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Science 27 November 1992:
Vol. 258. no. 5087, pp. 1491 - 1494
DOI: 10.1126/science.1279812
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Articles

Science, Vol 258, Issue 5087, 1491-1494
Copyright © 1992 by American Association for the Advancement of Science

articles

Amelioration of autoimmune encephalomyelitis by myelin basic protein synthetic peptide-induced anergy

A Gaur, B Wiers, A Liu, J Rothbard, and CG Fathman

Stanford University School of Medicine, Division of Immunology and Rheumatology, CA 94305.

Experimental autoimmune encephalomyelitis (EAE), a demyelinating disease of the central nervous system that can be induced in susceptible strains of mice by immunization with myelin basic protein (MBP) or its immunodominant T cell determinants, serves as a model of human multiple sclerosis. Tolerance to MBP in adult mice was induced by intraperitoneal injection of synthetic peptides of immunodominant determinants of MBP and prevented MBP-induced EAE. Furthermore, tolerance-inducing regimens of peptides administered to mice after the disease had begun (10 days after induction with MBP) blocked the progression and decreased the severity of EAE. Peptide-induced tolerance resulted from the induction of anergy in proliferative, antigen-specific T cells.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)