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Science 6 November 1992: Vol. 258. no. 5084, pp. 955 - 964 DOI: 10.1126/science.1439807
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Articles
Science, Vol 258, Issue 5084, 955-964
Copyright © 1992 by American Association for the Advancement of Science
Cytoskeleton--plasma membrane interactions
EJ Luna
and
AL Hitt
Cell Biology Group, Worcester Foundation for Experimental Biology, Shrewsbury, MA 01545.
Proteins at the boundary between the cytoskeleton and the plasma membrane control cell shape, delimit specialized membrane domains, and stabilize attachments to other cells and to the substrate. These proteins also regulate cell locomotion and cytoplasmic responses to growth factors and other external stimuli. This diversity of cellular functions is matched by the large number of biochemical mechanisms that mediate the connections between membrane proteins and the underlying cytoskeleton, the so-called membrane skeleton. General organizational themes are beginning to emerge from examination of this biochemical diversity.
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