents Costimulation of Allogeneic Porcine and Xenogeneic Human Anti-Porcine T Cell Responses.

R. S. Lee, K. Yamada, K. L. Womer, E. P. Pillsbury, K. S. Allison, A. E. Marolewski, D. Geng, A. D. Thall, J. S. Arn, D. H. Sachs, et al. (2000)
J. Immunol. 164, 3434-3444
 |  Abstract »  |  Full Text »  |  PDF »

Prevention and treatment of factor VIII inhibitors in murine hemophilia A.

J. Qian, M. Collins, A. H. Sharpe, and L. W. Hoyer (2000)
Blood 95, 1324-1329
 |  Abstract »  |  Full Text »  |  PDF »

Naive CD8+ T Cells Do Not Require Costimulation for Proliferation and Differentiation into Cytotoxic Effector Cells.

B. Wang, R. Maile, R. Greenwood, E. J. Collins, and J. A. Frelinger (2000)
J. Immunol. 164, 1216-1222
 |  Abstract »  |  Full Text »  |  PDF »

A Critical Role for B7/CD28 Costimulation in Experimental Autoimmune Encephalomyelitis: A Comparative Study Using Costimulatory Molecule-Deficient Mice and Monoclonal Antibody Blockade.

A. M. Girvin, M. C. Dal Canto, L. Rhee, B. Salomon, A. Sharpe, J. A. Bluestone, and S. D. Miller (2000)
J. Immunol. 164, 136-143
 |  Abstract »  |  Full Text »  |  PDF »

CD28 Costimulation Mediates T Cell Expansion Via IL-2-Independent and IL-2-Dependent Regulation of Cell Cycle Progression.

L. J. Appleman, A. Berezovskaya, I. Grass, and V. A. Boussiotis (2000)
J. Immunol. 164, 144-151
 |  Abstract »  |  Full Text »  |  PDF »

Blockade of T Cell Costimulation by CTLA4-Ig Inhibits Lung Inflammation in Murine Hypersensitivity Pneumonitis.

E. Israel-Assayag, M. Fournier, and Y. Cormier (1999)
J. Immunol. 163, 6794-6799
 |  Abstract »  |  Full Text »  |  PDF »

Targeted toxins.

M W J d. Brok, G C de Gast, J H M Schellens, and J H Beijnen (1999)
Journal of Oncology Pharmacy Practice 5, 149-165
 |  Abstract »  |  PDF »

Cognate Stimulatory B-Cell-T-Cell Interactions Are Critical for T-Cell Help Recruited by Glycoconjugate Vaccines.

H.-K. Guttormsen, A. H. Sharpe, A. K. Chandraker, A. K. Brigtsen, M. H. Sayegh, and D. L. Kasper (1999)
Infect. Immun. 67, 6375-6384
 |  Abstract »  |  Full Text »  |  PDF »

Antigen-Driven Selection of TCR In Vivo: Related TCR {alpha}-Chains Pair with Diverse TCR {beta}-Chains.

J. A. Mikszta, L. J. McHeyzer-Williams, and M. G. McHeyzer-Williams (1999)
J. Immunol. 163, 5978-5988
 |  Abstract »  |  Full Text »  |  PDF »

4-1BB Ligand, a Member of the TNF Family, Is Important for the Generation of Antiviral CD8 T Cell Responses.

J. T. Tan, J. K. Whitmire, R. Ahmed, T. C. Pearson, and C. P. Larsen (1999)
J. Immunol. 163, 4859-4868
 |  Abstract »  |  Full Text »  |  PDF »

Stable Mixed Hematopoietic Chimerism in Dogs Given Donor Antigen, CTLA4Ig, and 100 cGy Total Body Irradiation Before and Pharmacologic Immunosuppression After Marrow Transplant.

R. Storb, C. Yu, J. M. Zaucha, H. J. Deeg, G. Georges, H.-P. Kiem, R. A. Nash, P. A. McSweeney, and J. L. Wagner (1999)
Blood 94, 2523-2529
 |  Abstract »  |  Full Text »  |  PDF »

The Future of Organ and Tissue Transplantation: Can T-Cell Costimulatory Pathway Modifiers Revolutionize the Prevention of Graft Rejection?.

D. M. Harlan and A. D. Kirk (1999)
JAMA 282, 1076-1082
 |  Abstract »  |  Full Text »  |  PDF »

Role of CD28 in the Generation of Effector and Memory Responses Required for Resistance to Toxoplasma gondii.

E. N. Villegas, M. M. Elloso, G. Reichmann, R. Peach, and C. A. Hunter (1999)
J. Immunol. 163, 3344-3353
 |  Abstract »  |  Full Text »  |  PDF »

The CD28/B7 Interaction Is Not Required for Resistance to Toxoplasma gondii in the Brain but Contributes to the Development of Immunopathology.

G. Reichmann, E. N. Villegas, L. Craig, R. Peach, and C. A. Hunter (1999)
J. Immunol. 163, 3354-3362
 |  Abstract »  |  Full Text »  |  PDF »

A Mathematical Model on Germinal Center Kinetics and Termination.

C. Kesmir and R. J. De Boer (1999)
J. Immunol. 163, 2463-2469
 |  Abstract »  |  Full Text »  |  PDF »

Resistance of Crohn's Disease T Cells to Multiple Apoptotic Signals Is Associated with a Bcl-2/Bax Mucosal Imbalance.

K. Ina, J. Itoh, K. Fukushima, K. Kusugami, T. Yamaguchi, K. Kyokane, A. Imada, D. G. Binion, A. Musso, G. A. West, et al. (1999)
J. Immunol. 163, 1081-1090
 |  Abstract »  |  Full Text »  |  PDF »

Differential Effects of a Stem Cell Factor-Immunoglobulin Fusion Protein on Malignant and Normal Hematopoietic Cells.

U. Erben, E. Thiel, and M. Notter (1999)
Cancer Res. 59, 2924-2930
 |  Abstract »  |  Full Text »  |  PDF »

Expression and Contribution of B7-1 (CD80) and B7-2 (CD86) in the Early Immune Response to Leishmania major Infection.

M. M. Elloso and P. Scott (1999)
J. Immunol. 162, 6708-6715
 |  Abstract »  |  Full Text »  |  PDF »

Arthritis: Is the Cure in Your Genes?*{{dagger}}.

J. H. HERNDON, P. D. ROBBINS, and C. H. EVANS (1999)
J. Bone Joint Surg. Am. 81, 152-7
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Blocking OX-40/OX-40 Ligand Interaction In Vitro and In Vivo Leads to Decreased T Cell Function and Amelioration of Experimental Allergic Encephalomyelitis.

A. D. Weinberg, K. W. Wegmann3, C. Funatake, and R. H. Whitham (1999)
J. Immunol. 162, 1818-1826
 |  Abstract »  |  Full Text »  |  PDF »

CD28-Deficient Mice Are Highly Resistant to Collagen-Induced Arthritis.

Y. Tada, K. Nagasawa, A. Ho, F. Morito, O. Ushiyama, N. Suzuki, H. Ohta, and T. W. Mak (1999)
J. Immunol. 162, 203-208
 |  Abstract »  |  Full Text »  |  PDF »

The Role of the CD40 Pathway in Alloantigen-Induced Hyporesponsiveness In Vivo.

M. Niimi, T. C. Pearson, C. P. Larsen, D. Z. Alexander, D. Hollenbaugh, A. Aruffo, P. S. Linsley, E. Thomas, K. Campbell, W. C. Fanslow, et al. (1998)
J. Immunol. 161, 5331-5337
 |  Abstract »  |  Full Text »  |  PDF »

Initiation of the Autologous Mixed Lymphocyte Reaction Requires the Expression of Costimulatory Molecules B7-1 and B7-2 on Human Peripheral Blood Dendritic Cells.

C. Scheinecker, K. P. Machold, O. Majdic, P. Hocker, W. Knapp, and J. S. Smolen (1998)
J. Immunol. 161, 3966-3973
 |  Abstract »  |  Full Text »  |  PDF »

Role of CD28 in Acute Graft-Versus-Host Disease.

X.-Z. Yu, P. J. Martin, and C. Anasetti (1998)
Blood 92, 2963-2970
 |  Abstract »  |  Full Text »  |  PDF »

Studies Using Antigen-Presenting Cells Lacking Expression of Both B7-1 (CD80) and B7-2 (CD86) Show Distinct Requirements for B7 Molecules During Priming Versus Restimulation of Th2 But Not Th1 Cytokine Production.

A. N. Schweitzer and A. H. Sharpe (1998)
J. Immunol. 161, 2762-2771
 |  Abstract »  |  Full Text »  |  PDF »

B7-1, But Not CD28, Is Crucial for the Maintenance of the CD4+ T Cell Responses in Human Leprosy.

K. Schlienger, K. Uyemura, D. Jullien, P. A. Sieling, T. H. Rea, P. S. Linsley3, and R. L. Modlin (1998)
J. Immunol. 161, 2407-2413
 |  Abstract »  |  Full Text »  |  PDF »

Impaired Alloantigen-Mediated T Cell Apoptosis and Failure To Induce Long-Term Allograft Survival in IL-2-Deficient Mice.

Z. Dai, B. T. Konieczny, F. K. Baddoura, and F. G. Lakkis (1998)
J. Immunol. 161, 1659-1663
 |  Abstract »  |  Full Text »  |  PDF »

Costimulatory Pathways in Lymphocyte Proliferation Induced by the Simian Immunodeficiency Virus SIVsmmPBj14.

L. Whetter, F. J. Novembre, M. Saucier, S. Gummuluru, and S. Dewhurst (1998)
J. Virol. 72, 6155-6158
 |  Abstract »  |  Full Text »  |  PDF »

Tissue-Specific Up-Regulation of B7-1 Expression and Function During the Course of Murine Relapsing Experimental Autoimmune Encephalomyelitis.

N. J. Karandikar, C. L. Vanderlugt, T. Eagar, L. Tan, J. A. Bluestone, and S. D. Miller (1998)
J. Immunol. 161, 192-199
 |  Abstract »  |  Full Text »  |  PDF »

Extrathymic T Cell Deletion and Allogeneic Stem Cell Engraftment Induced with Costimulatory Blockade Is Followed by Central T Cell Tolerance.

T. Wekerle, M. H. Sayegh, J. Hill, Y. Zhao, A. Chandraker, K. G. Swenson, G. Zhao, and M. Sykes (1998)
J. Exp. Med. 187, 2037-2044
 |  Abstract »  |  Full Text »  |  PDF »

Combinatorial Blockade of Calcineurin and CD28 Signaling Facilitates Primary and Secondary Therapeutic Gene Transfer by Adenovirus Vectors in Dystrophic (mdx) Mouse Muscles.

G.-H. Guibinga, H. Lochmuller, B. Massie, J. Nalbantoglu, G. Karpati, and B. J. Petrof (1998)
J. Virol. 72, 4601-4609
 |  Abstract »  |  Full Text »  |  PDF »

Thalidomide Costimulates Primary Human T Lymphocytes, Preferentially Inducing Proliferation, Cytokine Production, and Cytotoxic Responses in the CD8+ Subset.

P. A.J. Haslett, L. G. Corral, M. Albert, and G. Kaplan (1998)
J. Exp. Med. 187, 1885-1892
 |  Abstract »  |  Full Text »  |  PDF »

Blockade of Antibody-Induced Glomerulonephritis with Crry-Ig, a Soluble Murine Complement Inhibitor.

R. J. Quigg, Y. Kozono, D. Berthiaume, A. Lim, D. J. Salant, A. Weinfeld, P. Griffin, E. Kremmer, and V. M. Holers (1998)
J. Immunol. 160, 4553-4560
 |  Abstract »  |  Full Text »  |  PDF »

T:T Antigen Presentation by Activated Murine CD8+ T Cells Induces Anergy and Apoptosis.

J.-G. Chai, I. Bartok, D. Scott, J. Dyson, and R. Lechler (1998)
J. Immunol. 160, 3655-3665
 |  Abstract »  |  Full Text »  |  PDF »

Nucleic Acid Vaccine-Induced Immune Responses Require CD28 Costimulation and Are Regulated by CTLA4.

J. H. Horspool, P. J. Perrin, J. B. Woodcock, J. H. Cox, C. L. King, C. H. June, D. M. Harlan, D. C. St. Louis, and K. P. Lee (1998)
J. Immunol. 160, 2706-2714
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of Monoclonal Antibodies That Recognize Canine CD34.

P. A. McSweeney, K. A. Rouleau, P. M. Wallace, B. Bruno, R. G. Andrews, L. Krizanac-Bengez, B. M. Sandmaier, R. Storb, E. Wayner, and R. A. Nash (1998)
Blood 91, 1977-1986
 |  Abstract »  |  Full Text »  |  PDF »

IFN-{gamma} Is Critical for Long-Term Allograft Survival Induced by Blocking the CD28 and CD40 Ligand T Cell Costimulation Pathways.

B. T. Konieczny, Z. Dai, E. T. Elwood, S. Saleem, P. S. Linsley, F. K. Baddoura, C. P. Larsen, T. C. Pearson, and F. G. Lakkis (1998)
J. Immunol. 160, 2059-2064
 |  Abstract »  |  Full Text »  |  PDF »

IL-4 Enhances Long-Term Survival of CD28-Deficient T Cells.

R. M. Stack, C. B. Thompson, and F. W. Fitch (1998)
J. Immunol. 160, 2255-2262
 |  Abstract »  |  Full Text »  |  PDF »

Development of Murine Allergic Asthma Is Dependent Upon B7-2 Costimulation.

A. M. Keane-Myers, W. C. Gause, F. D. Finkelman, X.-d. Xhou, and M. Wills-Karp (1998)
J. Immunol. 160, 1036-1043
 |  Abstract »  |  Full Text »  |  PDF »

Role of Interleukin 12 and Costimulators in T Cell Anergy In Vivo.

L. V. Parijs, V. L. Perez, A. Biuckians, R. G. Maki, C. A. London, and A. K. Abbas (1997)
J. Exp. Med. 186, 1119-1128
 |  Abstract »  |  Full Text »  |  PDF »

Murine CTLA4-IgG Treatment Inhibits Airway Eosinophilia and Hyperresponsiveness and Attenuates IgE Upregulation in a Murine Model of Allergic Asthma.

A. J. M. Van Oosterhout, C. L. Hofstra, R. Shields, B. Chan, I. Van Ark, P. M. Jardieu, and F. P. Nijkamp (1997)
Am. J. Respir. Cell Mol. Biol. 17, 386-392
 |  Abstract »  |  Full Text »

Interferon gamma  (IFN-gamma ) Is Necessary for the Genesis of Acetylcholine Receptor-induced Clinical Experimental Autoimmune Myasthenia gravis in Mice.

B. Balasa, C. Deng, J. Lee, L. M. Bradley, D. K. Dalton, P. Christadoss, and N. Sarvetnick (1997)
J. Exp. Med. 186, 385-391
 |  Abstract »  |  Full Text »  |  PDF »

CD86 (B7-2) on Human B Cells. A FUNCTIONAL ROLE IN PROLIFERATION AND SELECTIVE DIFFERENTIATION INTO IgE- AND IgG4-PRODUCING CELLS.

P. Jeannin, Y. Delneste, S. Lecoanet-Henchoz, J.-F. Gauchat, J. Ellis, and J.-Y. Bonnefoy (1997)
J. Biol. Chem. 272, 15613-15619
 |  Abstract »  |  Full Text »  |  PDF »

Costimulation through B7-2 (CD86) Is Required for the Induction of a Lung Mucosal T Helper Cell 2 (TH2) Immune Response and Altered Airway Responsiveness.

S. Tsuyuki, J. Tsuyuki, K. Einsle, M. Kopf, and A. J. Coyle (1997)
J. Exp. Med. 185, 1671-1680
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CD80 Costimulation Is Essential for the Induction of Airway Eosinophilia.

N. Harris, R. Peach, J. Naemura, P. S. Linsley, G. Le Gros, and F. Ronchese (1997)
J. Exp. Med. 185, 177-182
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Costimulatory B7 Molecules in the Pathogenesis of Infectious and Autoimmune Diseases.

H. Reiser and M. J. Stadecker (1996)
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Long-term expression of human growth hormone (hGH) in mice containing allogeneic yolk sac cell derived neovascular implants expressing hGH.

Y Wei, J Li, and T. Wagner (1996)
Stem Cells 14, 232-238
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Treatment of murine lupus with CTLA4Ig.

B. Finck, P. Linsley, and D Wofsy (1994)
Science 265, 1225-1227
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Renal Transplantation.

M. Suthanthiran and T. B. Strom (1994)
N. Engl. J. Med. 331, 365-376
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Identification of an alternative CTLA-4 ligand costimulatory for T cell activation.

K. Hathcock, G Laszlo, H. Dickler, J Bradshaw, P Linsley, and R. Hodes (1993)
Science 262, 905-907
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Uncovering of functional alternative CTLA-4 counter-receptor in B7-deficient mice.

G. Freeman, F Borriello, R. Hodes, H Reiser, K. Hathcock, G Laszlo, A. McKnight, J Kim, L Du, D. Lombard, et al. (1993)
Science 262, 907-909
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Prevention of collagen-induced arthritis with an antibody to gp39, the ligand for CD40.

F. Durie, R. Fava, T. Foy, A Aruffo, J. Ledbetter, and R. Noelle (1993)
Science 261, 1328-1330
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Differential T cell costimulatory requirements in CD28-deficient mice.

A Shahinian, K Pfeffer, K. Lee, T. Kundig, K Kishihara, A Wakeham, K Kawai, P. Ohashi, C. Thompson, and T. Mak (1993)
Science 261, 609-612
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Identifying strategies for immune intervention.

A Lanzavecchia (1993)
Science 260, 937-944
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