Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Finnzymes

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 14 August 1992:
Vol. 257. no. 5072, pp. 919 - 927
DOI: 10.1126/science.1323877
Prev | Table of Contents | Next

Articles

Science, Vol 257, Issue 5072, 919-927
Copyright © 1992 by American Association for the Advancement of Science

articles

Crystal structures of two viral peptides in complex with murine MHC class I H-2Kb

DH Fremont, M Matsumura, EA Stura, PA Peterson, and IA Wilson

Department of Molecular Biology, Scripps Research Institute, La Jolla, CA 92037.

The x-ray structures of a murine MHC class I molecule (H-2Kb) were determined in complex with two different viral peptides, derived from the vesicular stomatitis virus nucleoprotein (52-59), VSV-8, and the Sendai virus nucleoprotein (324-332), SEV-9. The H-2Kb complexes were refined at 2.3 A for VSV-8 and 2.5 A for SEV-9. The structure of H-2Kb exhibits a high degree of similarity with human HLA class I, although the individual domains can have slightly altered dispositions. Both peptides bind in extended conformations with most of their surfaces buried in the H-2Kb binding groove. The nonamer peptide maintains the same amino- and carboxyl-terminal interactions as the octamer primarily by the insertion of a bulge in the center of an otherwise beta conformation. Most of the specific interactions are between side-chain atoms of H-2Kb and main-chain atoms of peptide. This binding scheme accounts in large part for the enormous diversity of peptide sequences that bind with high affinity to class I molecules. Small but significant conformational changes in H-2Kb are associated with peptide binding, and these synergistic movements may be an integral part of the T cell receptor recognition process.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Discovery of CD8+ T cell epitopes in Chlamydia trachomatis infection through use of caged class I MHC tetramers.
G. M. Grotenbreg, N. R. Roan, E. Guillen, R. Meijers, J.-h. Wang, G. W. Bell, M. N. Starnbach, and H. L. Ploegh (2008)
PNAS 105, 3831-3836
   Abstract »    Full Text »    PDF »
Cellular Expression and Crystal Structure of the Murine Cytomegalovirus Major Histocompatibility Complex Class I-like Glycoprotein, m153.
J. Mans, K. Natarajan, A. Balbo, P. Schuck, D. Eikel, S. Hess, H. Robinson, H. Simic, S. Jonjic, C. T. Tiemessen, et al. (2007)
J. Biol. Chem. 282, 35247-35258
   Abstract »    Full Text »    PDF »
Reduction of vector gene expression increases foreign antigen-specific CD8+ T-cell priming.
M. A. Fischer, D. C. Tscharke, K. B. Donohue, M. E. Truckenmiller, and C. C. Norbury (2007)
J. Gen. Virol. 88, 2378-2386
   Abstract »    Full Text »    PDF »
Influence of dominant HIV-1 epitopes on HLA-A3/peptide complex formation.
J. Racape, F. Connan, J. Hoebeke, J. Choppin, and J.-G. Guillet (2006)
PNAS 103, 18208-18213
   Abstract »    Full Text »    PDF »
A Single Amino Acid Difference within the {alpha}-2 Domain of Two Naturally Occurring Equine MHC Class I Molecules Alters the Recognition of Gag and Rev Epitopes by Equine Infectious Anemia Virus-Specific CTL.
R. H. Mealey, J.-H. Lee, S. R. Leib, M. H. Littke, and T. C. McGuire (2006)
J. Immunol. 177, 7377-7390
   Abstract »    Full Text »    PDF »
Structural Basis for Degenerate Recognition of Natural HIV Peptide Variants by Cytotoxic Lymphocytes.
E. Martinez-Hackert, N. Anikeeva, S. A. Kalams, B. D. Walker, W. A. Hendrickson, and Y. Sykulev (2006)
J. Biol. Chem. 281, 20205-20212
   Abstract »    Full Text »    PDF »
Structural Definition of the H-2Kd Peptide-binding Motif.
V. Mitaksov and D. H. Fremont (2006)
J. Biol. Chem. 281, 10618-10625
   Abstract »    Full Text »    PDF »
A Long N-terminal-extended Nested Set of Abundant and Antigenic Major Histocompatibility Complex Class I Natural Ligands from HIV Envelope Protein.
Y. Samino, D. Lopez, S. Guil, L. Saveanu, P. M. van Endert, and M. Del Val (2006)
J. Biol. Chem. 281, 6358-6365
   Abstract »    Full Text »    PDF »
Impact of Peptides on the Recognition of HLA Class I Molecules by Human HLA Antibodies.
A. Mulder, C. Eijsink, M. G. D. Kester, M. E. I. Franke, M. J. Kardol, M. H. M. Heemskerk, C. van Kooten, F. A. Verreck, J. W. Drijfhout, F. Koning, et al. (2005)
J. Immunol. 175, 5950-5957
   Abstract »    Full Text »    PDF »
The H-2Kk MHC Peptide-Binding Groove Anchors the Backbone of an Octameric Antigenic Peptide in an Unprecedented Mode.
C. Kellenberger, A. Roussel, and B. Malissen (2005)
J. Immunol. 175, 3819-3825
   Abstract »    Full Text »    PDF »
Design of enhanced agonists through the use of a new virtual screening method: Application to peptides that bind class I major histocompatibility complex (MHC) molecules.
S. Madurga, I. Belda, X. Llora, and E. Giralt (2005)
Protein Sci. 14, 2069-2079
   Abstract »    Full Text »    PDF »
A Structural Basis for CD8+ T Cell-dependent Recognition of Non-homologous Peptide Ligands: IMPLICATIONS FOR MOLECULAR MIMICRY IN AUTOREACTIVITY.
T. Sandalova, J. Michaelsson, R. A. Harris, J. Odeberg, G. Schneider, K. Karre, and A. Achour (2005)
J. Biol. Chem. 280, 27069-27075
   Abstract »    Full Text »    PDF »
High Resolution Structures of Highly Bulged Viral Epitopes Bound to Major Histocompatibility Complex Class I: IMPLICATIONS FOR T-CELL RECEPTOR ENGAGEMENT AND T-CELL IMMUNODOMINANCE.
F. E. Tynan, N. A. Borg, J. J. Miles, T. Beddoe, D. El-Hassen, S. L. Silins, W. J. M. van Zuylen, A. W. Purcell, L. Kjer-Nielsen, J. McCluskey, et al. (2005)
J. Biol. Chem. 280, 23900-23909
   Abstract »    Full Text »    PDF »
Crystal Structure of Dynein Light Chain TcTex-1.
J. C. Williams, H. Xie, and W. A. Hendrickson (2005)
J. Biol. Chem. 280, 21981-21986
   Abstract »    Full Text »    PDF »
Structural Basis for the Restoration of TCR Recognition of an MHC Allelic Variant by Peptide Secondary Anchor Substitution.
M. J. Miley, I. Messaoudi, B. M. Metzner, Y. Wu, J. Nikolich-Zugich, and D. H. Fremont (2004)
J. Exp. Med. 200, 1445-1454
   Abstract »    Full Text »    PDF »
The Myelin-Associated Oligodendrocytic Basic Protein Region MOBP15-36 Encompasses the Immunodominant Major Encephalitogenic Epitope(s) for SJL/J Mice and Predicted Epitope(s) for Multiple Sclerosis-Associated HLA-DRB1*1501.
N. K. de Rosbo, J. F. Kaye, M. Eisenstein, I. Mendel, R. Hoeftberger, H. Lassmann, R. Milo, and A. Ben-Nun (2004)
J. Immunol. 173, 1426-1435
   Abstract »    Full Text »    PDF »
Structures of HLA-A*1101 Complexed with Immunodominant Nonamer and Decamer HIV-1 Epitopes Clearly Reveal the Presence of a Middle, Secondary Anchor Residue.
L. Li and M. Bouvier (2004)
J. Immunol. 172, 6175-6184
   Abstract »    Full Text »    PDF »
Designer Glycopeptides for Cytotoxic T Cell-based Elimination of Carcinomas.
Y. Xu, S. J. Gendler, and A. Franco (2004)
J. Exp. Med. 199, 707-716
   Abstract »    Full Text »    PDF »
A Peptide That Antagonizes TCR-Mediated Reactions with Both Syngeneic and Allogeneic Agonists: Functional and Structural Aspects.
M. G. Rudolph, L. Q. Shen, S. A. Lamontagne, J. G. Luz, J. R. Delaney, Q. Ge, B. K. Cho, D. Palliser, C. A. McKinley, J. Chen, et al. (2004)
J. Immunol. 172, 2994-3002
   Abstract »    Full Text »    PDF »
The Impact of Self-Tolerance on the Polyclonal CD8+ T Cell Repertoire.
H. W. H. G. Kessels, K. E. de Visser, F. H. Tirion, M. Coccoris, A. M. Kruisbeek, and T. N. M. Schumacher (2004)
J. Immunol. 172, 2324-2331
   Abstract »    Full Text »    PDF »
Presentation of a Self-peptide in Two Distinct Conformations by a Disease-associated HLA-B27 Subtype.
K. W. Wucherpfennig (2004)
J. Exp. Med. 199, 151-154
   Full Text »    PDF »
Thermodynamic and Structural Analysis of Peptide- and Allele-dependent Properties of Two HLA-B27 Subtypes Exhibiting Differential Disease Association.
R. C. Hillig, M. Hulsmeyer, W. Saenger, K. Welfle, R. Misselwitz, H. Welfle, C. Kozerski, A. Volz, B. Uchanska-Ziegler, and A. Ziegler (2004)
J. Biol. Chem. 279, 652-663
   Abstract »    Full Text »    PDF »
A glycopeptide in complex with MHC class I uses the GalNAc residue as an anchor.
V. Apostolopoulos, E. Yuriev, P. A. Ramsland, J. Halton, C. Osinski, W. Li, M. Plebanski, H. Paulsen, and I. F. C. McKenzie (2003)
PNAS 100, 15029-15034
   Abstract »    Full Text »    PDF »
Mimicry of Native Peptide Antigens by the Corresponding Retro-Inverso Analogs Is Dependent on Their Intrinsic Structure and Interaction Propensities.
D. T. Nair, K. J. Kaur, K. Singh, P. Mukherjee, D. Rajagopal, A. George, V. Bal, S. Rath, K. V. S. Rao, and D. M. Salunke (2003)
J. Immunol. 170, 1362-1373
   Abstract »    Full Text »    PDF »
Competition Between MHC Class I Alleles for Cell Surface Expression Alters CTL Responses to Influenza A Virus.
S. Tourdot and K. G. Gould (2002)
J. Immunol. 169, 5615-5621
   Abstract »    Full Text »    PDF »
The Structure of HLA-B8 Complexed to an Immunodominant Viral Determinant: Peptide-Induced Conformational Changes and a Mode of MHC Class I Dimerization.
L. Kjer-Nielsen, C. S. Clements, A. G. Brooks, A. W. Purcell, M. R. Fontes, J. McCluskey, and J. Rossjohn (2002)
J. Immunol. 169, 5153-5160
   Abstract »    Full Text »    PDF »
Polymorphism at Position 97 in MHC Class I Molecules Affects Peptide Specificity, Cell Surface Stability, and Affinity for {beta}2-Microglobulin.
R. A. Smith, N. B. Myers, M. Robinson, T. H. Hansen, and D. R. Lee (2002)
J. Immunol. 169, 3105-3111
   Abstract »    Full Text »    PDF »
Peptidic Termini Play a Significant Role in TCR Recognition.
B. Wang, A. Sharma, R. Maile, M. Saad, E. J. Collins, and J. A. Frelinger (2002)
J. Immunol. 169, 3137-3145
   Abstract »    Full Text »    PDF »
T Cell Recognition of an Engineered MHC Class I Molecule: Implications for Peptide-Independent Alloreactivity.
V. Jankovic, K. Remus, A. Molano, and J. Nikolich-Zugich (2002)
J. Immunol. 169, 1887-1892
   Abstract »    Full Text »    PDF »
Conserved water molecules in MHC class-I molecules and their putative structural and functional roles.
K. Ogata and S. J. Wodak (2002)
Protein Eng. Des. Sel. 15, 697-705
   Abstract »    Full Text »    PDF »
Alternate interactions define the binding of peptides to the MHC molecule IAb.
X. Liu, S. Dai, F. Crawford, R. Fruge, P. Marrack, and J. Kappler (2002)
PNAS 99, 8820-8825
   Abstract »    Full Text »    PDF »
Analysis of structure and function relationships of an autoantigenic peptide of insulin bound to H-2Kd that stimulates CD8 T cells in insulin-dependent diabetes mellitus.
F. S. Wong, A. K. Moustakas, L. Wen, G. K. Papadopoulos, and C. A. Janeway Jr. (2002)
PNAS 99, 5551-5556
   Abstract »    Full Text »    PDF »
Structure of a Complex of the Human {alpha}/{beta} T Cell Receptor (TCR) HA1.7, Influenza Hemagglutinin Peptide, and Major Histocompatibility Complex Class II Molecule, HLA-DR4 (DRA0101 and DRB10401): Insight into TCR Cross-Restriction and Alloreactivity.
J. Hennecke and D. C. Wiley (2002)
J. Exp. Med. 195, 571-581
   Abstract »    Full Text »    PDF »
Virus-specific CTL responses induced by an H-2Kd-restricted, motif-negative 15-mer peptide from the fusion protein of respiratory syncytial virus.
S. Jiang, N. J. Borthwick, P. Morrison, G. F. Gao, and M. W. Steward (2002)
J. Gen. Virol. 83, 429-438
   Abstract »    Full Text »    PDF »
C-Terminal Anchoring of a Peptide to Class II MHC Via the P10 Residue Is Compatible with a Peptide Bulge.
M. Yassai, A. Afsari, J. Garlie, and J. Gorski (2002)
J. Immunol. 168, 1281-1285
   Abstract »    Full Text »    PDF »
NK Cell Inhibitory Receptor Ly-49C Residues Involved in MHC Class I Binding.
J. Sundback, A. Achour, J. Michaelsson, H. Lindstrom, and K. Karre (2002)
J. Immunol. 168, 793-800
   Abstract »    Full Text »    PDF »
How H13 Histocompatibility Peptides Differing by a Single Methyl Group and Lacking Conventional MHC Binding Anchor Motifs Determine Self-Nonself Discrimination.
D. A. Ostrov, M. M. Roden, W. Shi, E. Palmieri, G. J. Christianson, L. Mendoza, G. Villaflor, D. Tilley, N. Shastri, H. Grey, et al. (2002)
J. Immunol. 168, 283-289
   Abstract »    Full Text »    PDF »
Peptide Length Variants p2Ca and QL9 Present Distinct Conformations to Ld-Specific T Cells.
T. M. C. Hornell, S. M. Martin, N. B. Myers, and J. M. Connolly (2001)
J. Immunol. 167, 4207-4214
   Abstract »    Full Text »    PDF »
Hapten Addition to an MHC Class I-Binding Peptide Causes Substantial Adjustments of the TCR Structure of the Responding CD8+ T Cells.
S. Honda, W. Zhang, A. M. Kalergis, T. P. DiLorenzo, F. Wang, and S. G. Nathenson (2001)
J. Immunol. 167, 4276-4285
   Abstract »    Full Text »    PDF »
Immunobiological Analysis of TCR Single-Chain Transgenic Mice Reveals New Possibilities for Interaction between CDR3{alpha} and an Antigenic Peptide Bound to MHC Class I.
W. Zhang, S. Honda, F. Wang, T. P. DiLorenzo, A. M. Kalergis, D. A. Ostrov, and S. G. Nathenson (2001)
J. Immunol. 167, 4396-4404
   Abstract »    Full Text »    PDF »
Functional Evidence That Conserved TCR CDR{{alpha}}3 Loop Docking Governs the Cross-Recognition of Closely Related Peptide:Class I Complexes.
I. Messaoudi, J. LeMaoult, B. M. Metzner, M. J. Miley, D. H. Fremont, and J. Nikolich-Zugich (2001)
J. Immunol. 167, 836-843
   Abstract »    Full Text »    PDF »
T Cell Responses to HLA-A*0201-Restricted Peptides Derived from Human {{alpha}} Fetoprotein.
L. H. Butterfield, W. S. Meng, A. Koh, C. M. Vollmer, A. Ribas, V. B. Dissette, K. Faull, J. A. Glaspy, W. H. McBride, and J. S. Economou (2001)
J. Immunol. 166, 5300-5308
   Abstract »    Full Text »    PDF »
Antiviral Cytotoxic T Cells Cross-Reactively Recognize Disparate Peptide Determinants from Related Viruses but Ignore More Similar Self- and Foreign Determinants.
M. Regner, M. Lobigs, R. V. Blanden, P. Milburn, and A. Mullbacher (2001)
J. Immunol. 166, 3820-3828
   Abstract »    Full Text »    PDF »
Class I MHC Expression in the Yellow Baboon.
D. A. Sidebottom, R. Kennedy, and W. H. Hildebrand (2001)
J. Immunol. 166, 3983-3993
   Abstract »    Full Text »    PDF »
A Structural Difference Limited to One Residue of the Antigenic Peptide Can Profoundly Alter the Biological Outcome of the TCR-Peptide/MHC Class I Interaction.
C. T. Thomson, A. M. Kalergis, J. C. Sacchettini, and S. G. Nathenson (2001)
J. Immunol. 166, 3994-3997
   Abstract »    Full Text »    PDF »
The A' and F' Pockets of Human CD1b Are Both Required for Optimal Presentation of Lipid Antigens to T Cells.
K. R. Niazi, M. W. Chiu, R. M. Mendoza, M. Degano, S. Khurana, D. B. Moody, A. Melian, I. A. Wilson, M. Kronenberg, S. A. Porcelli, et al. (2001)
J. Immunol. 166, 2562-2570
   Abstract »    Full Text »    PDF »
Supra-Agonist Peptides Enhance the Reactivation of Memory CTL Responses.
F. Micheletti, A. Canella, S. Vertuani, M. Marastoni, L. Tosi, S. Volinia, S. Traniello, and R. Gavioli (2000)
J. Immunol. 165, 4264-4271
   Abstract »    Full Text »    PDF »
The Alloreactive and Self-Restricted CD4+ T Cell Response Directed Against a Single MHC Class II/Peptide Combination.
J.-P. Kovalik, N. Singh, S. K. Mendiratta, W. D. Martin, L. Ignatowicz, and L. Van Kaer (2000)
J. Immunol. 165, 1285-1293
   Abstract »    Full Text »    PDF »
Direct selection of a human antibody fragment directed against the tumor T-cell epitope HLA-A1-MAGE-A1 from a nonimmunized phage-Fab library.
P. Chames, S. E. Hufton, P. G. Coulie, B. Uchanska-Ziegler, and H. R. Hoogenboom (2000)
PNAS 97, 7969-7974
   Abstract »    Full Text »    PDF »
Water dynamics at the binding interface of four different HLA-A2-peptide complexes.
W. S. Meng, H. von Grafenstein, and I. S. Haworth (2000)
Int. Immunol. 12, 949-957
   Abstract »    Full Text »    PDF »
T Cell Tolerance Based on Avidity Thresholds Rather Than Complete Deletion Allows Maintenance of Maximal Repertoire Diversity.
J. K. Sandberg, L. Franksson, J. Sundback, J. Michaelsson, M. Petersson, A. Achour, R. P. A. Wallin, N. E. Sherman, T. Bergman, H. Jornvall, et al. (2000)
J. Immunol. 165, 25-33
   Abstract »    Full Text »    PDF »
Altered Peptide Ligand-Mediated TCR Antagonism Can Be Modulated by a Change in a Single Amino Acid Residue Within the CDR3{beta} of an MHC Class I-Restricted TCR.
A. M. Kalergis and S. G. Nathenson (2000)
J. Immunol. 165, 280-285
   Abstract »    Full Text »    PDF »
The Structure and Stability of an HLA-A*0201/Octameric Tax Peptide Complex with an Empty Conserved Peptide-N-Terminal Binding Site.
A. R. Khan, B. M. Baker, P. Ghosh, W. E. Biddison, and D. C. Wiley (2000)
J. Immunol. 164, 6398-6405
   Abstract »    Full Text »    PDF »
An N-acetylated Natural Ligand of Human Histocompatibility Leukocyte Antigen (HLA)-B39: Classical Major Histocompatibility Complex Class I Proteins Bind Peptides with a Blocked NH2 Terminus In Vivo.
J. Yague, I. Alvarez, D. Rognan, M. Ramos, J. Vazquez, and J. A. L. de Castro (2000)
J. Exp. Med. 191, 2083-2092
   Abstract »    Full Text »    PDF »
Positive Selection Is Limited by Available Peptide-Dependent MHC Conformations.
H. E. Stefanski, S. C. Jameson, and K. A. Hogquist (2000)
J. Immunol. 164, 3519-3526
   Abstract »    Full Text »    PDF »
Minimal peptide length requirements for CD4+ T cell clones--implications for molecular mimicry and T cell survival.
B. Hemmer, T. Kondo, B. Gran, C. Pinilla, I. Cortese, J. Pascal, A. Tzou, H. F. McFarland, R. Houghten, and R. Martin (2000)
Int. Immunol. 12, 375-383
   Abstract »    Full Text »    PDF »
MHC Polymorphism Can Enrich the T Cell Repertoire of the Species by Shifts in Intrathymic Selection.
R. Dyall, I. Messaoudi, and S. Janetzki (2000)
J. Immunol. 164, 1695-1698
   Abstract »    Full Text »    PDF »
Cytotoxic T Lymphocyte Epitopes of HIV-1 Nef: Generation of Multiple Definitive Major Histocompatibility Complex Class I Ligands by Proteasomes.
M. Lucchiari-Hartz, P. M. van Endert, G. Lauvau, R. Maier, A. Meyerhans, D. Mann, K. Eichmann, and G. Niedermann (2000)
J. Exp. Med. 191, 239-252
   Abstract »    Full Text »    PDF »
Crystal Structure of a T Cell Receptor Ligand T22: A Truncated MHC-Like Fold.
C. Wingren, M. P. Crowley, I. S. A. M. Degano, Y. Chien, and I. A. Wilson (2000)
Science 287, 310-314
   Abstract »    Full Text »
The Crystal Structure of a T Cell Receptor in Complex with Peptide and MHC Class II.
E. L. Reinherz, K. Tan, L. Tang, P. Kern, J. Liu, Y. Xiong, R. E. Hussey, A. Smolyar, B. Hare, R. Zhang, et al. (1999)
Science 286, 1913-1921
   Abstract »    Full Text »
Definition and transfer of a serological epitope specific for peptide-empty forms of MHC class I.
Y. Y. L. Yu, N. B. Myers, C. M. Hilbert, M. R. Harris, G. K. Balendiran, and T. H. Hansen (1999)
Int. Immunol. 11, 1897-1906
   Abstract »    Full Text »    PDF »
Ly-49CB6 NK Inhibitory Receptor Recognizes Peptide-Receptive H-2Kb 1.
R.-C. Su, S. K.-P. Kung, E. T. Silver, S. Lemieux, K. P. Kane, and R. G. Miller (1999)
J. Immunol. 163, 5319-5330
   Abstract »    Full Text »    PDF »
Structure of Human Histocompatibility Leukocyte Antigen (HLA)-Cw4, a Ligand for the KIR2D Natural Killer Cell Inhibitory Receptor.
Q. R. Fan and D. C. Wiley (1999)
J. Exp. Med. 190, 113-124
   Abstract »    Full Text »    PDF »
Diverse Fine Specificity and Receptor Repertoire of T Cells Reactive to the Major VP1 Epitope (VP1230-250) of Theiler's Virus: V{beta} Restriction Correlates with T Cell Recognition of the C-Terminal Residue.
B. S. Kim, Y. Y. Bahk, H.-K. Kang, R. L. Yauch, J.-A. Kang, M.-J. Park, and N. M. Ponzio (1999)
J. Immunol. 162, 7049-7057
   Abstract »    Full Text »    PDF »
Single Amino Acid Replacements in an Antigenic Peptide Are Sufficient to Alter the TCR V{beta} Repertoire of the Responding CD8+ Cytotoxic Lymphocyte Population.
A. M. Kalergis, T. Ono, F. Wang, T. P. DiLorenzo, S. Honda, and S. G. Nathenson (1999)
J. Immunol. 162, 7263-7270
   Abstract »    Full Text »    PDF »
A novel recognition motif of human NKT antigen receptor for a glycolipid ligand.
T. Kawano, Y. Tanaka, E. Shimizu, Y. Kaneko, N. Kamata, H. Sato, H. Osada, S. Sekiya, T. Nakayama, and M. Taniguchi (1999)
Int. Immunol. 11, 881-887
   Abstract »    Full Text »    PDF »
Recognition of an MHC Class I-Restricted Antigenic Peptide Can Be Modulated by para-Substitution of Its Buried Tyrosine Residues in a TCR-Specific Manner.
N. G. Saito, H.-C. Chang, and Y. Paterson (1999)
J. Immunol. 162, 5998-6008
   Abstract »    Full Text »    PDF »
Dramatic Influence of V{beta} Gene Polymorphism on an Antigen-Specific CD8+ T Cell Response In Vivo.
H. Bour, O. Michielin, P. Bousso, J.-C. Cerottini, and H. R. MacDonald (1999)
J. Immunol. 162, 4647-4656
   Abstract »    Full Text »    PDF »
Role of Peptide Backbone in T Cell Recognition.
S. Calbo, G. Guichard, P. Bousso, S. Muller, P. Kourilsky, J.-P. Briand, and J.-P. Abastado (1999)
J. Immunol. 162, 4657-4662
   Abstract »    Full Text »    PDF »
Specific Proteolytic Cleavages Limit the Diversity of the Pool of Peptides Available to MHC Class I Molecules in Living Cells.
T. Serwold and N. Shastri (1999)
J. Immunol. 162, 4712-4719
   Abstract »    Full Text »    PDF »
Fine Specificity and MHC Restriction of Trinitrophenyl- Specific CTL.
A. Franco, T. Yokoyama, D. Huynh, C. Thomson, S. G. Nathenson, and H. M. Grey (1999)
J. Immunol. 162, 3388-3394
   Abstract »    Full Text »    PDF »
Peptide dependency of alloreactive CD4+ T cell responses.
S. K. Mendiratta, J.-P. Kovalik, S. Hong, N. Singh, W. D. Martin, and L. Van Kaer (1999)
Int. Immunol. 11, 351-360
   Abstract »    Full Text »    PDF »
The Orientation and Nature of the Interaction Between Beef Insulin-Specific TCRs and the Insulin/Class II MHC Complex.
J. E. Wither and B. Vukusic (1999)
J. Immunol. 162, 2113-2122
   Abstract »    Full Text »    PDF »
Structural Evidence of  T Cell Xeno-reactivity in the Absence of Molecular Mimicry.
R. Zhao, D. J. Loftus, E. Appella, and E. J. Collins (1999)
J. Exp. Med. 189, 359-370
   Abstract »    Full Text »    PDF »
A Single Specific Amino Acid Residue in Peptide Antigens Is Sufficient to Activate Memory CTL: Potential Role of Cross-Reactive Peptides in Memory T Cell Maintenance.
E. Reali, R. Guerrini, M. Marastoni, R. Tomatis, M. Grazia Masucci, S. Traniello, and R. Gavioli (1999)
J. Immunol. 162, 106-113
   Abstract »    Full Text »    PDF »
Alterations in TCR-MHC Contacts Subsequent to Cross-Recognition of Class I MHC and Singly Substituted Peptide Variants.
T. Ono, T. P. DiLorenzo, F. Wang, A. M. Kalergis, and S. G. Nathenson (1998)
J. Immunol. 161, 5454-5463
   Abstract »    Full Text »    PDF »
The Same Natural Ligand Is Involved in Allorecognition of Multiple HLA-B27 Subtypes by a Single T Cell Clone: Role of Peptide and the MHC Molecule in Alloreactivity.
A. Paradela, M. Garcia-Peydro, J. Vazquez, D. Rognan, and J. A. Lopez de Castro (1998)
J. Immunol. 161, 5481-5490
   Abstract »    Full Text »    PDF »
A Molecular Basis for How a Single TCR Interfaces Multiple Ligands.
A. Boesteanu, M. Brehm, L. M. Mylin, G. J. Christianson, S. S. Tevethia, D. C. Roopenian, and S. Joyce (1998)
J. Immunol. 161, 4719-4727
   Abstract »    Full Text »    PDF »
The Importance of Pairwise Interactions Between Peptide Residues in the Delineation of TCR Specificity.
G. R. Leggatt, A. Hosmalin, C. D. Pendleton, A. Kumar, S. Hoffman, and J. A. Berzofsky (1998)
J. Immunol. 161, 4728-4735
   Abstract »    Full Text »    PDF »
New Synthetic Non-peptide Ligands for Classical Major Histocompatibility Complex Class I Molecules.
A. Bianco, C. Brock, C. Zabel, T. Walk, P. Walden, and G. Jung (1998)
J. Biol. Chem. 273, 28759-28765
   Abstract »    Full Text »    PDF »
Large Protein Fragments as Substrates for Endocytic Antigen Capture by MHC Class II Molecules.
F. Castellino, F. Zappacosta, J. E. Coligan, and R. N. Germain (1998)
J. Immunol. 161, 4048-4057
   Abstract »    Full Text »    PDF »
The MHC Class I-Restricted Immune Response to HIV-gag in BALB/c Mice Selects a Single Epitope That Does Not Have a Predictable MHC-Binding Motif and Binds to Kd Through Interactions Between a Glutamine at P3 and Pocket D.
M. Mata, P. J. Travers, Q. Liu, F. R. Frankel, and Y. Paterson (1998)
J. Immunol. 161, 2985-2993
   Abstract »    Full Text »    PDF »
Differential thymic selection outcomes stimulated by focal structural alteration in peptide/major histocompatibility complex ligands.
Y. Ghendler, M.-k. Teng, J.-h. Liu, T. Witte, J. Liu, K. S. Kim, P. Kern, H.-C. Chang, J.-h. Wang, and E. L. Reinherz (1998)
PNAS 95, 10061-10066
   Abstract »    Full Text »    PDF »
Subtle conformational changes induced in major histocompatibility complex class II molecules by binding peptides.
A. V. Chervonsky, R. M. Medzhitov, L. K. Denzin, A. K. Barlow, A. Yu. Rudensky, and C. A. Janeway Jr. (1998)
PNAS 95, 10094-10099
   Abstract »    Full Text »    PDF »
NK Cells Can Recognize Different Forms of Class I MHC.
R.-C. Su, S. K. P. Kung, J. Gariepy, B. H. Barber, and R. G. Miller (1998)
J. Immunol. 161, 755-766
   Abstract »    Full Text »    PDF »
Anti-MUC1 Antibodies React Directly with MUC1 Peptides Presented by Class I H2 and HLA Molecules.
V. Apostolopoulos, G. Chelvanayagam, P.-X. Xing, and I. F. C. McKenzie (1998)
J. Immunol. 161, 767-775
   Abstract »    Full Text »    PDF »