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Science 11 December 1992:
Vol. 258. no. 5089, pp. 1792 - 1795
DOI: 10.1126/science.1299224
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Articles
Science, Vol 258, Issue 5089, 1792-1795
Copyright © 1992 by American Association for the Advancement of Science
Ablation of transplanted HTLV-I Tax-transformed tumors in mice by antisense inhibition of NF-kappa B
I Kitajima,
T Shinohara,
J Bilakovics,
DA Brown,
X Xu,
and
M Nerenberg
Department of Neuropharmacology, Scripps Research Institute, La Jolla, CA 92037.
Mice transgenic for the human T cell leukemia virus (HTLV-I) Tax gene develop fibroblastic tumors that express NF-kappa B-inducible early genes. In vitro inhibition of NF-kappa B expression by antisense oligodeoxynucleotides (ODNs) inhibited growth of these culture-adapted Tax-transformed fibroblasts as well as an HTLV-I-transformed human lymphocyte line. In contrast, antisense inhibition of Tax itself had no apparent effect on cell growth. Mice treated with antisense to NF-kappa B ODNs showed rapid regression of transplanted fibrosarcomas. This suggests that NF-kappa B expression may be necessary for the maintenance of the malignant phenotype and provides a therapeutic approach for HTLV-I-associated disease.
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